Genome Property Definition Page
| Accession | GenProp0466 | |
| Name | molybdopterin biosynthesis | |
| Type | PATHWAY | |
| Description | Molybdenum, in every enzyme containing it except nitrogenase, is a single atom coordinated by the two sulfur atoms of molybdopterin (MPT). MoaA and MoaC synthesize precursor Z from guanine. MoaD (supported by MoeB) and MoaE synthesize MPT from precursor Z. MoeA and MogA add molybdenum to the dithiolene of MPT. A molybdenum transport system (see GenProp0192) must also be present. In bacteria, MPT most often occurs as the derivative molybdopterin guanine dinucleotide (MGG); MobA catalyzes the addition of GMP to MPT. In hyperthermophiles, tungsten may substitute for molybdenum. In species with a member of family TIGR03309 (YqeB family), selenium can substitute for sulfur. | |
| JCVI Role | Molybdopterin | |
| Parent Property | GenProp0184: cofactor biosynthesis | |
| Literature References |
| |
| Gene Ontology Term | GO:0032324: molybdopterin cofactor biosynthetic process (biological_process) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| molybdenum cofactor biosynthesis protein A | moaA | YES | TIGR02666 (HMM): molybdenum cofactor biosynthesis protein A TIGR02668 (HMM): probable molybdenum cofactor biosynthesis protein A | GO:0032324: molybdopterin cofactor biosynthetic process GO:0032324: molybdopterin cofactor biosynthetic process |
| molybdenum cofactor biosynthesis protein B | moaB | NO | TIGR02667 (HMM): molybdenum cofactor biosynthesis protein B | GO:0032324: molybdopterin cofactor biosynthetic process |
| molybdenum cofactor biosynthesis protein C | moaC | YES | TIGR00581 (HMM): molybdenum cofactor biosynthesis protein C | GO:0032324: molybdopterin cofactor biosynthetic process |
| molybdopterin converting factor, subunit 1 | moaD | YES | TIGR01682 (HMM): molybdopterin converting factor, subunit 1 | GO:0032324: molybdopterin cofactor biosynthetic process |
| molybdopterin converting factor, subunit 2 | moaE | YES | PF02391 (HMM): molybdopterin converting factor, subunit 2 | GO:0032324: molybdopterin cofactor biosynthetic process |
| molybdopterin-guanine dinucleotide biosynthesis protein A | mobA | NO | TIGR02665 (HMM): molybdenum cofactor guanylyltransferase | GO:0032324: molybdopterin cofactor biosynthetic process |
| molybdopterin-guanine dinucleotide biosynthesis protein B | mobB | YES | TIGR00176 (HMM): molybdopterin-guanine dinucleotide biosynthesis protein B | GO:0032324: molybdopterin cofactor biosynthetic process |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0184 | cofactor biosynthesis |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0001 | chorismate biosynthesis via shikimate |
| GenProp0030 | glutathione biosynthesis |
| GenProp0036 | biotin biosynthesis |
| GenProp0038 | tetrahydrofolate biosynthesis from GTP and PABA |
| GenProp0057 | NAD(P) biosynthesis from L-aspartate and DHAP |
| GenProp0112 | riboflavin, FAD and FMN from GTP and ribulose-5-P |
| GenProp0124 | pantothenate biosynthesis from aspartate and 2-oxoisovalerate |
| GenProp0136 | ubiquinone biosynthesis from chorismate, aerobic |
| GenProp0140 | iron-sulfur cluster assembly systems |
| GenProp0170 | coenzyme PQQ biosynthesis |
| GenProp0171 | coenzyme A biosynthesis from pantothenate |
| GenProp0194 | siroheme biosynthesis from uroporphrinogen-III |
| GenProp0220 | uroporhyrinogen III biosynthesis from 5-aminolevulinate |
| GenProp0221 | protoporphyrin IX biosynthesis from uroporphyrinogen III |
| GenProp0222 | protoheme from protoporphyrin IX |
| GenProp0250 | thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly |
| GenProp0255 | 5-aminolevulinate biosynthesis |
| GenProp0261 | thiamin pyrophosphate (TPP) de novo biosynthesis |
| GenProp0274 | coenzyme B12 biosynthesis - overview |
| GenProp0300 | photosynthetic cofactor biosynthesis |
| GenProp0752 | ergothioneine biosynthesis |
| GenProp0753 | mycothiol biosynthesis |
| GenProp0759 | para-aminobenzoic acid (PABA) biosynthesis from chorismate |
| GenProp0791 | coenzyme F420 biosynthesis |
| GenProp0792 | 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis |
| GenProp0836 | menaquinone biosynthesis |
| GenProp0860 | tryptophan tryptophylquinone modification of methylamine dehydrogenase |
| GenProp0862 | pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway |
| GenProp0863 | pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway |
| GenProp0891 | coenzyme M biosynthesis |
| GenProp0917 | mycofactocin system |
| GenProp0927 | bacillithiol biosynthesis |
| GenProp1064 | ovothiol biosynthesis |
| GenProp1096 | coenzyme B biosynthesis |