Genome Property Definition Page

Namecoenzyme M biosynthesis
DescriptionCoenzyme M (2-mercaptoethanesulfonic acid) acts in methanogenesis in methanogenic archaea. It is also used as a carrier in a bacterium, Xanthobacter autotrophicus Py2, in aerobic propylene metabolism. Pathways differ from Methanococcus jannaschi to Methanosarcina acetivorans, and again to Xanthobacter autotrophicus Py2. This Genome Property represents the parent property.
JCVI RoleOther
Parent PropertyGenProp0184: cofactor biosynthesis
Literature References
[ 1 ] Graham DE, Taylor SM, Wolf RZ, Namboori SC  Convergent evolution of coenzyme M biosynthesis in the Methanosarcinales: cysteate synthase evolved from an ancestral threonine synthase.   Biochem J. 2009 Sep 17.  PMID 19761441
[ 2 ] Graupner M, Xu H, White RH   Identification of the gene encoding sulfopyruvate decarboxylase, an enzyme involved in biosynthesis of coenzyme M.   J Bacteriol. 2000 Sep;182(17):4862-7.  PMID 10940029
[ 3 ]Graham DE  2-oxoacid metabolism in methanogenic CoM and CoB biosynthesis.  Methods Enzymol. 2011;494:301-26. doi: 10.1016/B978-0-12-385112-3.00015-9.  PMID 21402221

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
sulfopyruvate biosynthesisM_S_pyrYESGenProp0892 (GENPROP): sulfopyruvate biosynthesis from phoshoenolpyruvate
GenProp0893 (GENPROP): sulfopyruvate biosynthesis via L-cysteate
sulfopyruvate decarboxylase, alpha subunitM_comDYESTIGR03845 (HMM): sulfopyruvate decarboxylase, alpha subunit
sulfopyruvate decarboxylase, beta subunitM_comEYESTIGR03846 (HMM): sulfopyruvate decarboxylase, beta subunit
2690 (RULE_BASE)

Parent Properties
GenProp0184cofactor biosynthesis

Sibling Properties
GenProp0001chorismate biosynthesis via shikimate
GenProp0030glutathione biosynthesis
GenProp0036biotin biosynthesis
GenProp0038tetrahydrofolate biosynthesis from GTP and PABA
GenProp0057NAD(P) biosynthesis from L-aspartate and DHAP
GenProp0112riboflavin, FAD and FMN from GTP and ribulose-5-P
GenProp0124pantothenate biosynthesis from aspartate and 2-oxoisovalerate
GenProp0136ubiquinone biosynthesis from chorismate, aerobic
GenProp0140iron-sulfur cluster assembly systems
GenProp0170coenzyme PQQ biosynthesis
GenProp0171coenzyme A biosynthesis from pantothenate
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0220uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0221protoporphyrin IX biosynthesis from uroporphyrinogen III
GenProp0222protoheme from protoporphyrin IX
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp02555-aminolevulinate biosynthesis
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis
GenProp0274coenzyme B12 biosynthesis - overview
GenProp0300photosynthetic cofactor biosynthesis
GenProp0466molybdopterin biosynthesis
GenProp0752ergothioneine biosynthesis
GenProp0753mycothiol biosynthesis
GenProp0759para-aminobenzoic acid (PABA) biosynthesis from chorismate
GenProp0791coenzyme F420 biosynthesis
GenProp07927,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis
GenProp0836menaquinone biosynthesis
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0862pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway
GenProp0863pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway
GenProp0917mycofactocin system
GenProp0927bacillithiol biosynthesis
GenProp1064ovothiol biosynthesis
GenProp1096coenzyme B biosynthesis