Genome Property Definition Page

Namebacillithiol biosynthesis
DescriptionThis property describes the biosynthesis of bacillithiol, a thiol analog of glutathione and mycothiol. Bacillithiol is a 398-Da alpha-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid
JCVI RoleGlutathione and analogs
Parent PropertyGenProp0184: cofactor biosynthesis
Literature References
[ 1 ]Gaballa A, Newton GL, Antelmann H, Parsonage D, Upton H, Rawat M, Claiborne A, Fahey RC, Helmann JD  Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli.  Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6482-6. Epub 2010 Mar 22.  PMID 20308541
[ 2 ]Parsonage D, Newton GL, Holder RC, Wallace BD, Paige C, Hamilton CJ, Dos Santos PC, Redinbo MR, Reid SD, Claiborne A  Characterization of the N-Acetyl-alpha-d-glucosaminyl l-Malate Synthase and Deacetylase Functions for Bacillithiol Biosynthesis in Bacillus anthracis .  Biochemistry. 2010 Sep 28;49(38):8398-414.  PMID 20799687
Gene Ontology TermGO:0071793: bacillithiol biosynthetic process (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
glycosyltransferase BshABshAYESTIGR03999 (HMM): N-acetyl-alpha-D-glucosaminyl L-malate synthase BshAGO:0071793: bacillithiol biosynthetic process
N-acetylhydrolase BshBBshBYESTIGR04000 (HMM): bacillithiol biosynthesis deacetylase BshB2
TIGR04001 (HMM): bacillithiol biosynthesis deacetylase BshB1
GO:0071793: bacillithiol biosynthetic process
GO:0071793: bacillithiol biosynthetic process
cysteine-adding enzyme BshCBshCYESTIGR03998 (HMM): bacillithiol biosynthesis cysteine-adding enzyme BshCGO:0071793: bacillithiol biosynthetic process

Parent Properties
GenProp0184cofactor biosynthesis

Sibling Properties
GenProp0001chorismate biosynthesis via shikimate
GenProp0030glutathione biosynthesis
GenProp0036biotin biosynthesis
GenProp0038tetrahydrofolate biosynthesis from GTP and PABA
GenProp0057NAD(P) biosynthesis from L-aspartate and DHAP
GenProp0112riboflavin, FAD and FMN from GTP and ribulose-5-P
GenProp0124pantothenate biosynthesis from aspartate and 2-oxoisovalerate
GenProp0136ubiquinone biosynthesis from chorismate, aerobic
GenProp0140iron-sulfur cluster assembly systems
GenProp0170coenzyme PQQ biosynthesis
GenProp0171coenzyme A biosynthesis from pantothenate
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0220uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0221protoporphyrin IX biosynthesis from uroporphyrinogen III
GenProp0222protoheme from protoporphyrin IX
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp02555-aminolevulinate biosynthesis
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis
GenProp0274coenzyme B12 biosynthesis - overview
GenProp0300photosynthetic cofactor biosynthesis
GenProp0466molybdopterin biosynthesis
GenProp0752ergothioneine biosynthesis
GenProp0753mycothiol biosynthesis
GenProp0759para-aminobenzoic acid (PABA) biosynthesis from chorismate
GenProp0791coenzyme F420 biosynthesis
GenProp07927,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis
GenProp0836menaquinone biosynthesis
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0862pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway
GenProp0863pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway
GenProp0891coenzyme M biosynthesis
GenProp0917mycofactocin system
GenProp1064ovothiol biosynthesis
GenProp1096coenzyme B biosynthesis