Genome Property Definition Page
Accession | GenProp0127 | |
Name | Tat (Sec-independent) protein export | |
Type | SYSTEM | |
Description | The twin-arginine dependent translocation (Tat) system of protein transport differs from Sec-dependent translocation in that the Tat system transports folded proteins while Sec feeds through unfolded, nascent proteins that fold after they cross the membrane. The significance is that Tat lets cofactors such as flavins or iron-sulfur clusters be retained during transit across the membrane. Targets for the system can often be recognized by a characteristic signal sequence with an Arg-Arg motif. The target proteins usually are predicted to perform redox functions. This property reflects detection of the whole system: components of the translocase and at least one example of a predicted Tat signal sequence. Every system must have at least one TatA homolog (other than TatB) and at least one TatC homolog. TatB occurs only in Proteobacteria and is required at least in E. coli. Recently, several proteins (TorD, NapD) have been shown to act as chaperones that bind the TAT signal peptide of a specific protein and delay translocation until the cofactor has bound. | |
JCVI Role | Protein and peptide secretion and trafficking | |
Parent Property | GenProp0075: protein modification, prosthetic groups and cofactors GenProp0179: protein transport | |
Literature References |
| |
Web References | KEGG: Protein export |
Components
Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
---|---|---|---|---|
TAT signal peptide-binding chaperone | TATchap | NO | PF03927 (HMM): NapD protein PF06192 (HMM): PF02613 (HMM): nitrate reductase delta subunit | |
twin-Arg translocation proteins TatA/E | TatA/E | YES | TIGR01411 (HMM): twin arginine-targeting protein translocase, TatA/E family | |
twin-Arg translocation protein TatB (Proteobacteria) | TatB | NO | TIGR01410 (HMM): twin arginine-targeting protein translocase TatB | |
translocase TatC | TatC | YES | TIGR00945 (HMM): twin arginine-targeting protein translocase TatC TIGR01912 (HMM): Sec-independent protein translocase TatC | |
has twin-arginine signal sequence | example | YES | TIGR01409 (HMM): Tat (twin-arginine translocation) pathway signal sequence |
Parent Properties
Accession | Name |
---|---|
GenProp0075 | protein modification, prosthetic groups and cofactors |
GenProp0179 | protein transport |
Sibling Properties
Accession | Name |
---|---|
GenProp0002 | coenzyme F420 utilization |
GenProp0016 | selenocysteine system |
GenProp0061 | lipoprotein system lgt/lsp/lnt |
GenProp0284 | cobalamin-utilizing enzymes |
GenProp0295 | prokaryotic N-terminal cleavage/methylation, type IV pilin-like |
GenProp0726 | selenium-dependent molybdenum hydroxylase system |
GenProp0745 | lipoyl-protein attachment |
GenProp0860 | tryptophan tryptophylquinone modification of methylamine dehydrogenase |
GenProp0918 | anaerobic sulfatase/maturase system |
GenProp0923 | mycothiol system |
GenProp0933 | bacillithiol utilization |
GenProp0938 | glycine radical enzyme system, YjjI/YjjW pair |
GenProp0943 | pyruvate formate-lyase system |
GenProp0052 | type III secretion |
GenProp0053 | type II secretion |
GenProp0054 | type IV secretion |
GenProp0059 | type I secretion |
GenProp0205 | signal recognition system, bacterial |
GenProp0207 | lipoprotein localization system lolABCDE |
GenProp0209 | Sec system preprotein translocase |
GenProp0326 | protein sorting system, PEP-CTERM/exosortase (generic) |
GenProp0626 | protein sorting system, sortase type, LPXTG/SrtA class |
GenProp0664 | protein sorting system, sortase type, SrtB class |
GenProp0669 | protein sorting system, putative, exosortase G class |
GenProp0735 | type VI secretion |
GenProp0778 | protein sorting system, GlyGly-CTERM/rhombosortase |
GenProp0844 | accessory Sec system for serine-rich glycoprotein transport |
GenProp0845 | protein sorting system, KxYKxGKxW class |
GenProp0847 | exosporium |
GenProp0859 | protein sorting system, proteobacterial dedicated sortase type |
GenProp0904 | type VII secretion, Actinobacteria form |
GenProp0905 | type VII secretion, Firmicutes form |
GenProp0928 | OMP chaperone system: SurA-Skp-DegP |
GenProp0957 | protein sorting system, SipW class |
GenProp0978 | protein sorting system, PGF-CTERM/archaeosortase A |
GenProp0979 | protein sorting system, PEF-CTERM/archaeosortase C |
GenProp0980 | protein sorting system, putative, exosortase F class |
GenProp0983 | protein sorting system, VPXXXP-CTERM/archaeosortase B |
GenProp0985 | protein sorting system, VPDSG-CTERM/exosortase C |
GenProp0986 | protein sorting system, VPLPA-CTERM/exosortase D |
GenProp0987 | protein sorting system, cyano-PEP-CTERM class |
GenProp0989 | protein sorting system, VPEID-CTERM/exosortase E |
GenProp0993 | protein sorting system, PIP-CTERM/archaeosortase D |
GenProp0996 | protein sorting system, IPTLxxWG-CTERM/exosortase H |
GenProp0999 | Por secretion system |
GenProp1005 | protein sorting system, putative, exosortase J class |
GenProp1054 | protein sorting system, MSEP-CTERM/exosortase K |
GenProp1055 | protein sorting system, PEFG-CTERM/thaumarchaeosortase |
GenProp1074 | type V secretion |
GenProp1087 | protein sorting system, vault protein/exosortase N |
GenProp1102 | protein sorting system, CGP-CTERM/unknown of Thermococcaceae |
GenProp1103 | protein sorting system, Synergist-CTERM/unknown of Synergistetes |