Genome Property Definition Page
| Accession | GenProp0136 | |
| Name | ubiquinone biosynthesis from chorismate, aerobic | |
| Type | PATHWAY | |
| Description | Ubiquinone, an electron and hydrogen transport cofactor important for aerobic respiration and photosynthesis, is synthesized in bacteria from chorismate and polyprenyl pyrophosphates of varying lengths [1]. Knock out of the three hydroxylation steps requiring molecular oxygen results in anaerobic synthesis of ubiquinone, indicating the presence of an alternative system [2]. In yeast and animals a different pathway exists starting from 4-hydroxyphenylpyruvate, having latter steps in common with the bacterial pathway [3]. In addition to ubiquinone, bacteria may contain menaquinone and/or phylloquinone which together make up their quinone pool [1]. | |
| JCVI Role | Menaquinone and ubiquinone | |
| Parent Property | GenProp0184: cofactor biosynthesis GenProp0838: lipid biosynthesis | |
| Literature References |
| |
| Web References | KEGG: Ubiquinone metabolism | |
| Gene Ontology Term | GO:0006744: ubiquinone biosynthetic process (biological_process) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| 4-hydroxybenzoate prenyltransferase | UbiA | YES | TIGR01475 (HMM): putative 4-hydroxybenzoate polyprenyltransferase TIGR01474 (HMM): 4-hydroxybenzoate polyprenyl transferase | GO:0006744: ubiquinone biosynthetic process GO:0006744: ubiquinone biosynthetic process |
| 2-polyprenylphenol hydroxylase | UbiB | YES | TIGR01982 (HMM): 2-polyprenylphenol 6-hydroxylase | GO:0006744: ubiquinone biosynthetic process |
| chorismate-pyruvate lyase | UbiC | NO | PF04345 (HMM): chorismate lyase | |
| 3-prenyl-4-hydroxybenzoate decarboxylase | UbiD/X | YES | PF01977 (HMM): 3-octaprenyl-4-hydroxybenzoate carboxy-lyase TIGR00421 (HMM): polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases | GO:0006744: ubiquinone biosynthetic process GO:0006744: ubiquinone biosynthetic process |
| ubiquinone biosynthesis C-methyltransferase | UbiE | YES | TIGR01934 (HMM): ubiquinone/menaquinone biosynthesis methyltransferase | |
| ubiquinone biosynthesis 4- and 5-hydroxylases | UbiF/H | YES | TIGR01988 (HMM): ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family PF03232 (HMM): ubiquinone biosynthesis protein COQ7 | GO:0006744: ubiquinone biosynthetic process GO:0006744: ubiquinone biosynthetic process |
| 3-demethylubiquinone-9 3-methyltransferase | UbiG | YES | TIGR01983 (HMM): 3-demethylubiquinone-9 3-O-methyltransferase | GO:0006744: ubiquinone biosynthetic process |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0184 | cofactor biosynthesis |
| GenProp0838 | lipid biosynthesis |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0001 | chorismate biosynthesis via shikimate |
| GenProp0030 | glutathione biosynthesis |
| GenProp0036 | biotin biosynthesis |
| GenProp0038 | tetrahydrofolate biosynthesis from GTP and PABA |
| GenProp0057 | NAD(P) biosynthesis from L-aspartate and DHAP |
| GenProp0112 | riboflavin, FAD and FMN from GTP and ribulose-5-P |
| GenProp0124 | pantothenate biosynthesis from aspartate and 2-oxoisovalerate |
| GenProp0140 | iron-sulfur cluster assembly systems |
| GenProp0170 | coenzyme PQQ biosynthesis |
| GenProp0171 | coenzyme A biosynthesis from pantothenate |
| GenProp0194 | siroheme biosynthesis from uroporphrinogen-III |
| GenProp0220 | uroporhyrinogen III biosynthesis from 5-aminolevulinate |
| GenProp0221 | protoporphyrin IX biosynthesis from uroporphyrinogen III |
| GenProp0222 | protoheme from protoporphyrin IX |
| GenProp0250 | thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly |
| GenProp0255 | 5-aminolevulinate biosynthesis |
| GenProp0261 | thiamin pyrophosphate (TPP) de novo biosynthesis |
| GenProp0274 | coenzyme B12 biosynthesis - overview |
| GenProp0300 | photosynthetic cofactor biosynthesis |
| GenProp0466 | molybdopterin biosynthesis |
| GenProp0752 | ergothioneine biosynthesis |
| GenProp0753 | mycothiol biosynthesis |
| GenProp0759 | para-aminobenzoic acid (PABA) biosynthesis from chorismate |
| GenProp0791 | coenzyme F420 biosynthesis |
| GenProp0792 | 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis |
| GenProp0836 | menaquinone biosynthesis |
| GenProp0860 | tryptophan tryptophylquinone modification of methylamine dehydrogenase |
| GenProp0862 | pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway |
| GenProp0863 | pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway |
| GenProp0891 | coenzyme M biosynthesis |
| GenProp0917 | mycofactocin system |
| GenProp0927 | bacillithiol biosynthesis |
| GenProp1064 | ovothiol biosynthesis |
| GenProp1096 | coenzyme B biosynthesis |
| GenProp0046 | IPP biosynthesis |
| GenProp0297 | lipopolysaccharide biosynthesis |
| GenProp0299 | fatty acid biosynthesis |
| GenProp0758 | lycopene biosynthesis from IPP |
| GenProp0761 | hopanoid lipid biosynthesis |
| GenProp0837 | 1-acylglycerol-3-phosphate biosynthesis, PlsX/Y pathway |