Genome Property Definition Page
| Accession | GenProp0274 |
| Name | coenzyme B12 biosynthesis - overview |
| Type | METAPATH |
| Description | This property summarizes and contains the various pathways and systems required for the complete biosynthesis of vitamin B12, 5-deoxyadenosyl cobalamin, from 5-aminolevulinate, S-adenosyl methionine, glutamine, cobalt, ATP, 1-amino-2-propanol, GDP, nicotinate mononucleotide and dimethylbenzimidazole. |
| Parent Property | GenProp0184: cofactor biosynthesis |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms | Branch |
|---|---|---|---|---|---|
| Uroporphyrinogen III from 5-aminolevulinate: GenProp0220 | 1 | YES | GenProp0220 (GENPROP): uroporhyrinogen III biosynthesis from 5-aminolevulinate | 1 | |
| cobyrinic acid diamide biosynthesis, aerobic pathway: GenProp0113 | 2a | YES | GenProp0113 (GENPROP): cobyrinic acid diamide biosynthesis, aerobic pathway | aerobic | |
| cobyrinic acid diamide biosynthesis, anaerobic pathway | 2b | YES | GenProp0275 (GENPROP): cobyrinic acid diamide biosynthesis, anaerobic pathway | anaerob | |
| B12 from cob(II)yrinate diamide and alpha-ribazole: GenProp0269 | 4 | YES | GenProp0269 (GENPROP): coenzyme B12 biosynthesis from cob(II)yrinate diamide | 1 | |
| alpha-ribazole from nicotinate mononucleotide and dimethylbenzimidazole: GenProp0270 | 5 | NO | GenProp0270 (GENPROP): | 1 | |
| Cobalt import systems: GenProp0279 | 6 | YES | GenProp0279 (GENPROP): cobalt import systems | 1 | |
| cobalamin-utilizing enzymes: GenProp0284 | B12-enz | YES | GenProp0284 (GENPROP): cobalamin-utilizing enzymes | 1 |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0184 | cofactor biosynthesis |
Child Properties
| Accession | Name |
|---|---|
| GenProp0113 | cobyrinic acid diamide biosynthesis, aerobic pathway |
| GenProp0220 | uroporhyrinogen III biosynthesis from 5-aminolevulinate |
| GenProp0269 | coenzyme B12 biosynthesis from cob(II)yrinate diamide |
| GenProp0275 | cobyrinic acid diamide biosynthesis, anaerobic pathway |
| GenProp0277 | cobalt import system (ABC transporter: 3.A.1.18.1) |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0001 | chorismate biosynthesis via shikimate |
| GenProp0030 | glutathione biosynthesis |
| GenProp0036 | biotin biosynthesis |
| GenProp0038 | tetrahydrofolate biosynthesis from GTP and PABA |
| GenProp0057 | NAD(P) biosynthesis from L-aspartate and DHAP |
| GenProp0112 | riboflavin, FAD and FMN from GTP and ribulose-5-P |
| GenProp0124 | pantothenate biosynthesis from aspartate and 2-oxoisovalerate |
| GenProp0136 | ubiquinone biosynthesis from chorismate, aerobic |
| GenProp0140 | iron-sulfur cluster assembly systems |
| GenProp0170 | coenzyme PQQ biosynthesis |
| GenProp0171 | coenzyme A biosynthesis from pantothenate |
| GenProp0194 | siroheme biosynthesis from uroporphrinogen-III |
| GenProp0220 | uroporhyrinogen III biosynthesis from 5-aminolevulinate |
| GenProp0221 | protoporphyrin IX biosynthesis from uroporphyrinogen III |
| GenProp0222 | protoheme from protoporphyrin IX |
| GenProp0250 | thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly |
| GenProp0255 | 5-aminolevulinate biosynthesis |
| GenProp0261 | thiamin pyrophosphate (TPP) de novo biosynthesis |
| GenProp0300 | photosynthetic cofactor biosynthesis |
| GenProp0466 | molybdopterin biosynthesis |
| GenProp0752 | ergothioneine biosynthesis |
| GenProp0753 | mycothiol biosynthesis |
| GenProp0759 | para-aminobenzoic acid (PABA) biosynthesis from chorismate |
| GenProp0791 | coenzyme F420 biosynthesis |
| GenProp0792 | 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis |
| GenProp0836 | menaquinone biosynthesis |
| GenProp0860 | tryptophan tryptophylquinone modification of methylamine dehydrogenase |
| GenProp0862 | pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway |
| GenProp0863 | pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway |
| GenProp0891 | coenzyme M biosynthesis |
| GenProp0917 | mycofactocin system |
| GenProp0927 | bacillithiol biosynthesis |
| GenProp1064 | ovothiol biosynthesis |
| GenProp1096 | coenzyme B biosynthesis |