Genome Property Definition Page

NameTat (Sec-independent) protein export
DescriptionThe twin-arginine dependent translocation (Tat) system of protein transport differs from Sec-dependent translocation in that the Tat system transports folded proteins while Sec feeds through unfolded, nascent proteins that fold after they cross the membrane. The significance is that Tat lets cofactors such as flavins or iron-sulfur clusters be retained during transit across the membrane. Targets for the system can often be recognized by a characteristic signal sequence with an Arg-Arg motif. The target proteins usually are predicted to perform redox functions. This property reflects detection of the whole system: components of the translocase and at least one example of a predicted Tat signal sequence. Every system must have at least one TatA homolog (other than TatB) and at least one TatC homolog. TatB occurs only in Proteobacteria and is required at least in E. coli. Recently, several proteins (TorD, NapD) have been shown to act as chaperones that bind the TAT signal peptide of a specific protein and delay translocation until the cofactor has bound.
JCVI RoleProtein and peptide secretion and trafficking
Parent PropertyGenProp0075: protein modification, prosthetic groups and cofactors
GenProp0179: protein transport
Literature References
[ 1 ]Dilks K, Rose RW, Hartmann E, Pohlschroder M  Prokaryotic utilization of the twin-arginine translocation pathway: a genomic survey.  J Bacteriol. 2003 Feb;185(4):1478-83.  PMID 12562823
[ 2 ] Maillard J, Spronk CA, Buchanan G, Lyall V, Richardson DJ, Palmer T, Vuister GW, Sargent F   Structural diversity in twin-arginine signal peptide-binding proteins.   Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15641-6. Epub 2007 Sep 27.  PMID 17901208
Web ReferencesKEGG: Protein export

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
TAT signal peptide-binding chaperoneTATchapNOPF03927 (HMM): NapD protein
PF06192 (HMM):
PF02613 (HMM): nitrate reductase delta subunit
twin-Arg translocation proteins TatA/ETatA/EYESTIGR01411 (HMM): twin arginine-targeting protein translocase, TatA/E family
twin-Arg translocation protein TatB (Proteobacteria)TatBNOTIGR01410 (HMM): twin arginine-targeting protein translocase TatB
translocase TatCTatCYESTIGR00945 (HMM): twin arginine-targeting protein translocase TatC
TIGR01912 (HMM): Sec-independent protein translocase TatC
has twin-arginine signal sequenceexampleYESTIGR01409 (HMM): Tat (twin-arginine translocation) pathway signal sequence

Parent Properties
GenProp0075protein modification, prosthetic groups and cofactors
GenProp0179protein transport

Sibling Properties
GenProp0002coenzyme F420 utilization
GenProp0016selenocysteine system
GenProp0061lipoprotein system lgt/lsp/lnt
GenProp0284cobalamin-utilizing enzymes
GenProp0295prokaryotic N-terminal cleavage/methylation, type IV pilin-like
GenProp0726selenium-dependent molybdenum hydroxylase system
GenProp0745lipoyl-protein attachment
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0918anaerobic sulfatase/maturase system
GenProp0923mycothiol system
GenProp0933bacillithiol utilization
GenProp0938glycine radical enzyme system, YjjI/YjjW pair
GenProp0943pyruvate formate-lyase system
GenProp0052type III secretion
GenProp0053type II secretion
GenProp0054type IV secretion
GenProp0059type I secretion
GenProp0205signal recognition system, bacterial
GenProp0207lipoprotein localization system lolABCDE
GenProp0209Sec system preprotein translocase
GenProp0326protein sorting system, PEP-CTERM/exosortase (generic)
GenProp0626protein sorting system, sortase type, LPXTG/SrtA class
GenProp0664protein sorting system, sortase type, SrtB class
GenProp0669protein sorting system, putative, exosortase G class
GenProp0735type VI secretion
GenProp0778protein sorting system, GlyGly-CTERM/rhombosortase
GenProp0844accessory Sec system for serine-rich glycoprotein transport
GenProp0845protein sorting system, KxYKxGKxW class
GenProp0859protein sorting system, proteobacterial dedicated sortase type
GenProp0904type VII secretion, Actinobacteria form
GenProp0905type VII secretion, Firmicutes form
GenProp0928OMP chaperone system: SurA-Skp-DegP
GenProp0957protein sorting system, SipW class
GenProp0978protein sorting system, PGF-CTERM/archaeosortase A
GenProp0979protein sorting system, PEF-CTERM/archaeosortase C
GenProp0980protein sorting system, putative, exosortase F class
GenProp0983protein sorting system, VPXXXP-CTERM/archaeosortase B
GenProp0985protein sorting system, VPDSG-CTERM/exosortase C
GenProp0986protein sorting system, VPLPA-CTERM/exosortase D
GenProp0987protein sorting system, cyano-PEP-CTERM class
GenProp0989protein sorting system, VPEID-CTERM/exosortase E
GenProp0993protein sorting system, PIP-CTERM/archaeosortase D
GenProp0996protein sorting system, IPTLxxWG-CTERM/exosortase H
GenProp0999Por secretion system
GenProp1005protein sorting system, putative, exosortase J class
GenProp1054protein sorting system, MSEP-CTERM/exosortase K
GenProp1055protein sorting system, PEFG-CTERM/thaumarchaeosortase
GenProp1074type V secretion
GenProp1087protein sorting system, vault protein/exosortase N
GenProp1102protein sorting system, CGP-CTERM/unknown of Thermococcaceae
GenProp1103protein sorting system, Synergist-CTERM/unknown of Synergistetes