Genome Property Definition Page

NameNAD(P) biosynthesis from L-aspartate and DHAP
DescriptionNicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine dinucleotide phosphate (NADP+) also known as pyridine nucleotides, are cofactors involved in numerous redox reactions through reversible reactions to their reduced forms NADH and NADPH. In bacteria, NAD+ is synthesized in a 5 step reaction (NadABCDE) from L-aspartate and NADP+ is made from NAD+ by the action of NAD kinase. In mammals, an altenative pathway exists in which the intermediate quinolinate is made from L-tryptophan. NAD+ may also be recycled from nicotinamide after nucleosidease cleavage, or synthesized from imported nicotinate (niacin).
JCVI RolePyridine nucleotides
Parent PropertyGenProp0184: cofactor biosynthesis
Literature References
[ 1 ] Yang Z, Savchenko A, Yakunin A, Zhang R, Edwards A, Arrowsmith C, Tong L   Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643.   J Biol Chem. 2003 Mar 7;278(10):8804-8. Epub 2002 Dec 21.  PMID 12496312
Web ReferencesKEGG: Nicotinate and nicotinamide metabolism
Gene Ontology TermGO:0009435: NAD biosynthetic process (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
L-aspartate oxidase (or dehydrogenase)1NOTIGR00551 (HMM): L-aspartate oxidase
TIGR03855 (HMM): aspartate dehydrogenase
GO:0009435: NAD biosynthetic process
GO:0009435: NAD biosynthetic process
quinolinate synthetase complex, A subunit2YESTIGR00550 (HMM): quinolinate synthetase complex, A subunitGO:0009435: NAD biosynthetic process
nicotinate-nucleotide pyrophosphorylase3YESTIGR00078 (HMM): nicotinate-nucleotide diphosphorylase (carboxylating)GO:0009435: NAD biosynthetic process
nicotinate nucleotide adenylyltransferase4YESTIGR00482 (HMM): nicotinate (nicotinamide) nucleotide adenylyltransferase
TIGR01527 (HMM): nicotinamide-nucleotide adenylyltransferase
GO:0009435: NAD biosynthetic process
GO:0009435: NAD biosynthetic process
NAD+ synthetase5YESTIGR00552 (HMM): NAD+ synthetaseGO:0009435: NAD biosynthetic process
NAD kinase6NOPF01513 (HMM): NAD(+)/NADH kinase (ECNUM)
GO:0009435: NAD biosynthetic process
GO:0009435: NAD biosynthetic process

Parent Properties
GenProp0184cofactor biosynthesis

Sibling Properties
GenProp0001chorismate biosynthesis via shikimate
GenProp0030glutathione biosynthesis
GenProp0036biotin biosynthesis
GenProp0038tetrahydrofolate biosynthesis from GTP and PABA
GenProp0112riboflavin, FAD and FMN from GTP and ribulose-5-P
GenProp0124pantothenate biosynthesis from aspartate and 2-oxoisovalerate
GenProp0136ubiquinone biosynthesis from chorismate, aerobic
GenProp0140iron-sulfur cluster assembly systems
GenProp0170coenzyme PQQ biosynthesis
GenProp0171coenzyme A biosynthesis from pantothenate
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0220uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0221protoporphyrin IX biosynthesis from uroporphyrinogen III
GenProp0222protoheme from protoporphyrin IX
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp02555-aminolevulinate biosynthesis
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis
GenProp0274coenzyme B12 biosynthesis - overview
GenProp0300photosynthetic cofactor biosynthesis
GenProp0466molybdopterin biosynthesis
GenProp0752ergothioneine biosynthesis
GenProp0753mycothiol biosynthesis
GenProp0759para-aminobenzoic acid (PABA) biosynthesis from chorismate
GenProp0791coenzyme F420 biosynthesis
GenProp07927,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis
GenProp0836menaquinone biosynthesis
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0862pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway
GenProp0863pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway
GenProp0891coenzyme M biosynthesis
GenProp0917mycofactocin system
GenProp0927bacillithiol biosynthesis
GenProp1064ovothiol biosynthesis
GenProp1096coenzyme B biosynthesis