Genome Property Definition Page
| Accession | GenProp0036 |
| Name | biotin biosynthesis |
| Type | PATHWAY |
| Description | Biotin is an essential cofactor for many carboxylation (addition of C02) reactions. This property reflects biosynthesis from pimeloyl-CoA. The source of pimeloyl-CoA may vary. BioF (EC 2.3.1.47, 8-amino-7-oxononanoate synthase, also called 7-keto-8-aminopelargonic acid synthetase) converts pimeloyl-CoA to 8-amino-7-oxononanoate. BioA (EC 2.6.1.62, adenosylmethionine-8-amino-7-oxononanoate aminotransferase) converts the product to 7,8-diaminononanoate, from which BioD (EC 6.3.3.3, dethiobiotin synthase) makes dethiobiotin. BioB (EC 2.8.1.6, biotin synthase) then makes biotin itself. Enzymes such as BioH involved in pimeloyl-CoA biosynthesis typically receive biotin-related annotations but may also appear in genomes in which biotin is not synthesized and pimeloyl-CoA is used for something else. |
| JCVI Role | Biotin |
| Parent Property | GenProp0184: cofactor biosynthesis GenProp0196: sulfur metabolism |
| Web References | KEGG: Biotin Metabolism |
| Gene Ontology Term | GO:0006355: regulation of transcription, DNA-dependent (biological_process) GO:0009102: biotin biosynthetic process (biological_process) GO:0009102: biotin biosynthetic process (biological_process) GO:0018065: protein-cofactor linkage (biological_process) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| 8-amino-7-oxononanoate synthase | 2 | YES | TIGR00858 (HMM): 8-amino-7-oxononanoate synthase | GO:0009102: biotin biosynthetic process |
| adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 3 | YES | TIGR00508 (HMM): adenosylmethionine-8-amino-7-oxononanoate transaminase | GO:0009102: biotin biosynthetic process |
| dethiobiotin synthase | 4 | YES | TIGR00347 (HMM): dethiobiotin synthase | GO:0009102: biotin biosynthetic process |
| biotin synthase | 5 | YES | TIGR00433 (HMM): biotin synthase | GO:0009102: biotin biosynthetic process |
| BioC | bioC | NO | TIGR02072 (HMM): malonyl-acyl carrier protein O-methyltransferase BioC | GO:0009102: biotin biosynthetic process |
| bioH protein | bioH | NO | TIGR01738 (HMM): pimelyl-[acyl-carrier protein] methyl ester esterase | GO:0009102: biotin biosynthetic process |
| BioY family protein | bioY | NO | PF02632 (HMM): BioY family | GO:0009102: biotin biosynthetic process |
| biotin ligase domain protein | birA | NO | TIGR00121 (HMM): biotin--[acetyl-CoA-carboxylase] ligase | GO:0018065: protein-cofactor linkage |
| biotin repressor | represso | NO | TIGR00122 (HMM): biotin operon repressor | GO:0006355: regulation of transcription, DNA-dependent GO:0009102: biotin biosynthetic process |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0184 | cofactor biosynthesis |
| GenProp0196 | sulfur metabolism |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0001 | chorismate biosynthesis via shikimate |
| GenProp0030 | glutathione biosynthesis |
| GenProp0038 | tetrahydrofolate biosynthesis from GTP and PABA |
| GenProp0057 | NAD(P) biosynthesis from L-aspartate and DHAP |
| GenProp0112 | riboflavin, FAD and FMN from GTP and ribulose-5-P |
| GenProp0124 | pantothenate biosynthesis from aspartate and 2-oxoisovalerate |
| GenProp0136 | ubiquinone biosynthesis from chorismate, aerobic |
| GenProp0140 | iron-sulfur cluster assembly systems |
| GenProp0170 | coenzyme PQQ biosynthesis |
| GenProp0171 | coenzyme A biosynthesis from pantothenate |
| GenProp0194 | siroheme biosynthesis from uroporphrinogen-III |
| GenProp0220 | uroporhyrinogen III biosynthesis from 5-aminolevulinate |
| GenProp0221 | protoporphyrin IX biosynthesis from uroporphyrinogen III |
| GenProp0222 | protoheme from protoporphyrin IX |
| GenProp0250 | thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly |
| GenProp0255 | 5-aminolevulinate biosynthesis |
| GenProp0261 | thiamin pyrophosphate (TPP) de novo biosynthesis |
| GenProp0274 | coenzyme B12 biosynthesis - overview |
| GenProp0300 | photosynthetic cofactor biosynthesis |
| GenProp0466 | molybdopterin biosynthesis |
| GenProp0752 | ergothioneine biosynthesis |
| GenProp0753 | mycothiol biosynthesis |
| GenProp0759 | para-aminobenzoic acid (PABA) biosynthesis from chorismate |
| GenProp0791 | coenzyme F420 biosynthesis |
| GenProp0792 | 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis |
| GenProp0836 | menaquinone biosynthesis |
| GenProp0860 | tryptophan tryptophylquinone modification of methylamine dehydrogenase |
| GenProp0862 | pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway |
| GenProp0863 | pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway |
| GenProp0891 | coenzyme M biosynthesis |
| GenProp0917 | mycofactocin system |
| GenProp0927 | bacillithiol biosynthesis |
| GenProp1064 | ovothiol biosynthesis |
| GenProp1096 | coenzyme B biosynthesis |
| GenProp0149 | sulfate reduction to sulfide, assimilatory |
| GenProp0155 | dissimilatory sulfate reduction |
| GenProp0161 | methionine biosynthesis from homoserine |
| GenProp0182 | reduction of oxidized methionine |
| GenProp0191 | sulfate/thiosulfate ABC transporter |
| GenProp0624 | sulfite reductase complex, Salmonella/Clostridium type |
| GenProp0654 | intracellular sulfur oxidation |
| GenProp0729 | methionine salvage from methylthioadenosine |