Genome Property Definition Page
| Accession | GenProp0250 | |
| Name | thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly | |
| Type | PATHWAY | |
| Description | This property describes de novo synthesis of the thiazole moiety of thiamine, hydroxyethylthiazole (HET). This requires more distinct proteins than that of the pyrimidine moeity, hydromethylpyrimidine (HMP). Phosphorylated forms of HET and HMP are connected by ThiE as thiamine phosphate and converted eventually to the active form thiamine pyrophosphate, TPP. HET biosynthesis requires the small ThiS protein, the C-terminus of which becomes modified transiently by a sulfur atom from cysteine. ThiG is required, along with either ThiH in species where tyrosine is a precursor or ThiO in species where glycine is a precursor. ThiF, although required biosynthetically, is not readily separated from MoeB, a molybdopterin biosynthesis protein, and so is not built into the rule as a required component. Either IscS or NifS must be present, but this requirement also is not included in the rule. The ThiI gene is required, but also serves in formation of a tRNA modified site in species that do not make HET. This property represents and alternative to HET uptake as a means to obtain the thiazole component for thiamine biosynthesis. | |
| JCVI Role | Thiamine | |
| Parent Property | GenProp0184: cofactor biosynthesis GenProp0261: thiamin pyrophosphate (TPP) de novo biosynthesis | |
| Literature References |
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| Gene Ontology Term | GO:0009228: thiamine biosynthetic process (biological_process) GO:0018131: oxazole or thiazole biosynthetic process (biological_process) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| ThiH (Tyr) or ThiO (Gly) | H_or_O | YES | TIGR02352 (HMM): glycine oxidase ThiO TIGR02351 (HMM): thiazole biosynthesis protein ThiH | GO:0009228: thiamine biosynthetic process GO:0018131: oxazole or thiazole biosynthetic process GO:0009228: thiamine biosynthetic process GO:0018131: oxazole or thiazole biosynthetic process |
| ThiF protein | ThiF | NO | TIGR02354 (HMM): thiamine biosynthesis protein ThiF TIGR02356 (HMM): thiazole biosynthesis adenylyltransferase ThiF | GO:0009228: thiamine biosynthetic process GO:0018131: oxazole or thiazole biosynthetic process GO:0009228: thiamine biosynthetic process GO:0018131: oxazole or thiazole biosynthetic process |
| ThiG protein | ThiG | YES | PF05690 (HMM): thiazole biosynthesis protein ThiG | GO:0009228: thiamine biosynthetic process GO:0018131: oxazole or thiazole biosynthetic process |
| ThiI protein | ThiI | YES | TIGR04271 (HMM): thiazole biosynthesis domain | GO:0009228: thiamine biosynthetic process GO:0018131: oxazole or thiazole biosynthetic process |
| ThiS protein | ThiS | YES | TIGR01683 (HMM): thiamine biosynthesis protein ThiS | GO:0009228: thiamine biosynthetic process GO:0018131: oxazole or thiazole biosynthetic process |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0184 | cofactor biosynthesis |
| GenProp0261 | thiamin pyrophosphate (TPP) de novo biosynthesis |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0001 | chorismate biosynthesis via shikimate |
| GenProp0030 | glutathione biosynthesis |
| GenProp0036 | biotin biosynthesis |
| GenProp0038 | tetrahydrofolate biosynthesis from GTP and PABA |
| GenProp0057 | NAD(P) biosynthesis from L-aspartate and DHAP |
| GenProp0112 | riboflavin, FAD and FMN from GTP and ribulose-5-P |
| GenProp0124 | pantothenate biosynthesis from aspartate and 2-oxoisovalerate |
| GenProp0136 | ubiquinone biosynthesis from chorismate, aerobic |
| GenProp0140 | iron-sulfur cluster assembly systems |
| GenProp0170 | coenzyme PQQ biosynthesis |
| GenProp0171 | coenzyme A biosynthesis from pantothenate |
| GenProp0194 | siroheme biosynthesis from uroporphrinogen-III |
| GenProp0220 | uroporhyrinogen III biosynthesis from 5-aminolevulinate |
| GenProp0221 | protoporphyrin IX biosynthesis from uroporphyrinogen III |
| GenProp0222 | protoheme from protoporphyrin IX |
| GenProp0255 | 5-aminolevulinate biosynthesis |
| GenProp0261 | thiamin pyrophosphate (TPP) de novo biosynthesis |
| GenProp0274 | coenzyme B12 biosynthesis - overview |
| GenProp0300 | photosynthetic cofactor biosynthesis |
| GenProp0466 | molybdopterin biosynthesis |
| GenProp0752 | ergothioneine biosynthesis |
| GenProp0753 | mycothiol biosynthesis |
| GenProp0759 | para-aminobenzoic acid (PABA) biosynthesis from chorismate |
| GenProp0791 | coenzyme F420 biosynthesis |
| GenProp0792 | 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis |
| GenProp0836 | menaquinone biosynthesis |
| GenProp0860 | tryptophan tryptophylquinone modification of methylamine dehydrogenase |
| GenProp0862 | pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway |
| GenProp0863 | pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway |
| GenProp0891 | coenzyme M biosynthesis |
| GenProp0917 | mycofactocin system |
| GenProp0927 | bacillithiol biosynthesis |
| GenProp1064 | ovothiol biosynthesis |
| GenProp1096 | coenzyme B biosynthesis |
| GenProp0253 | thiamine: hydroxymethylpyrimidine pyrophosphate from aminoimidazole ribotide |
| GenProp0254 | thiamine: TPP from HMP-PP and HET-P |