Genome Property Definition Page

Namecoenzyme A biosynthesis from pantothenate
DescriptionThis property represents a 5-step pathway for the biosynthesis of coenzyme A (CoA) from pantothenate. The first step, catalyzed by pantothenate kinase, is carried out by at least two different known protein families. One is found in most bacteria, including E. coli (TIGR00554). Another is present in eukaryotes and in a few Gram-positive bacteria (e.g. Staphylococcus aureus, Bacillus anthracis) (TIGR00555). The enzyme, if present, has not been identified in a number of species. The second and third enzymes are usually found together in a multifunctional protein, phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase, once thought to affect DNA metabolism as well. In Streptococcus and allies, and some other species, the enzymes are encoded in tandem genes rather than fused. CoaD and CoaE are, respectively, pantetheine-phosphate adenylyltransferase and dephospho-CoA kinase.
JCVI RolePantothenate and coenzyme A
Parent PropertyGenProp0184: cofactor biosynthesis
Web ReferencesIUBMB: Coenzyme A Biosynthesis (late stages)
Gene Ontology TermGO:0015937: coenzyme A biosynthetic process (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
pantothenate kinasecoaANOTIGR00554 (HMM): pantothenate kinase
TIGR00555 (HMM): pantothenate kinase
TIGR00671 (HMM): pantothenate kinase, type III
GO:0015937: coenzyme A biosynthetic process
GO:0015937: coenzyme A biosynthetic process
GO:0015937: coenzyme A biosynthetic process
phosphopantothenate--cysteine ligasecoaBYESTIGR00521 (HMM): phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase
TIGR02114 (HMM): phosphopantothenate--cysteine ligase
GO:0015937: coenzyme A biosynthetic process
GO:0015937: coenzyme A biosynthetic process
phosphopantothenoylcysteine decarboxylasecoaCYESTIGR00521 (HMM): phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase
TIGR02113 (HMM): phosphopantothenoylcysteine decarboxylase
GO:0015937: coenzyme A biosynthetic process
GO:0015937: coenzyme A biosynthetic process
pantetheine-phosphate adenylyltransferasecoaDYESTIGR01510 (HMM): pantetheine-phosphate adenylyltransferaseGO:0015937: coenzyme A biosynthetic process
dephospho-CoA kinasecoaEYESTIGR00152 (HMM): dephospho-CoA kinaseGO:0015937: coenzyme A biosynthetic process
sodium/pantothenate symporterpanFNOTIGR02119 (HMM): sodium/pantothenate symporterGO:0015937: coenzyme A biosynthetic process

Parent Properties
GenProp0184cofactor biosynthesis

Sibling Properties
GenProp0001chorismate biosynthesis via shikimate
GenProp0030glutathione biosynthesis
GenProp0036biotin biosynthesis
GenProp0038tetrahydrofolate biosynthesis from GTP and PABA
GenProp0057NAD(P) biosynthesis from L-aspartate and DHAP
GenProp0112riboflavin, FAD and FMN from GTP and ribulose-5-P
GenProp0124pantothenate biosynthesis from aspartate and 2-oxoisovalerate
GenProp0136ubiquinone biosynthesis from chorismate, aerobic
GenProp0140iron-sulfur cluster assembly systems
GenProp0170coenzyme PQQ biosynthesis
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0220uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0221protoporphyrin IX biosynthesis from uroporphyrinogen III
GenProp0222protoheme from protoporphyrin IX
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp02555-aminolevulinate biosynthesis
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis
GenProp0274coenzyme B12 biosynthesis - overview
GenProp0300photosynthetic cofactor biosynthesis
GenProp0466molybdopterin biosynthesis
GenProp0752ergothioneine biosynthesis
GenProp0753mycothiol biosynthesis
GenProp0759para-aminobenzoic acid (PABA) biosynthesis from chorismate
GenProp0791coenzyme F420 biosynthesis
GenProp07927,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis
GenProp0836menaquinone biosynthesis
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0862pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway
GenProp0863pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway
GenProp0891coenzyme M biosynthesis
GenProp0917mycofactocin system
GenProp0927bacillithiol biosynthesis
GenProp1064ovothiol biosynthesis
GenProp1096coenzyme B biosynthesis