Genome Property Definition Page

Namesulfopyruvate biosynthesis from phoshoenolpyruvate
DescriptionThis pathway represents the first three steps in coenzyme M biosynthesis as it occurs in Methanococcus jannaschii. Alternative pathway to sulfopyruvate, from L-phosphoserine via L-cysteate, has been described in Methanosarcina acetivorans.
JCVI RoleOther
Literature References
[ 1 ] Graupner M, Xu H, White RH   Identification of an archaeal 2-hydroxy acid dehydrogenase catalyzing reactions involved in coenzyme biosynthesis in methanoarchaea.   J Bacteriol. 2000 Jul;182(13):3688-92.  PMID 10850983

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
(2R)-phospho-3-sulfolactate synthaseM_comAYES2692 (RULE_BASE)

TIGR03849 (HMM): phosphosulfolactate synthase
2-phosphosulfolactate phosphataseM_comBYESTIGR00298 (HMM): 2-phosphosulfolactate phosphatase
(R)-2-hydroxyacid dehydrogenaseM_comCNO2691 (RULE_BASE)