Genome Property Definition Page

AccessionGenProp0161
Namemethionine biosynthesis from homoserine
TypePATHWAY
DescriptionHomoserine (which is also threonine precursor) may be succinylated or acetylated in the first step of methionine biosynthesis in bacteria. The second step removes the acyl group but adds sulfur from cysteine to form cystathionine. Cystathione beta-lyase cleaves cystathionine to produce homocysteine, which is methylated to form methionine.
JCVI RoleAspartate family
Parent PropertyGenProp0126: amino acid biosynthesis
GenProp0196: sulfur metabolism
Gene Ontology TermGO:0019279: L-methionine biosynthetic process from L-homoserine via cystathionine (biological_process)
GO:0019280: L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine (biological_process)
GO:0019281: L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go TermsBranch
O-acetylhomoserine (thiol)-lyaseAcSulfNOTIGR01326 (HMM): O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase1
methylation of homocysteine (various)lastYESTIGR01371 (HMM): 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
TIGR02082 (HMM): methionine synthase
1
homoserine O-succinyltransferasemetAYESTIGR01001 (HMM): homoserine O-succinyltransferasesuccinyl
cystathione gamma-synthase, acetyl branchmetB_acYESdirect assertion (MANUAL)
acet
cystathione gamma-synthase, succinyl branchmetB_sucYESTIGR02080 (HMM): O-succinylhomoserine (thiol)-lyasesuccinyl
cystathionine beta-lyasemetCYESTIGR01324 (HMM): cystathionine beta-lyase
TIGR01329 (HMM): cystathionine beta-lyase
1
5,10-methyleneTHF reductasemetFNOTIGR00676 (HMM): methylenetetrahydrofolate reductase [NAD(P)H]1
methionine biosynthesis protein MetWmetWNOTIGR02081 (HMM): methionine biosynthesis protein MetWsuccinyl
homoserine O-acetyltransferasemetXYESTIGR01392 (HMM): homoserine O-acetyltransferaseacet
O-succinylhomoserine sulfhydrylasemetZNOTIGR01325 (HMM): O-succinylhomoserine sulfhydrylase1

Parent Properties
AccessionName
GenProp0126amino acid biosynthesis
GenProp0196sulfur metabolism


Sibling Properties
AccessionName
GenProp0001chorismate biosynthesis via shikimate
GenProp0016selenocysteine system
GenProp0037tryptophan biosynthesis from ribose-5-phosphate
GenProp0039phenylalanine biosynthesis from chorismate
GenProp0045tyrosine biosynthesis from chorismate
GenProp0087arginine biosynthesis from glutatmate via N-acetylglutamate
GenProp0109histidine biosynthesis from ribose-5-phosphate
GenProp0111proline biosynthesis from glutamate
GenProp0117arginine biosynthesis from ornithine, carbamoyl-p and aspartate
GenProp0118ornithine biosynthesis from glutamate, acetylated branch
GenProp0159threonine biosynthesis from aspartate semialdehyde
GenProp0160aspartate semialdehyde biosynthesis from aspartate
GenProp0162isoleucine biosynthesis from threonine and pyruvate
GenProp0163valine biosynthesis from pyruvate
GenProp0164leucine biosynthesis from pyruvate and acetyl-CoA
GenProp0178glycine cleavage system
GenProp0199lysine biosynthesis
GenProp0304cysteine biosynthesis, tRNA-dependent
GenProp0305cysteine biosynthesis
GenProp0729methionine salvage from methylthioadenosine
GenProp0797selenocysteinyl-tRNA, PSTK/SepSecS pathway
GenProp0030glutathione biosynthesis
GenProp0036biotin biosynthesis
GenProp0140iron-sulfur cluster assembly systems
GenProp0149sulfate reduction to sulfide, assimilatory
GenProp0155dissimilatory sulfate reduction
GenProp0182reduction of oxidized methionine
GenProp0191sulfate/thiosulfate ABC transporter
GenProp0624sulfite reductase complex, Salmonella/Clostridium type
GenProp0654intracellular sulfur oxidation