Genome Property Definition Page

Nametryptophan tryptophylquinone modification of methylamine dehydrogenase
DescriptionThe maturation enzyme MauG completes the modification and cross-linking of a pair of Trp residues into the novel cofactor tryptophan tryptophylquinone, or TTQ, in the light chain (MauA) of methylamine dehydrogenase. While some analogous enzyme cofactors are produced autocatalytically from amino acids in the precursor polypeptide, TTQ is produced with aid of the maturation enzyme MauG. MauG is a di-heme enzyme with peroxidase activity, similar to di-heme cytochrome c peroxidases of other biological systems. Interestingly, the pair of modified Trp residues is conserved in MauA homologs in species that have no MauG homolog in the vicinity, suggesting no modification, autocatalytic modification, or a different modification enzyme.
Parent PropertyGenProp0075: protein modification, prosthetic groups and cofactors
GenProp0184: cofactor biosynthesis
Literature References
[ 1 ] Lee S, Shin S, Li X, Davidson V  Kinetic Mechanism for the Initial Steps in MauG-dependent Tryptophan Tryptophylquinone Biosynthesis.   Biochemistry. 2009 Feb 5.  PMID 19196017
[ 2 ]Davidson VL, Liu A  Tryptophan tryptophylquinone biosynthesis: A radical approach to posttranslational modification  Biochim Biophys Acta. 2012 Jan 28.  PMID 22314272

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
methylamine dehydrogenase, light chainMauAYESTIGR02659 (HMM): methylamine dehydrogenase (amicyanin) light chain
methylamine dehydrogenase heavy chainMauBYESTIGR02658 (HMM): methylamine dehydrogenase (amicyanin) heavy chain
methylamine dehydrogenase accessory protein MauDMauDYESTIGR02661 (HMM): methylamine dehydrogenase accessory protein MauD
TTQ maturation di-heme protein MauGMauGYESTIGR03791 (HMM): tryptophan tryptophylquinone biosynthesis enzyme MauG

Parent Properties
GenProp0075protein modification, prosthetic groups and cofactors
GenProp0184cofactor biosynthesis

Sibling Properties
GenProp0002coenzyme F420 utilization
GenProp0016selenocysteine system
GenProp0061lipoprotein system lgt/lsp/lnt
GenProp0127Tat (Sec-independent) protein export
GenProp0284cobalamin-utilizing enzymes
GenProp0295prokaryotic N-terminal cleavage/methylation, type IV pilin-like
GenProp0726selenium-dependent molybdenum hydroxylase system
GenProp0745lipoyl-protein attachment
GenProp0918anaerobic sulfatase/maturase system
GenProp0923mycothiol system
GenProp0933bacillithiol utilization
GenProp0938glycine radical enzyme system, YjjI/YjjW pair
GenProp0943pyruvate formate-lyase system
GenProp0001chorismate biosynthesis via shikimate
GenProp0030glutathione biosynthesis
GenProp0036biotin biosynthesis
GenProp0038tetrahydrofolate biosynthesis from GTP and PABA
GenProp0057NAD(P) biosynthesis from L-aspartate and DHAP
GenProp0112riboflavin, FAD and FMN from GTP and ribulose-5-P
GenProp0124pantothenate biosynthesis from aspartate and 2-oxoisovalerate
GenProp0136ubiquinone biosynthesis from chorismate, aerobic
GenProp0140iron-sulfur cluster assembly systems
GenProp0170coenzyme PQQ biosynthesis
GenProp0171coenzyme A biosynthesis from pantothenate
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0220uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0221protoporphyrin IX biosynthesis from uroporphyrinogen III
GenProp0222protoheme from protoporphyrin IX
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp02555-aminolevulinate biosynthesis
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis
GenProp0274coenzyme B12 biosynthesis - overview
GenProp0300photosynthetic cofactor biosynthesis
GenProp0466molybdopterin biosynthesis
GenProp0752ergothioneine biosynthesis
GenProp0753mycothiol biosynthesis
GenProp0759para-aminobenzoic acid (PABA) biosynthesis from chorismate
GenProp0791coenzyme F420 biosynthesis
GenProp07927,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis
GenProp0836menaquinone biosynthesis
GenProp0862pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway
GenProp0863pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway
GenProp0891coenzyme M biosynthesis
GenProp0917mycofactocin system
GenProp0927bacillithiol biosynthesis
GenProp1064ovothiol biosynthesis
GenProp1096coenzyme B biosynthesis