Genome Property Definition Page
| Accession | GenProp1064 | |
| Name | ovothiol biosynthesis | |
| Type | PATHWAY | |
| Description | The first step in ovothiol A biosynthesis is conversion of cysteine and histidine to 5-histidylcysteine sulfoxide conjugate by 5-histidylcysteine sulfoxide synthase. The conjugate is trimmed by a currently unknown mechanism (perhaps different enzymes in different species) to 5-thiohistidine, and is N-methylated at the pi position of the imidazole ring. Many OvaA (5-histidylcysteine sulfoxide synthase) have an additional C-terminal methyltransferase domain likely to provide this methyltransferase activity. Ovothiols B and C differ from ovothiol A by having additional methylations of the histidine-derived amino group. | |
| JCVI Role | Glutathione and analogs | |
| Parent Property | GenProp0184: cofactor biosynthesis | |
| Literature References |
|
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| 4-mercaptohistidine N1-methyltransferase | ovo_Cter | YES | TIGR04345 (HMM): putative 4-mercaptohistidine N1-methyltranferase | |
| 5-histidylcysteine sulfoxide synthase | ovo_Nter | YES | TIGR04344 (HMM): 5-histidylcysteine sulfoxide synthase |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0184 | cofactor biosynthesis |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0001 | chorismate biosynthesis via shikimate |
| GenProp0030 | glutathione biosynthesis |
| GenProp0036 | biotin biosynthesis |
| GenProp0038 | tetrahydrofolate biosynthesis from GTP and PABA |
| GenProp0057 | NAD(P) biosynthesis from L-aspartate and DHAP |
| GenProp0112 | riboflavin, FAD and FMN from GTP and ribulose-5-P |
| GenProp0124 | pantothenate biosynthesis from aspartate and 2-oxoisovalerate |
| GenProp0136 | ubiquinone biosynthesis from chorismate, aerobic |
| GenProp0140 | iron-sulfur cluster assembly systems |
| GenProp0170 | coenzyme PQQ biosynthesis |
| GenProp0171 | coenzyme A biosynthesis from pantothenate |
| GenProp0194 | siroheme biosynthesis from uroporphrinogen-III |
| GenProp0220 | uroporhyrinogen III biosynthesis from 5-aminolevulinate |
| GenProp0221 | protoporphyrin IX biosynthesis from uroporphyrinogen III |
| GenProp0222 | protoheme from protoporphyrin IX |
| GenProp0250 | thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly |
| GenProp0255 | 5-aminolevulinate biosynthesis |
| GenProp0261 | thiamin pyrophosphate (TPP) de novo biosynthesis |
| GenProp0274 | coenzyme B12 biosynthesis - overview |
| GenProp0300 | photosynthetic cofactor biosynthesis |
| GenProp0466 | molybdopterin biosynthesis |
| GenProp0752 | ergothioneine biosynthesis |
| GenProp0753 | mycothiol biosynthesis |
| GenProp0759 | para-aminobenzoic acid (PABA) biosynthesis from chorismate |
| GenProp0791 | coenzyme F420 biosynthesis |
| GenProp0792 | 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis |
| GenProp0836 | menaquinone biosynthesis |
| GenProp0860 | tryptophan tryptophylquinone modification of methylamine dehydrogenase |
| GenProp0862 | pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway |
| GenProp0863 | pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway |
| GenProp0891 | coenzyme M biosynthesis |
| GenProp0917 | mycofactocin system |
| GenProp0927 | bacillithiol biosynthesis |
| GenProp1096 | coenzyme B biosynthesis |