Genome Property Definition Page
| Accession | GenProp0057 | |
| Name | NAD(P) biosynthesis from L-aspartate and DHAP | |
| Type | PATHWAY | |
| Description | Nicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine dinucleotide phosphate (NADP+) also known as pyridine nucleotides, are cofactors involved in numerous redox reactions through reversible reactions to their reduced forms NADH and NADPH. In bacteria, NAD+ is synthesized in a 5 step reaction (NadABCDE) from L-aspartate and NADP+ is made from NAD+ by the action of NAD kinase. In mammals, an altenative pathway exists in which the intermediate quinolinate is made from L-tryptophan. NAD+ may also be recycled from nicotinamide after nucleosidease cleavage, or synthesized from imported nicotinate (niacin). | |
| JCVI Role | Pyridine nucleotides | |
| Parent Property | GenProp0184: cofactor biosynthesis | |
| Literature References |
| |
| Web References | KEGG: Nicotinate and nicotinamide metabolism | |
| Gene Ontology Term | GO:0009435: NAD biosynthetic process (biological_process) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| L-aspartate oxidase (or dehydrogenase) | 1 | NO | TIGR00551 (HMM): L-aspartate oxidase TIGR03855 (HMM): aspartate dehydrogenase | GO:0009435: NAD biosynthetic process GO:0009435: NAD biosynthetic process |
| quinolinate synthetase complex, A subunit | 2 | YES | TIGR00550 (HMM): quinolinate synthetase complex, A subunit | GO:0009435: NAD biosynthetic process |
| nicotinate-nucleotide pyrophosphorylase | 3 | YES | TIGR00078 (HMM): nicotinate-nucleotide diphosphorylase (carboxylating) | GO:0009435: NAD biosynthetic process |
| nicotinate nucleotide adenylyltransferase | 4 | YES | TIGR00482 (HMM): nicotinate (nicotinamide) nucleotide adenylyltransferase TIGR01527 (HMM): nicotinamide-nucleotide adenylyltransferase | GO:0009435: NAD biosynthetic process GO:0009435: NAD biosynthetic process |
| NAD+ synthetase | 5 | YES | TIGR00552 (HMM): NAD+ synthetase | GO:0009435: NAD biosynthetic process |
| NAD kinase | 6 | NO | PF01513 (HMM): NAD(+)/NADH kinase 2.7.1.23 (ECNUM) | GO:0009435: NAD biosynthetic process GO:0009435: NAD biosynthetic process |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0184 | cofactor biosynthesis |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0001 | chorismate biosynthesis via shikimate |
| GenProp0030 | glutathione biosynthesis |
| GenProp0036 | biotin biosynthesis |
| GenProp0038 | tetrahydrofolate biosynthesis from GTP and PABA |
| GenProp0112 | riboflavin, FAD and FMN from GTP and ribulose-5-P |
| GenProp0124 | pantothenate biosynthesis from aspartate and 2-oxoisovalerate |
| GenProp0136 | ubiquinone biosynthesis from chorismate, aerobic |
| GenProp0140 | iron-sulfur cluster assembly systems |
| GenProp0170 | coenzyme PQQ biosynthesis |
| GenProp0171 | coenzyme A biosynthesis from pantothenate |
| GenProp0194 | siroheme biosynthesis from uroporphrinogen-III |
| GenProp0220 | uroporhyrinogen III biosynthesis from 5-aminolevulinate |
| GenProp0221 | protoporphyrin IX biosynthesis from uroporphyrinogen III |
| GenProp0222 | protoheme from protoporphyrin IX |
| GenProp0250 | thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly |
| GenProp0255 | 5-aminolevulinate biosynthesis |
| GenProp0261 | thiamin pyrophosphate (TPP) de novo biosynthesis |
| GenProp0274 | coenzyme B12 biosynthesis - overview |
| GenProp0300 | photosynthetic cofactor biosynthesis |
| GenProp0466 | molybdopterin biosynthesis |
| GenProp0752 | ergothioneine biosynthesis |
| GenProp0753 | mycothiol biosynthesis |
| GenProp0759 | para-aminobenzoic acid (PABA) biosynthesis from chorismate |
| GenProp0791 | coenzyme F420 biosynthesis |
| GenProp0792 | 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis |
| GenProp0836 | menaquinone biosynthesis |
| GenProp0860 | tryptophan tryptophylquinone modification of methylamine dehydrogenase |
| GenProp0862 | pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway |
| GenProp0863 | pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway |
| GenProp0891 | coenzyme M biosynthesis |
| GenProp0917 | mycofactocin system |
| GenProp0927 | bacillithiol biosynthesis |
| GenProp1064 | ovothiol biosynthesis |
| GenProp1096 | coenzyme B biosynthesis |