| Accession | GenProp1096 |
| Name | coenzyme B biosynthesis |
| Type | PATHWAY |
| Description | Coenzyme B is 7-mercaptoheptanoylthreoninephosphate. Coenzyme M and coenzyme B for a heterodisulfide during a key step in methanogenesis. This property is inactive: equivalog-level HMMs to provide evidence for computing this pathway are not yet available. |
| JCVI Role | Other |
| Parent Property | GenProp0184: cofactor biosynthesis
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| Literature References | [ 1 ]Howell DM, Harich K, Xu H, White RH Alpha-keto acid chain elongation reactions involved in the biosynthesis of coenzyme B (7-mercaptoheptanoyl threonine phosphate) in methanogenic Archaea. Biochemistry. 1998 Jul 14;37(28):10108-17. PMID 9665716
[ 2 ]Howell DM, Graupner M, Xu H, White RH Identification of enzymes homologous to isocitrate dehydrogenase that are involved in coenzyme B and leucine biosynthesis in methanoarchaea. J Bacteriol. 2000 Sep;182(17):5013-6. PMID 10940051
[ 3 ]Drevland RM, Jia Y, Palmer DR, Graham DE Methanogen homoaconitase catalyzes both hydrolyase reactions in coenzyme B biosynthesis. J Biol Chem. 2008 Oct 24;283(43):28888-96. doi: 10.1074/jbc.M802159200. PMID 18765671
[ 4 ]Graham DE 2-oxoacid metabolism in methanogenic CoM and CoB biosynthesis. Methods Enzymol. 2011;494:301-26. doi: 10.1016/B978-0-12-385112-3.00015-9. PMID 21402221
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| Gene Ontology Term | GO:0019298: coenzyme B biosynthetic process (biological_process)
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