Genome Property Definition Page
| Accession | GenProp0199 |
| Name | lysine biosynthesis |
| Type | METAPATH |
| Description | The basic amino acid lysine may be synthesized by one of two types of pathways pathways in prokaryotes, the diaminopimelate (DAP) pathways and the alpha-aminoadipate (AAA) pathway. The DAP pathway has several variants including the dehydrogenase (reductive) pathway which requires ammonia and NADPH and the acetylated and succinylated pathways which do not. A non-reductive pathway which uses neither acetate or succinate protecting groups is found in plants but has not been observed in prokaryotes. The AAA pathway has a variant found in fungi and plants which has not been observed in prokaryotes. |
| JCVI Role | Aspartate family |
| Parent Property | GenProp0126: amino acid biosynthesis |
| Web References | Lysine biosynthesis I:MetaCyc Lysine biosynthesis II:MetaCyc Lysine biosynthesis IV:MetaCyc Lysine biosynthesis III:MetaCyc Lysine biosynthesis:KEGG |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| lysine biosynthesis pathways | 1 | YES | GenProp0125 (GENPROP): lysine biosynthesis via diaminopimelate (DAP) GenProp0193 (GENPROP): lysine biosynthesis via alpha-aminoadipate (AAA pathway) GenProp0788 (GENPROP): lysine biosynthesis via diaminopimelate (DAP) utilizing ammonia and NADPH |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0126 | amino acid biosynthesis |
Child Properties
| Accession | Name |
|---|---|
| GenProp0125 | lysine biosynthesis via diaminopimelate (DAP) |
| GenProp0193 | lysine biosynthesis via alpha-aminoadipate (AAA pathway) |
| GenProp0788 | lysine biosynthesis via diaminopimelate (DAP) utilizing ammonia and NADPH |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0001 | chorismate biosynthesis via shikimate |
| GenProp0016 | selenocysteine system |
| GenProp0037 | tryptophan biosynthesis from ribose-5-phosphate |
| GenProp0039 | phenylalanine biosynthesis from chorismate |
| GenProp0045 | tyrosine biosynthesis from chorismate |
| GenProp0087 | arginine biosynthesis from glutatmate via N-acetylglutamate |
| GenProp0109 | histidine biosynthesis from ribose-5-phosphate |
| GenProp0111 | proline biosynthesis from glutamate |
| GenProp0117 | arginine biosynthesis from ornithine, carbamoyl-p and aspartate |
| GenProp0118 | ornithine biosynthesis from glutamate, acetylated branch |
| GenProp0159 | threonine biosynthesis from aspartate semialdehyde |
| GenProp0160 | aspartate semialdehyde biosynthesis from aspartate |
| GenProp0161 | methionine biosynthesis from homoserine |
| GenProp0162 | isoleucine biosynthesis from threonine and pyruvate |
| GenProp0163 | valine biosynthesis from pyruvate |
| GenProp0164 | leucine biosynthesis from pyruvate and acetyl-CoA |
| GenProp0178 | glycine cleavage system |
| GenProp0304 | cysteine biosynthesis, tRNA-dependent |
| GenProp0305 | cysteine biosynthesis |
| GenProp0729 | methionine salvage from methylthioadenosine |
| GenProp0797 | selenocysteinyl-tRNA, PSTK/SepSecS pathway |