Genome Property Definition Page

Nameselenium-dependent molybdenum hydroxylase system
DescriptionThe enzyme selenide,water dikinase (SelD) activates selenium for use in bacteria as selenocysteine to be incorporated during protein translation or as the modified base selenouridine in certain tRNAs. However, SelD occurs in some genomes with neither of those traits, and instead acts in the post-translational addition of a labile selenium to a molybdenum-containing cofactor. A bioinformatic analysis showed that the family of TIGRFAMs model TIGR03309 represents a third selenium-dependent bacterial trait, and that it is quite widespread. The current version of this Genome Property includes both selenium cofactor maturation proteins and subunits of predicted labile selenium cofactor enzymes.
Parent PropertyGenProp0075: protein modification, prosthetic groups and cofactors
Literature References
[ 1 ]Self WT, Stadtman TC  Selenium-dependent metabolism of purines: A selenium-dependent purine hydroxylase and xanthine dehydrogenase were purified from Clostridium purinolyticum and characterized.  Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7208-13.  PMID 10860985
[ 2 ]Self WT, Wolfe MD, Stadtman TC  Cofactor determination and spectroscopic characterization of the selenium-dependent purine hydroxylase from Clostridium purinolyticum.  Biochemistry. 2003 Sep 30;42(38):11382-90.  PMID 14503889
[ 3 ]Dobbek H, Gremer L, Meyer O, Huber R  Crystal structure and mechanism of CO dehydrogenase, a molybdo iron-sulfur flavoprotein containing S-selanylcysteine.  Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8884-9.  PMID 10430865
[ 4 ]Srivastava M, Mallard C, Barke T, Hancock LE, Self WT  A selenium-dependent xanthine dehydrogenase triggers biofilm proliferation in Enterococcus faecalis through oxidant production.  J Bacteriol. 2011 Apr;193(7):1643-52.  PMID 21257770

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
diaminopropionate ammonia-lyase23_DAPNOTIGR03528 (HMM): diaminopropionate ammonia-lyase
selenium-dependent molybdenum hydroxylase, protein 1Se_AAYESTIGR03309 (HMM): selenium-dependent molybdenum hydroxylase system protein, YqeB family
selenium-dependent molybdenum hydroxylase, protein 3Se_CCYESTIGR03172 (HMM): putative selenium-dependent hydroxylase accessory protein YqeC
molybdenum cofactor cytidylyltransferaseSe_MocAYESTIGR03310 (HMM): molybdenum cofactor cytidylyltransferase
selenide, water dikinaseSe_SelDNOTIGR00476 (HMM): selenide, water dikinase
selenium metabolism protein YedFSe_YedFNOTIGR03527 (HMM): selenium metabolism protein YedF
selenium-dependent xanthine dehydrogenaseSe_enz1NOTIGR03311 (HMM): selenium-dependent xanthine dehydrogenase
probable selenate reductase, FAD-binding subunitSe_enz2NOTIGR03312 (HMM): probable selenate reductase, FAD-binding subunit
probable selenate reductase, molybdenum subunitSe_enz3NOTIGR03313 (HMM): probable selenate reductase, molybdenum-binding subunit
probable selenate reductase, YgfK subunitSe_enz4NOTIGR03315 (HMM): putative selenate reductase, YgfK subunit
putative selenium metabolism hydrolaseSe_protNOTIGR03526 (HMM): putative selenium metabolism hydrolase

Parent Properties
GenProp0075protein modification, prosthetic groups and cofactors

Sibling Properties
GenProp0002coenzyme F420 utilization
GenProp0016selenocysteine system
GenProp0061lipoprotein system lgt/lsp/lnt
GenProp0127Tat (Sec-independent) protein export
GenProp0284cobalamin-utilizing enzymes
GenProp0295prokaryotic N-terminal cleavage/methylation, type IV pilin-like
GenProp0745lipoyl-protein attachment
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0918anaerobic sulfatase/maturase system
GenProp0923mycothiol system
GenProp0933bacillithiol utilization
GenProp0938glycine radical enzyme system, YjjI/YjjW pair
GenProp0943pyruvate formate-lyase system