Genome Property Definition Page
| Accession | GenProp0124 |
| Name | pantothenate biosynthesis from aspartate and 2-oxoisovalerate |
| Type | PATHWAY |
| Description | This Genome Property tracks four proteins of pantothenate biosynthesis from aspartate. PanD, aspartate 1-decarboxylase, EC 4.1.1.11, makes beta-alanine. PanB, 3-methyl-2-oxobutanoate hydroxymethyltransferase, makes 2-dehydropantoate from 3-methyl-2-oxobutanoate. PanC, pantoate--beta-alanine ligase, EC 6.3.2.1, produces (R)-pantothenate from beta-alanine and (R)-pantoate. The genes for these three proteins tend to be clustered in bacterial genomes. The protein family distribution for a fourth component, PanE, is very different. The production of (R)-pantoate from 2-dehydropantoate can occur in more than one way (NADH or NADPH-dependent), and may be catalyzed by enzymes that may have additional important substrates (an example is the D-mandelate dehydrogenase of Enterococcus faecalis) and several such enzymes may be found in a genome. |
| JCVI Role | Pantothenate and coenzyme A |
| Parent Property | GenProp0184: cofactor biosynthesis |
| Web References | IUBMB: Coenzyme A Biosynthesis (early stages) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| 3-methyl-2-oxobutanoate hydroxymethyltransferase | panB | YES | TIGR00222 (HMM): 3-methyl-2-oxobutanoate hydroxymethyltransferase | |
| pantoate--beta-alanine ligase | panC | YES | TIGR00018 (HMM): pantoate--beta-alanine ligase | |
| aspartate 1-decarboxylase | panD | YES | TIGR00223 (HMM): aspartate 1-decarboxylase TIGR03799 (HMM): putative pyridoxal-dependent aspartate 1-decarboxylase | |
| 2-dehydropantoate 2-reductase | panE | NO | TIGR00745 (HMM): 2-dehydropantoate 2-reductase |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0184 | cofactor biosynthesis |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0001 | chorismate biosynthesis via shikimate |
| GenProp0030 | glutathione biosynthesis |
| GenProp0036 | biotin biosynthesis |
| GenProp0038 | tetrahydrofolate biosynthesis from GTP and PABA |
| GenProp0057 | NAD(P) biosynthesis from L-aspartate and DHAP |
| GenProp0112 | riboflavin, FAD and FMN from GTP and ribulose-5-P |
| GenProp0136 | ubiquinone biosynthesis from chorismate, aerobic |
| GenProp0140 | iron-sulfur cluster assembly systems |
| GenProp0170 | coenzyme PQQ biosynthesis |
| GenProp0171 | coenzyme A biosynthesis from pantothenate |
| GenProp0194 | siroheme biosynthesis from uroporphrinogen-III |
| GenProp0220 | uroporhyrinogen III biosynthesis from 5-aminolevulinate |
| GenProp0221 | protoporphyrin IX biosynthesis from uroporphyrinogen III |
| GenProp0222 | protoheme from protoporphyrin IX |
| GenProp0250 | thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly |
| GenProp0255 | 5-aminolevulinate biosynthesis |
| GenProp0261 | thiamin pyrophosphate (TPP) de novo biosynthesis |
| GenProp0274 | coenzyme B12 biosynthesis - overview |
| GenProp0300 | photosynthetic cofactor biosynthesis |
| GenProp0466 | molybdopterin biosynthesis |
| GenProp0752 | ergothioneine biosynthesis |
| GenProp0753 | mycothiol biosynthesis |
| GenProp0759 | para-aminobenzoic acid (PABA) biosynthesis from chorismate |
| GenProp0791 | coenzyme F420 biosynthesis |
| GenProp0792 | 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis |
| GenProp0836 | menaquinone biosynthesis |
| GenProp0860 | tryptophan tryptophylquinone modification of methylamine dehydrogenase |
| GenProp0862 | pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway |
| GenProp0863 | pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway |
| GenProp0891 | coenzyme M biosynthesis |
| GenProp0917 | mycofactocin system |
| GenProp0927 | bacillithiol biosynthesis |
| GenProp1064 | ovothiol biosynthesis |
| GenProp1096 | coenzyme B biosynthesis |