Genome Property Definition Page
Accession | GenProp0917 | |
Name | mycofactocin system | |
Type | SYSTEM | |
Description | This Genome Property describes the proposed mycofactocin system, in which the four absolutely conserved elements are a radical SAM protein, a glycosyltransferase, a small protein with a strongly conserved central motif, and a very small protein with an invariant C-terminal motif GCVY. This last component, the proposed mycofactocin precursor MftA, often is not apparent because of faulty gene calling. Species with this system in addition always have at least a few examples (usually co-clustered) of nicotinoproteins with tightly bound NAD(P) cofactors that cannot be exchanged, requiring an extrinsic mechanism (such as the artifical electron acceptor NDMA) to be able to cycle. Mycofactocin is proposed to undergo modification and become the required electron exchange cofactor. | |
JCVI Role | Other | |
Parent Property | GenProp0184: cofactor biosynthesis | |
Literature References |
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Gene Ontology Term | GO:0031179: peptide modification (biological_process) GO:0051188: cofactor biosynthetic process (biological_process) GO:0051193: regulation of cofactor metabolic process (biological_process) GO:0055114: oxidation-reduction process (biological_process) |
Components
Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
---|---|---|---|---|
oxidoreductase, FAD/FMN-binding | ac_AD_4 | NO | TIGR03997 (HMM): mycofactocin system FadH/OYE family oxidoreductase 2 TIGR03996 (HMM): mycofactocin system FadH/OYE family oxidoreductase 1 | GO:0055114: oxidation-reduction process GO:0051188: cofactor biosynthetic process GO:0031179: peptide modification |
dehydrogenase, Rv0697 family | ac_aux1 | NO | TIGR03970 (HMM): dehydrogenase, Rv0697 family TIGR04542 (HMM): GMC family mycofactocin-associated oxidreductase | GO:0055114: oxidation-reduction process GO:0051188: cofactor biosynthetic process GO:0031179: peptide modification |
mycofactocin precursor | mftA | YES | TIGR03969 (HMM): mycofactocin precursor | GO:0051188: cofactor biosynthetic process GO:0031179: peptide modification |
RPExGFAL protein | mftB | YES | TIGR03967 (HMM): putative mycofactocin binding protein MftB | GO:0051188: cofactor biosynthetic process GO:0031179: peptide modification |
radical SAM mycofactocin maturase | mftCSAM | YES | TIGR03962 (HMM): mycofactocin radical SAM maturase | GO:0051188: cofactor biosynthetic process GO:0031179: peptide modification |
heme/FMN protein, | mftDflv | YES | TIGR03966 (HMM): heme/flavin dehydrogenase, mycofactocin system | GO:0055114: oxidation-reduction process |
creatininase family protein | mftEcre | YES | TIGR03964 (HMM): mycofactocin system creatininase family protein | GO:0051188: cofactor biosynthetic process GO:0031179: peptide modification |
glycosyltransferase | mftFgly | YES | TIGR03965 (HMM): mycofactocin system glycosyltransferase | GO:0051188: cofactor biosynthetic process GO:0031179: peptide modification |
mycofactocin system transcriptional regulator | mftR | NO | TIGR03968 (HMM): mycofactocin system transcriptional regulator | GO:0051193: regulation of cofactor metabolic process |
dehydrogenase, SDR family | mft_AD1 | NO | TIGR03971 (HMM): SDR family mycofactocin-dependent oxidoreductase TIGR04504 (HMM): SDR family mycofactocin-dependent oxidoreductase | GO:0055114: oxidation-reduction process GO:0051188: cofactor biosynthetic process GO:0031179: peptide modification |
dehydrogenase, Rxyl_3153 family | mft_AD2 | YES | TIGR03989 (HMM): NDMA-dependent alcohol dehydrogenase, Rxyl_3153 family | GO:0055114: oxidation-reduction process |
dehydrogenase, iron-activated family | mft_AD3 | NO | PF00465 (HMM-CLUST): alcohol dehydrogenase, iron-containing TIGR04266 (HMM): NDMA-dependent methanol dehydrogenase | GO:0055114: oxidation-reduction process GO:0055114: oxidation-reduction process |
Parent Properties
Accession | Name |
---|---|
GenProp0184 | cofactor biosynthesis |
Sibling Properties
Accession | Name |
---|---|
GenProp0001 | chorismate biosynthesis via shikimate |
GenProp0030 | glutathione biosynthesis |
GenProp0036 | biotin biosynthesis |
GenProp0038 | tetrahydrofolate biosynthesis from GTP and PABA |
GenProp0057 | NAD(P) biosynthesis from L-aspartate and DHAP |
GenProp0112 | riboflavin, FAD and FMN from GTP and ribulose-5-P |
GenProp0124 | pantothenate biosynthesis from aspartate and 2-oxoisovalerate |
GenProp0136 | ubiquinone biosynthesis from chorismate, aerobic |
GenProp0140 | iron-sulfur cluster assembly systems |
GenProp0170 | coenzyme PQQ biosynthesis |
GenProp0171 | coenzyme A biosynthesis from pantothenate |
GenProp0194 | siroheme biosynthesis from uroporphrinogen-III |
GenProp0220 | uroporhyrinogen III biosynthesis from 5-aminolevulinate |
GenProp0221 | protoporphyrin IX biosynthesis from uroporphyrinogen III |
GenProp0222 | protoheme from protoporphyrin IX |
GenProp0250 | thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly |
GenProp0255 | 5-aminolevulinate biosynthesis |
GenProp0261 | thiamin pyrophosphate (TPP) de novo biosynthesis |
GenProp0274 | coenzyme B12 biosynthesis - overview |
GenProp0300 | photosynthetic cofactor biosynthesis |
GenProp0466 | molybdopterin biosynthesis |
GenProp0752 | ergothioneine biosynthesis |
GenProp0753 | mycothiol biosynthesis |
GenProp0759 | para-aminobenzoic acid (PABA) biosynthesis from chorismate |
GenProp0791 | coenzyme F420 biosynthesis |
GenProp0792 | 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis |
GenProp0836 | menaquinone biosynthesis |
GenProp0860 | tryptophan tryptophylquinone modification of methylamine dehydrogenase |
GenProp0862 | pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway |
GenProp0863 | pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway |
GenProp0891 | coenzyme M biosynthesis |
GenProp0927 | bacillithiol biosynthesis |
GenProp1064 | ovothiol biosynthesis |
GenProp1096 | coenzyme B biosynthesis |