Genome Property Definition Page

Namemycothiol system
DescriptionMycothiol is a glutathione analog common in the Actinobacteria, but not found elsewhere. This Genome Property provides a higher-level view of mycothiol metabolism that includes its synthesis (GenProp0753), the regeneration of mycothiol from mycothione (its disulfide-bonded dimer) by NADPH-dependent reduction, and a guild of mycothiol-dependent enzymes, the discovery of which is incomplete.
Parent PropertyGenProp0075: protein modification, prosthetic groups and cofactors
Literature References
[ 1 ]Rawat M, Av-Gay Y  Mycothiol-dependent proteins in actinomycetes.  FEMS Microbiol Rev. 2007 Apr;31(3):278-92. Epub 2007 Feb 26.  PMID 17286835
Gene Ontology TermGO:0010126: mycothiol metabolic process (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
anti-sigma-R factor RsrAantisigYESTIGR03988 (HMM): mycothiol system anti-sigma-R factor
mycothione reductasedisulfYESTIGR03452 (HMM): mycothione reductaseGO:0010126: mycothiol metabolic process
mycothiol-dependent enzymemyc_useYESTIGR03446 (HMM): mycothiol conjugate amidase Mca
TIGR03451 (HMM): S-(hydroxymethyl)mycothiol dehydrogenase
GO:0010126: mycothiol metabolic process
mycothiol biosynthesissynthYESGenProp0753 (GENPROP): mycothiol biosynthesis

Parent Properties
GenProp0075protein modification, prosthetic groups and cofactors

Sibling Properties
GenProp0002coenzyme F420 utilization
GenProp0016selenocysteine system
GenProp0061lipoprotein system lgt/lsp/lnt
GenProp0127Tat (Sec-independent) protein export
GenProp0284cobalamin-utilizing enzymes
GenProp0295prokaryotic N-terminal cleavage/methylation, type IV pilin-like
GenProp0726selenium-dependent molybdenum hydroxylase system
GenProp0745lipoyl-protein attachment
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0918anaerobic sulfatase/maturase system
GenProp0933bacillithiol utilization
GenProp0938glycine radical enzyme system, YjjI/YjjW pair
GenProp0943pyruvate formate-lyase system