Genome Property Definition Page

AccessionGenProp0001
Namechorismate biosynthesis via shikimate
TypePATHWAY
DescriptionChorismate is the final common intermediate in the biosynthesis of phenylalanine, tyrosine and tryptophan (the aromatic amino acids) as well as menaquinone, ubiquinone, salicylate and phenazine. Chorismate is synthesized via a seven-step pathway starting from the precursors D-erythrose 4-phosphate and phosphoenolpyruvate. This pathway is widely distributed among microorganisms. Certain methanogenic euarchaeota appear to be missing the first two steps of the pathway - these may be catalyzed by as of yet uncharacterized enzymes.
JCVI RoleOther
Parent PropertyGenProp0126: amino acid biosynthesis
GenProp0184: cofactor biosynthesis
Literature References
[ 1 ]Knaggs AR.  The biosynthesis of shikimate metabolites.  Nat Prod Rep. 2003 Feb;20(1):119-36.  PMID 12636087
Web ReferencesKEGG: Phenylalanine, Tyrosine and Tryptophan Biosynthesis
IUBMB: Shikimate and Chorismate Biosynthesis
EcoCyc: E. coli K-12 Pathway: chorismate biosynthesis
MetaCyc: chorismate biosynthesis
Gene Ontology TermGO:0009423: chorismate biosynthetic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
phospho-2-dehydro-3-deoxyheptonate aldolase1YESTIGR00034 (HMM): 3-deoxy-7-phosphoheptulonate synthase
TIGR01358 (HMM): 3-deoxy-7-phosphoheptulonate synthase
TIGR01361 (HMM): 3-deoxy-7-phosphoheptulonate synthase
TIGR01949 (HMM): predicted phospho-2-dehydro-3-deoxyheptonate aldolase		GO:0009423: chorismate biosynthetic process
GO:0009423: chorismate biosynthetic process
GO:0009423: chorismate biosynthetic process
GO:0009423: chorismate biosynthetic process
3-dehydroquinate synthase2YESTIGR01357 (HMM): 3-dehydroquinate synthase
PF01959 (HMM): 3-dehydroquinate synthase		GO:0009423: chorismate biosynthetic process
GO:0009423: chorismate biosynthetic process
3-dehydroquinate dehydratase3YESTIGR01088 (HMM): 3-dehydroquinate dehydratase, type II
TIGR01093 (HMM): 3-dehydroquinate dehydratase, type I		GO:0009423: chorismate biosynthetic process
GO:0009423: chorismate biosynthetic process
shikimate 5-dehydrogenase4YESTIGR00507 (HMM): shikimate dehydrogenase
TIGR01809 (HMM): shikimate-5-dehydrogenase		GO:0009423: chorismate biosynthetic process
GO:0009423: chorismate biosynthetic process
shikimate kinase5YESPF01202 (HMM): shikimate kinase
TIGR01920 (HMM): shikimate kinase		GO:0009423: chorismate biosynthetic process
GO:0009423: chorismate biosynthetic process
3-phosphoshikimate 1-carboxyvinyltransferase6YESTIGR01356 (HMM): 3-phosphoshikimate 1-carboxyvinyltransferaseGO:0009423: chorismate biosynthetic process
chorismate synthase7YESTIGR00033 (HMM): chorismate synthaseGO:0009423: chorismate biosynthetic process

Parent Properties
AccessionName
GenProp0126amino acid biosynthesis
GenProp0184cofactor biosynthesis


Sibling Properties
AccessionName
GenProp0016selenocysteine system
GenProp0037tryptophan biosynthesis from ribose-5-phosphate
GenProp0039phenylalanine biosynthesis from chorismate
GenProp0045tyrosine biosynthesis from chorismate
GenProp0087arginine biosynthesis from glutatmate via N-acetylglutamate
GenProp0109histidine biosynthesis from ribose-5-phosphate
GenProp0111proline biosynthesis from glutamate
GenProp0117arginine biosynthesis from ornithine, carbamoyl-p and aspartate
GenProp0118ornithine biosynthesis from glutamate, acetylated branch
GenProp0159threonine biosynthesis from aspartate semialdehyde
GenProp0160aspartate semialdehyde biosynthesis from aspartate
GenProp0161methionine biosynthesis from homoserine
GenProp0162isoleucine biosynthesis from threonine and pyruvate
GenProp0163valine biosynthesis from pyruvate
GenProp0164leucine biosynthesis from pyruvate and acetyl-CoA
GenProp0178glycine cleavage system
GenProp0199lysine biosynthesis
GenProp0304cysteine biosynthesis, tRNA-dependent
GenProp0305cysteine biosynthesis
GenProp0729methionine salvage from methylthioadenosine
GenProp0797selenocysteinyl-tRNA, PSTK/SepSecS pathway
GenProp0030glutathione biosynthesis
GenProp0036biotin biosynthesis
GenProp0038tetrahydrofolate biosynthesis from GTP and PABA
GenProp0057NAD(P) biosynthesis from L-aspartate and DHAP
GenProp0112riboflavin, FAD and FMN from GTP and ribulose-5-P
GenProp0124pantothenate biosynthesis from aspartate and 2-oxoisovalerate
GenProp0136ubiquinone biosynthesis from chorismate, aerobic
GenProp0140iron-sulfur cluster assembly systems
GenProp0170coenzyme PQQ biosynthesis
GenProp0171coenzyme A biosynthesis from pantothenate
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0220uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0221protoporphyrin IX biosynthesis from uroporphyrinogen III
GenProp0222protoheme from protoporphyrin IX
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp02555-aminolevulinate biosynthesis
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis
GenProp0274coenzyme B12 biosynthesis - overview
GenProp0300photosynthetic cofactor biosynthesis
GenProp0466molybdopterin biosynthesis
GenProp0752ergothioneine biosynthesis
GenProp0753mycothiol biosynthesis
GenProp0759para-aminobenzoic acid (PABA) biosynthesis from chorismate
GenProp0791coenzyme F420 biosynthesis
GenProp07927,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis
GenProp0836menaquinone biosynthesis
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0862pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway
GenProp0863pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway
GenProp0891coenzyme M biosynthesis
GenProp0917mycofactocin system
GenProp0927bacillithiol biosynthesis
GenProp1064ovothiol biosynthesis
GenProp1096coenzyme B biosynthesis