Genome Property Definition Page
| Accession | GenProp0860 | |
| Name | tryptophan tryptophylquinone modification of methylamine dehydrogenase | |
| Type | SYSTEM | |
| Description | The maturation enzyme MauG completes the modification and cross-linking of a pair of Trp residues into the novel cofactor tryptophan tryptophylquinone, or TTQ, in the light chain (MauA) of methylamine dehydrogenase. While some analogous enzyme cofactors are produced autocatalytically from amino acids in the precursor polypeptide, TTQ is produced with aid of the maturation enzyme MauG. MauG is a di-heme enzyme with peroxidase activity, similar to di-heme cytochrome c peroxidases of other biological systems. Interestingly, the pair of modified Trp residues is conserved in MauA homologs in species that have no MauG homolog in the vicinity, suggesting no modification, autocatalytic modification, or a different modification enzyme. | |
| Parent Property | GenProp0075: protein modification, prosthetic groups and cofactors GenProp0184: cofactor biosynthesis | |
| Literature References |
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Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| methylamine dehydrogenase, light chain | MauA | YES | TIGR02659 (HMM): methylamine dehydrogenase (amicyanin) light chain | |
| methylamine dehydrogenase heavy chain | MauB | YES | TIGR02658 (HMM): methylamine dehydrogenase (amicyanin) heavy chain | |
| methylamine dehydrogenase accessory protein MauD | MauD | YES | TIGR02661 (HMM): methylamine dehydrogenase accessory protein MauD | |
| TTQ maturation di-heme protein MauG | MauG | YES | TIGR03791 (HMM): tryptophan tryptophylquinone biosynthesis enzyme MauG |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0075 | protein modification, prosthetic groups and cofactors |
| GenProp0184 | cofactor biosynthesis |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0002 | coenzyme F420 utilization |
| GenProp0016 | selenocysteine system |
| GenProp0061 | lipoprotein system lgt/lsp/lnt |
| GenProp0127 | Tat (Sec-independent) protein export |
| GenProp0284 | cobalamin-utilizing enzymes |
| GenProp0295 | prokaryotic N-terminal cleavage/methylation, type IV pilin-like |
| GenProp0726 | selenium-dependent molybdenum hydroxylase system |
| GenProp0745 | lipoyl-protein attachment |
| GenProp0918 | anaerobic sulfatase/maturase system |
| GenProp0923 | mycothiol system |
| GenProp0933 | bacillithiol utilization |
| GenProp0938 | glycine radical enzyme system, YjjI/YjjW pair |
| GenProp0943 | pyruvate formate-lyase system |
| GenProp0001 | chorismate biosynthesis via shikimate |
| GenProp0030 | glutathione biosynthesis |
| GenProp0036 | biotin biosynthesis |
| GenProp0038 | tetrahydrofolate biosynthesis from GTP and PABA |
| GenProp0057 | NAD(P) biosynthesis from L-aspartate and DHAP |
| GenProp0112 | riboflavin, FAD and FMN from GTP and ribulose-5-P |
| GenProp0124 | pantothenate biosynthesis from aspartate and 2-oxoisovalerate |
| GenProp0136 | ubiquinone biosynthesis from chorismate, aerobic |
| GenProp0140 | iron-sulfur cluster assembly systems |
| GenProp0170 | coenzyme PQQ biosynthesis |
| GenProp0171 | coenzyme A biosynthesis from pantothenate |
| GenProp0194 | siroheme biosynthesis from uroporphrinogen-III |
| GenProp0220 | uroporhyrinogen III biosynthesis from 5-aminolevulinate |
| GenProp0221 | protoporphyrin IX biosynthesis from uroporphyrinogen III |
| GenProp0222 | protoheme from protoporphyrin IX |
| GenProp0250 | thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly |
| GenProp0255 | 5-aminolevulinate biosynthesis |
| GenProp0261 | thiamin pyrophosphate (TPP) de novo biosynthesis |
| GenProp0274 | coenzyme B12 biosynthesis - overview |
| GenProp0300 | photosynthetic cofactor biosynthesis |
| GenProp0466 | molybdopterin biosynthesis |
| GenProp0752 | ergothioneine biosynthesis |
| GenProp0753 | mycothiol biosynthesis |
| GenProp0759 | para-aminobenzoic acid (PABA) biosynthesis from chorismate |
| GenProp0791 | coenzyme F420 biosynthesis |
| GenProp0792 | 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis |
| GenProp0836 | menaquinone biosynthesis |
| GenProp0862 | pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway |
| GenProp0863 | pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway |
| GenProp0891 | coenzyme M biosynthesis |
| GenProp0917 | mycofactocin system |
| GenProp0927 | bacillithiol biosynthesis |
| GenProp1064 | ovothiol biosynthesis |
| GenProp1096 | coenzyme B biosynthesis |