Genome Property Definition Page
| Accession | GenProp0030 |
| Name | glutathione biosynthesis |
| Type | PATHWAY |
| Description | YES NO Glutathione (GSH) is gamma-Glu-Cys-Gly, a thiol whose -SH group is an important reductant in many systems. Some species use thiols other than glutathione: mycothione in Mycobacterium tuberculosis, gamma-glutamylcysteine in Halobacterium, trypanothione in trypanosomes. Cysteine and CoA may also serve. Glutathione biosynthesis is accomplished by two enzymes. First, glutamate--cysteine ligase links the gamma-COOH of Glu to the NH2 of Cys. Next, glutathione synthase creates a peptide bond from the COOH of Cys to the NH2 of Gly. Species that synthesize glutathione are likely to have a reductase for oxidized glutathione and a number of glutathione-dependent enzymes. |
| JCVI Role | Glutathione and analogs |
| Parent Property | GenProp0184: cofactor biosynthesis GenProp0196: sulfur metabolism |
| Web References | KEGG: Glutathione Metabolism |
| Gene Ontology Term | GO:0006750: glutathione biosynthetic process (biological_process) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| glutamate--cysteine ligase | GSH_1 | YES | TIGR01434 (HMM): glutamate--cysteine ligase TIGR01436 (HMM): glutamate--cysteine ligase PF03074 (HMM): glutamate-cysteine ligase, catalytic subunit TIGR02049 (HMM): glutamate--cysteine ligase TIGR02048 (HMM): putative glutamate--cysteine ligase TIGR01435 (HMM): glutamate--cysteine ligase/glutathione synthase | GO:0006750: glutathione biosynthetic process GO:0006750: glutathione biosynthetic process GO:0006750: glutathione biosynthetic process GO:0006750: glutathione biosynthetic process GO:0006750: glutathione biosynthetic process GO:0006750: glutathione biosynthetic process |
| glutathione synthetase | GSH_2 | YES | TIGR01380 (HMM): glutathione synthase TIGR01986 (HMM): glutathione synthetase TIGR01435 (HMM): glutamate--cysteine ligase/glutathione synthase | GO:0006750: glutathione biosynthetic process GO:0006750: glutathione biosynthetic process GO:0006750: glutathione biosynthetic process |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0184 | cofactor biosynthesis |
| GenProp0196 | sulfur metabolism |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0001 | chorismate biosynthesis via shikimate |
| GenProp0036 | biotin biosynthesis |
| GenProp0038 | tetrahydrofolate biosynthesis from GTP and PABA |
| GenProp0057 | NAD(P) biosynthesis from L-aspartate and DHAP |
| GenProp0112 | riboflavin, FAD and FMN from GTP and ribulose-5-P |
| GenProp0124 | pantothenate biosynthesis from aspartate and 2-oxoisovalerate |
| GenProp0136 | ubiquinone biosynthesis from chorismate, aerobic |
| GenProp0140 | iron-sulfur cluster assembly systems |
| GenProp0170 | coenzyme PQQ biosynthesis |
| GenProp0171 | coenzyme A biosynthesis from pantothenate |
| GenProp0194 | siroheme biosynthesis from uroporphrinogen-III |
| GenProp0220 | uroporhyrinogen III biosynthesis from 5-aminolevulinate |
| GenProp0221 | protoporphyrin IX biosynthesis from uroporphyrinogen III |
| GenProp0222 | protoheme from protoporphyrin IX |
| GenProp0250 | thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly |
| GenProp0255 | 5-aminolevulinate biosynthesis |
| GenProp0261 | thiamin pyrophosphate (TPP) de novo biosynthesis |
| GenProp0274 | coenzyme B12 biosynthesis - overview |
| GenProp0300 | photosynthetic cofactor biosynthesis |
| GenProp0466 | molybdopterin biosynthesis |
| GenProp0752 | ergothioneine biosynthesis |
| GenProp0753 | mycothiol biosynthesis |
| GenProp0759 | para-aminobenzoic acid (PABA) biosynthesis from chorismate |
| GenProp0791 | coenzyme F420 biosynthesis |
| GenProp0792 | 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis |
| GenProp0836 | menaquinone biosynthesis |
| GenProp0860 | tryptophan tryptophylquinone modification of methylamine dehydrogenase |
| GenProp0862 | pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway |
| GenProp0863 | pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway |
| GenProp0891 | coenzyme M biosynthesis |
| GenProp0917 | mycofactocin system |
| GenProp0927 | bacillithiol biosynthesis |
| GenProp1064 | ovothiol biosynthesis |
| GenProp1096 | coenzyme B biosynthesis |
| GenProp0149 | sulfate reduction to sulfide, assimilatory |
| GenProp0155 | dissimilatory sulfate reduction |
| GenProp0161 | methionine biosynthesis from homoserine |
| GenProp0182 | reduction of oxidized methionine |
| GenProp0191 | sulfate/thiosulfate ABC transporter |
| GenProp0624 | sulfite reductase complex, Salmonella/Clostridium type |
| GenProp0654 | intracellular sulfur oxidation |
| GenProp0729 | methionine salvage from methylthioadenosine |