Genome Property Definition Page
| Accession | GenProp0038 | |
| Name | tetrahydrofolate biosynthesis from GTP and PABA | |
| Type | PATHWAY | |
| Description | Polyglutamylated tetrahydrofolate is the central cofactor of one-carbon metabolism and is biosynthesized from GTP, para-aminobenzoate (from chorismate), and glutamate in a six step reaction.[1] The first enzyme, GTP cyclohydrolase I, in the biosynthesis of tetrahydrofolate in prokaryotes, of tetrahydrobiopterin in vertebrates, and of pteridine-containing pigments in insects catalizes dihydroneopterin triphosphate from GTP. This pathway is carried out by 6 enzymes, and the complete pathway is absent in animals. | |
| JCVI Role | Folic acid | |
| Parent Property | GenProp0184: cofactor biosynthesis | |
| Literature References |
| |
| Web References | KEGG: Folate Biosynthesis IUBMB: Folate Biosynthesis (early stages) IUBMB: Folate Biosynthesis (late stages) | |
| Gene Ontology Term | GO:0046654: tetrahydrofolate biosynthetic process (biological_process) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| GTP cyclohydrolase I | 1 | NO | TIGR00063 (HMM): GTP cyclohydrolase I | GO:0046654: tetrahydrofolate biosynthetic process |
| dihydroneopterin aldolase | 2 | YES | TIGR00525 (HMM): dihydroneopterin aldolase | GO:0046654: tetrahydrofolate biosynthetic process |
| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | 3 | YES | TIGR01498 (HMM): 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase | GO:0046654: tetrahydrofolate biosynthetic process |
| dihydropteroate synthase | 4 | YES | TIGR01496 (HMM): dihydropteroate synthase | GO:0046654: tetrahydrofolate biosynthetic process |
| dihydrofolate synthase | 5 | YES | TIGR01499 (HMM): bifunctional protein FolC | GO:0046654: tetrahydrofolate biosynthetic process |
| dihydrofolate reductase | 6 | YES | PF00186 (HMM): dihydrofolate reductase | GO:0046654: tetrahydrofolate biosynthetic process |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0184 | cofactor biosynthesis |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0001 | chorismate biosynthesis via shikimate |
| GenProp0030 | glutathione biosynthesis |
| GenProp0036 | biotin biosynthesis |
| GenProp0057 | NAD(P) biosynthesis from L-aspartate and DHAP |
| GenProp0112 | riboflavin, FAD and FMN from GTP and ribulose-5-P |
| GenProp0124 | pantothenate biosynthesis from aspartate and 2-oxoisovalerate |
| GenProp0136 | ubiquinone biosynthesis from chorismate, aerobic |
| GenProp0140 | iron-sulfur cluster assembly systems |
| GenProp0170 | coenzyme PQQ biosynthesis |
| GenProp0171 | coenzyme A biosynthesis from pantothenate |
| GenProp0194 | siroheme biosynthesis from uroporphrinogen-III |
| GenProp0220 | uroporhyrinogen III biosynthesis from 5-aminolevulinate |
| GenProp0221 | protoporphyrin IX biosynthesis from uroporphyrinogen III |
| GenProp0222 | protoheme from protoporphyrin IX |
| GenProp0250 | thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly |
| GenProp0255 | 5-aminolevulinate biosynthesis |
| GenProp0261 | thiamin pyrophosphate (TPP) de novo biosynthesis |
| GenProp0274 | coenzyme B12 biosynthesis - overview |
| GenProp0300 | photosynthetic cofactor biosynthesis |
| GenProp0466 | molybdopterin biosynthesis |
| GenProp0752 | ergothioneine biosynthesis |
| GenProp0753 | mycothiol biosynthesis |
| GenProp0759 | para-aminobenzoic acid (PABA) biosynthesis from chorismate |
| GenProp0791 | coenzyme F420 biosynthesis |
| GenProp0792 | 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis |
| GenProp0836 | menaquinone biosynthesis |
| GenProp0860 | tryptophan tryptophylquinone modification of methylamine dehydrogenase |
| GenProp0862 | pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway |
| GenProp0863 | pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway |
| GenProp0891 | coenzyme M biosynthesis |
| GenProp0917 | mycofactocin system |
| GenProp0927 | bacillithiol biosynthesis |
| GenProp1064 | ovothiol biosynthesis |
| GenProp1096 | coenzyme B biosynthesis |