Genome Property Definition Page
| Accession | GenProp0039 |
| Name | phenylalanine biosynthesis from chorismate |
| Type | PATHWAY |
| Description | The aromatic amino acid phenylalanine is synthesized via a three step pathway from chorismate. The first two steps, isomerization of chorismate to prephenate and dehydration of prephenate to phenylpyruvate are modelled by specific HMMs. The third step, transamination of phenylpyruvate to form phenylalanine has not been ascribed to a specific transaminase in non-mammals. The YES state for this pathway is therefore indicative of the presence of the two characterized steps. |
| JCVI Role | Aromatic amino acid family |
| Parent Property | GenProp0126: amino acid biosynthesis |
| Web References | KEGG: Phenylalanine Metabolism IUBMB: Phenylalanine and Tyrosine Biosynthesis |
| Gene Ontology Term | GO:0009094: L-phenylalanine biosynthetic process (biological_process) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| chorismate mutase | 1 | YES | TIGR01791 (HMM): chorismate mutase TIGR01795 (HMM): chorismate mutase TIGR01796 (HMM): chorismate mutase TIGR01797 (HMM): chorismate mutase TIGR01799 (HMM): chorismate mutase TIGR01801 (HMM): chorismate mutase TIGR01802 (HMM): chorismate mutase TIGR01805 (HMM): chorismate mutase TIGR01806 (HMM): putative chorismate mutase TIGR01807 (HMM): chorismate mutase TIGR01808 (HMM): chorismate mutase | GO:0009094: L-phenylalanine biosynthetic process GO:0009094: L-phenylalanine biosynthetic process GO:0009094: L-phenylalanine biosynthetic process GO:0009094: L-phenylalanine biosynthetic process GO:0009094: L-phenylalanine biosynthetic process GO:0009094: L-phenylalanine biosynthetic process GO:0009094: L-phenylalanine biosynthetic process GO:0009094: L-phenylalanine biosynthetic process GO:0009094: L-phenylalanine biosynthetic process GO:0009094: L-phenylalanine biosynthetic process |
| prephenate dehydratase | 2 | YES | PF00800 (HMM): prephenate dehydratase | GO:0009094: L-phenylalanine biosynthetic process |
| a transaminase | 3 | NO | PF00155 (HMM-CLUST): aminotransferase, class I/II | GO:0009094: L-phenylalanine biosynthetic process |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0126 | amino acid biosynthesis |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0001 | chorismate biosynthesis via shikimate |
| GenProp0016 | selenocysteine system |
| GenProp0037 | tryptophan biosynthesis from ribose-5-phosphate |
| GenProp0045 | tyrosine biosynthesis from chorismate |
| GenProp0087 | arginine biosynthesis from glutatmate via N-acetylglutamate |
| GenProp0109 | histidine biosynthesis from ribose-5-phosphate |
| GenProp0111 | proline biosynthesis from glutamate |
| GenProp0117 | arginine biosynthesis from ornithine, carbamoyl-p and aspartate |
| GenProp0118 | ornithine biosynthesis from glutamate, acetylated branch |
| GenProp0159 | threonine biosynthesis from aspartate semialdehyde |
| GenProp0160 | aspartate semialdehyde biosynthesis from aspartate |
| GenProp0161 | methionine biosynthesis from homoserine |
| GenProp0162 | isoleucine biosynthesis from threonine and pyruvate |
| GenProp0163 | valine biosynthesis from pyruvate |
| GenProp0164 | leucine biosynthesis from pyruvate and acetyl-CoA |
| GenProp0178 | glycine cleavage system |
| GenProp0199 | lysine biosynthesis |
| GenProp0304 | cysteine biosynthesis, tRNA-dependent |
| GenProp0305 | cysteine biosynthesis |
| GenProp0729 | methionine salvage from methylthioadenosine |
| GenProp0797 | selenocysteinyl-tRNA, PSTK/SepSecS pathway |