Genome Property Definition Page
| Accession | GenProp0002 |
| Name | coenzyme F420 utilization |
| Type | GUILD |
| Description | Coenzyme F420 (a 7,8-didemethyl-8-hydroxy 5-deazaflavin) is found in methanogenic archaea, the Mycobacteria, and some other species. Forms differ in the number of glutamyl residues attached. The chromophore by itself, FO, often can replace intact F420, so the literature will occasionally describe an enzyme dependent on FO. This does not necessarily mean the FO is not typically part of coenzyme F420 in vivo. However, it appears that only FO, and not F420, occurs in the Cyanobacteria. This property describes the presence of enzymes that use F420 as an electron donor or receptor, as opposed to enzymes of its biosynthesis. |
| Parent Property | GenProp0075: protein modification, prosthetic groups and cofactors |
| Web References | IUBMB: Methane Biosynthesis IUBMB: Coenzyme F420 hydrogenase |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| LLM-family F420-associated subfamilies | 420_LLM | NO | TIGR03554 (HMM): glucose-6-phosphate dehydrogenase (coenzyme-F420) TIGR03555 (HMM): 5,10-methylenetetrahydromethanopterin reductase TIGR03557 (HMM): F420-dependent oxidoreductase, G6PDH family TIGR03559 (HMM): probable F420-dependent oxidoreductase, Rv3520c family TIGR03560 (HMM): probable F420-dependent oxidoreductase, Rv1855c family TIGR03564 (HMM): F420-dependent oxidoreductase, MSMEG_4879 family TIGR03617 (HMM): probable F420-dependent oxidoreductase, MSMEG_2256 family TIGR03619 (HMM): probable F420-dependent oxidoreductase, Rv2161c family TIGR03620 (HMM): probable F420-dependent oxidoreductase, MSMEG_4141 family TIGR03621 (HMM): probable F420-dependent oxidoreductase, MSMEG_2516 family TIGR03841 (HMM): probable F420-dependent oxidoreductase, Rv3093c family TIGR03842 (HMM): F420-dependent oxidoreductase, CPS_4043 family TIGR03856 (HMM): probable F420-dependent oxidoreductase, MSMEG_2906 family TIGR03854 (HMM): probable F420-dependent oxidoreductase, MSMEG_3544 family TIGR03857 (HMM): probable F420-dependent oxidoreductase, MSMEG_2249 family TIGR04024 (HMM): coenzyme F420-dependent oxidoreductase, NP1902A family | |
| methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase | 420_MTD | NO | PF01993 (HMM): methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase | |
| PPOX-class probable F420-dependent enzyme | 420_POX | NO | TIGR03618 (HMM): PPOX class probable F420-dependent enzyme TIGR03666 (HMM): PPOX class probable F420-dependent enzyme, Rv2061 family TIGR03667 (HMM): PPOX class probable F420-dependent enzyme, Rv3369 family TIGR03668 (HMM): PPOX class probable F420-dependent enzyme, Rv0121 family TIGR04023 (HMM): PPOX class F420-dependent enzyme, MSMEG_5819/OxyR family | |
| PA-824 prodrug activation accessory family | 420_nit | NO | TIGR00026 (HMM): deazaflavin-dependent oxidoreductase, nitroreductase family | |
| F420-associated branch of DUF2342 family | F420_DUF | NO | TIGR03883 (HMM): uncharacterized protein, coenzyme F420 biosynthesis associated | |
| Biosynthesis of F420 | biosynth | YES | GenProp0791 (GENPROP): coenzyme F420 biosynthesis | |
| 5,10-methylenetetrahydromethanopterin reductase | mer | NO | TIGR03555 (HMM): 5,10-methylenetetrahydromethanopterin reductase | |
| hydrogenase, nickel and F420-dependent | nic_hyd | NO | GenProp0723 (GENPROP): hydrogenase, nickel and F420-dependent | |
| NADPH-dependent F420 reductase | npdG | NO | TIGR01915 (HMM): NADPH-dependent F420 reductase |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0075 | protein modification, prosthetic groups and cofactors |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0016 | selenocysteine system |
| GenProp0061 | lipoprotein system lgt/lsp/lnt |
| GenProp0127 | Tat (Sec-independent) protein export |
| GenProp0284 | cobalamin-utilizing enzymes |
| GenProp0295 | prokaryotic N-terminal cleavage/methylation, type IV pilin-like |
| GenProp0726 | selenium-dependent molybdenum hydroxylase system |
| GenProp0745 | lipoyl-protein attachment |
| GenProp0860 | tryptophan tryptophylquinone modification of methylamine dehydrogenase |
| GenProp0918 | anaerobic sulfatase/maturase system |
| GenProp0923 | mycothiol system |
| GenProp0933 | bacillithiol utilization |
| GenProp0938 | glycine radical enzyme system, YjjI/YjjW pair |
| GenProp0943 | pyruvate formate-lyase system |