Genome Property Definition Page
| Accession | GenProp0112 |
| Name | riboflavin, FAD and FMN from GTP and ribulose-5-P |
| Type | PATHWAY |
| Description | Flavin-adenine dinucleotide (FAD) is synthesized via flavinmononucleotide (FMN) and riboflavin (vitamin B2) from GTP, ribulose-5-phosphate and ATP in a 9-step pathway. FAD and FMN are important carriers of hydrogen and electrons which are usually found tightly bound or covalently linked to enzymes such as dehydrogenases, oxidases and monooxygenases. The pathway in bacteria and archaea/fungi vary slightly with the order in which a pair of reductase and deaminase steps take place. |
| JCVI Role | Riboflavin, FMN, and FAD |
| Parent Property | GenProp0184: cofactor biosynthesis |
| Web References | |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| GTP cyclohydrolase II (3.5.4.25) | 1 | YES | TIGR00505 (HMM): GTP cyclohydrolase II PF00925 (HMM): GTP cyclohydrolase II | |
| pyrimidine deaminase (3.5.4.26) | 2 | YES | TIGR00326 (HMM): riboflavin biosynthesis protein RibD TIGR00227 (HMM): riboflavin-specific deaminase C-terminal domain | |
| uracil reductase (1.1.1.193) | 3 | YES | TIGR00326 (HMM): riboflavin biosynthesis protein RibD PF01872 (HMM): riboflavin biosynthesis protein RibD C-terminal domain protein TIGR01508 (HMM): diaminohydroxyphosphoribosylaminopyrimidine reductase | |
| 6,7-dimethyl-8-ribityllumazine synthase | 4 | YES | TIGR00114 (HMM): 6,7-dimethyl-8-ribityllumazine synthase | |
| riboflavin synthase (2.5.1.9) | 5 | YES | TIGR00187 (HMM): riboflavin synthase, alpha subunit | |
| riboflavin kinase (2.7.1.26) | 6--FMN | YES | TIGR00083 (HMM): riboflavin biosynthesis protein RibF | |
| FAD synthetase (2.7.7.2) | 7--FAD | YES | TIGR00083 (HMM): riboflavin biosynthesis protein RibF | |
| 3,4-dihydroxy-2-butanone 4-phosphate synthase | ribB | YES | TIGR00506 (HMM): 3,4-dihydroxy-2-butanone-4-phosphate synthase |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0184 | cofactor biosynthesis |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0001 | chorismate biosynthesis via shikimate |
| GenProp0030 | glutathione biosynthesis |
| GenProp0036 | biotin biosynthesis |
| GenProp0038 | tetrahydrofolate biosynthesis from GTP and PABA |
| GenProp0057 | NAD(P) biosynthesis from L-aspartate and DHAP |
| GenProp0124 | pantothenate biosynthesis from aspartate and 2-oxoisovalerate |
| GenProp0136 | ubiquinone biosynthesis from chorismate, aerobic |
| GenProp0140 | iron-sulfur cluster assembly systems |
| GenProp0170 | coenzyme PQQ biosynthesis |
| GenProp0171 | coenzyme A biosynthesis from pantothenate |
| GenProp0194 | siroheme biosynthesis from uroporphrinogen-III |
| GenProp0220 | uroporhyrinogen III biosynthesis from 5-aminolevulinate |
| GenProp0221 | protoporphyrin IX biosynthesis from uroporphyrinogen III |
| GenProp0222 | protoheme from protoporphyrin IX |
| GenProp0250 | thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly |
| GenProp0255 | 5-aminolevulinate biosynthesis |
| GenProp0261 | thiamin pyrophosphate (TPP) de novo biosynthesis |
| GenProp0274 | coenzyme B12 biosynthesis - overview |
| GenProp0300 | photosynthetic cofactor biosynthesis |
| GenProp0466 | molybdopterin biosynthesis |
| GenProp0752 | ergothioneine biosynthesis |
| GenProp0753 | mycothiol biosynthesis |
| GenProp0759 | para-aminobenzoic acid (PABA) biosynthesis from chorismate |
| GenProp0791 | coenzyme F420 biosynthesis |
| GenProp0792 | 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis |
| GenProp0836 | menaquinone biosynthesis |
| GenProp0860 | tryptophan tryptophylquinone modification of methylamine dehydrogenase |
| GenProp0862 | pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway |
| GenProp0863 | pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway |
| GenProp0891 | coenzyme M biosynthesis |
| GenProp0917 | mycofactocin system |
| GenProp0927 | bacillithiol biosynthesis |
| GenProp1064 | ovothiol biosynthesis |
| GenProp1096 | coenzyme B biosynthesis |