Genome Property Definition Page

Nameovothiol biosynthesis
DescriptionThe first step in ovothiol A biosynthesis is conversion of cysteine and histidine to 5-histidylcysteine sulfoxide conjugate by 5-histidylcysteine sulfoxide synthase. The conjugate is trimmed by a currently unknown mechanism (perhaps different enzymes in different species) to 5-thiohistidine, and is N-methylated at the pi position of the imidazole ring. Many OvaA (5-histidylcysteine sulfoxide synthase) have an additional C-terminal methyltransferase domain likely to provide this methyltransferase activity. Ovothiols B and C differ from ovothiol A by having additional methylations of the histidine-derived amino group.
JCVI RoleGlutathione and analogs
Parent PropertyGenProp0184: cofactor biosynthesis
Literature References
[ 1 ]Braunshausen A, Seebeck FP  Identification and characterization of the first ovothiol biosynthetic enzyme.  J Am Chem Soc. 2011 Feb 16;133(6):1757-9.  PMID 21247153

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
4-mercaptohistidine N1-methyltransferaseovo_CterYESTIGR04345 (HMM): putative 4-mercaptohistidine N1-methyltranferase
5-histidylcysteine sulfoxide synthaseovo_NterYESTIGR04344 (HMM): 5-histidylcysteine sulfoxide synthase

Parent Properties
GenProp0184cofactor biosynthesis

Sibling Properties
GenProp0001chorismate biosynthesis via shikimate
GenProp0030glutathione biosynthesis
GenProp0036biotin biosynthesis
GenProp0038tetrahydrofolate biosynthesis from GTP and PABA
GenProp0057NAD(P) biosynthesis from L-aspartate and DHAP
GenProp0112riboflavin, FAD and FMN from GTP and ribulose-5-P
GenProp0124pantothenate biosynthesis from aspartate and 2-oxoisovalerate
GenProp0136ubiquinone biosynthesis from chorismate, aerobic
GenProp0140iron-sulfur cluster assembly systems
GenProp0170coenzyme PQQ biosynthesis
GenProp0171coenzyme A biosynthesis from pantothenate
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0220uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0221protoporphyrin IX biosynthesis from uroporphyrinogen III
GenProp0222protoheme from protoporphyrin IX
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp02555-aminolevulinate biosynthesis
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis
GenProp0274coenzyme B12 biosynthesis - overview
GenProp0300photosynthetic cofactor biosynthesis
GenProp0466molybdopterin biosynthesis
GenProp0752ergothioneine biosynthesis
GenProp0753mycothiol biosynthesis
GenProp0759para-aminobenzoic acid (PABA) biosynthesis from chorismate
GenProp0791coenzyme F420 biosynthesis
GenProp07927,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis
GenProp0836menaquinone biosynthesis
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0862pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway
GenProp0863pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway
GenProp0891coenzyme M biosynthesis
GenProp0917mycofactocin system
GenProp0927bacillithiol biosynthesis
GenProp1096coenzyme B biosynthesis