Genome Property Definition Page

Namecoenzyme F420 utilization
DescriptionCoenzyme F420 (a 7,8-didemethyl-8-hydroxy 5-deazaflavin) is found in methanogenic archaea, the Mycobacteria, and some other species. Forms differ in the number of glutamyl residues attached. The chromophore by itself, FO, often can replace intact F420, so the literature will occasionally describe an enzyme dependent on FO. This does not necessarily mean the FO is not typically part of coenzyme F420 in vivo. However, it appears that only FO, and not F420, occurs in the Cyanobacteria. This property describes the presence of enzymes that use F420 as an electron donor or receptor, as opposed to enzymes of its biosynthesis.
Parent PropertyGenProp0075: protein modification, prosthetic groups and cofactors
Web ReferencesIUBMB: Methane Biosynthesis
IUBMB: Coenzyme F420 hydrogenase

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
LLM-family F420-associated subfamilies420_LLMNOTIGR03554 (HMM): glucose-6-phosphate dehydrogenase (coenzyme-F420)
TIGR03555 (HMM): 5,10-methylenetetrahydromethanopterin reductase
TIGR03557 (HMM): F420-dependent oxidoreductase, G6PDH family
TIGR03559 (HMM): probable F420-dependent oxidoreductase, Rv3520c family
TIGR03560 (HMM): probable F420-dependent oxidoreductase, Rv1855c family
TIGR03564 (HMM): F420-dependent oxidoreductase, MSMEG_4879 family
TIGR03617 (HMM): probable F420-dependent oxidoreductase, MSMEG_2256 family
TIGR03619 (HMM): probable F420-dependent oxidoreductase, Rv2161c family
TIGR03620 (HMM): probable F420-dependent oxidoreductase, MSMEG_4141 family
TIGR03621 (HMM): probable F420-dependent oxidoreductase, MSMEG_2516 family
TIGR03841 (HMM): probable F420-dependent oxidoreductase, Rv3093c family
TIGR03842 (HMM): F420-dependent oxidoreductase, CPS_4043 family
TIGR03856 (HMM): probable F420-dependent oxidoreductase, MSMEG_2906 family
TIGR03854 (HMM): probable F420-dependent oxidoreductase, MSMEG_3544 family
TIGR03857 (HMM): probable F420-dependent oxidoreductase, MSMEG_2249 family
TIGR04024 (HMM): coenzyme F420-dependent oxidoreductase, NP1902A family
methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase420_MTDNOPF01993 (HMM): methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase
PPOX-class probable F420-dependent enzyme420_POXNOTIGR03618 (HMM): PPOX class probable F420-dependent enzyme
TIGR03666 (HMM): PPOX class probable F420-dependent enzyme, Rv2061 family
TIGR03667 (HMM): PPOX class probable F420-dependent enzyme, Rv3369 family
TIGR03668 (HMM): PPOX class probable F420-dependent enzyme, Rv0121 family
TIGR04023 (HMM): PPOX class F420-dependent enzyme, MSMEG_5819/OxyR family
PA-824 prodrug activation accessory family420_nitNOTIGR00026 (HMM): deazaflavin-dependent oxidoreductase, nitroreductase family
F420-associated branch of DUF2342 familyF420_DUFNOTIGR03883 (HMM): uncharacterized protein, coenzyme F420 biosynthesis associated
Biosynthesis of F420biosynthYESGenProp0791 (GENPROP): coenzyme F420 biosynthesis
5,10-methylenetetrahydromethanopterin reductasemerNOTIGR03555 (HMM): 5,10-methylenetetrahydromethanopterin reductase
hydrogenase, nickel and F420-dependentnic_hydNOGenProp0723 (GENPROP): hydrogenase, nickel and F420-dependent
NADPH-dependent F420 reductasenpdGNOTIGR01915 (HMM): NADPH-dependent F420 reductase

Parent Properties
GenProp0075protein modification, prosthetic groups and cofactors

Sibling Properties
GenProp0016selenocysteine system
GenProp0061lipoprotein system lgt/lsp/lnt
GenProp0127Tat (Sec-independent) protein export
GenProp0284cobalamin-utilizing enzymes
GenProp0295prokaryotic N-terminal cleavage/methylation, type IV pilin-like
GenProp0726selenium-dependent molybdenum hydroxylase system
GenProp0745lipoyl-protein attachment
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0918anaerobic sulfatase/maturase system
GenProp0923mycothiol system
GenProp0933bacillithiol utilization
GenProp0938glycine radical enzyme system, YjjI/YjjW pair
GenProp0943pyruvate formate-lyase system