Genome Property Definition Page

Nametryptophan biosynthesis from ribose-5-phosphate
DescriptionThe essential amino acid tryptophan is synthesized in prokaryotes, plants, and fungi via a conserved six step pathway from the branchpoint compound chrosimate, a common precursor in the biosynthesis of aromatic amino acids [1]. Seven catalytic domains and two alpha/beta subunit complexes comprise this pathway. Individually expressed in some organisms, gene fusions encoding single proteins possessing two or more of these catalytic domains have been observed for every trp gene. Although the occurance of gene fusions have been shown to be phylogenetically unrelated, a conserved gene order can be discerned within the domain Bacteria. Occasionally gene(s) dissociations disrupt gene order as in Campylobacter jejuni and Deinococcus radiodurans, or the pathway is found split between two separate chromosomes as in Rhodobacter sphaeroides. In cyanobacteria, such as Nostoc and Anabaena, it is not uncommon to observe paralogous trp genes as part of a larger "supraoperon" including other aromatic amino acid synthesizing genes as well as their trp counterparts [2].
JCVI RoleAromatic amino acid family
Parent PropertyGenProp0126: amino acid biosynthesis
Literature References
[ 2 ]Xie G, Keyhani NO, Bonner CA, Jensen RA.  Ancient origin of the tryptophan operon and the dynamics of evolutionary change.  Microbiol Mol Biol Rev. 2003 Sep;67(3):303-42  PMID 12966138
Web ReferencesKEGG: Tryptophan metabolism
IUBMB: Tryptophan Biosynthesis
Gene Ontology TermGO:0000162: tryptophan biosynthetic process (biological_process)
GO:0000162: tryptophan biosynthetic process (biological_process)
GO:0006355: regulation of transcription, DNA-dependent (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
ribose-phosphate pyrophosphokinaseYESTIGR01251 (HMM): ribose-phosphate diphosphokinaseGO:0000162: tryptophan biosynthetic process
anthranilate synthase component I1AYESTIGR00564 (HMM): anthranilate synthase component I
TIGR00565 (HMM): anthranilate synthase component I
TIGR01815 (HMM): anthranilate synthase
TIGR01820 (HMM): anthranilate synthase component I
GO:0000162: tryptophan biosynthetic process
GO:0000162: tryptophan biosynthetic process
GO:0000162: tryptophan biosynthetic process
GO:0000162: tryptophan biosynthetic process
anthranilate synthase component II1BYESTIGR00566 (HMM): glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthaseGO:0000162: tryptophan biosynthetic process
anthranilate phosphoribosyltransferase2YESTIGR01245 (HMM): anthranilate phosphoribosyltransferaseGO:0000162: tryptophan biosynthetic process
N-(5'phosphoribosyl)anthranilate isomerase3YESPF00697 (HMM): N-(5'phosphoribosyl)anthranilate isomerase
TIGR01919 (HMM): bifunctional HisA/TrpF protein
GO:0000162: tryptophan biosynthetic process
GO:0000162: tryptophan biosynthetic process
indole-3-glycerol phosphate synthase4YESPF00218 (HMM): indole-3-glycerol phosphate synthaseGO:0000162: tryptophan biosynthetic process
tryptophan synthase, alpha subunit5YESTIGR00262 (HMM): tryptophan synthase, alpha subunitGO:0000162: tryptophan biosynthetic process
tryptophan synthase, beta subunit6YESTIGR00263 (HMM): tryptophan synthase, beta subunit
TIGR01415 (HMM): pyridoxal-phosphate dependent TrpB-like enzyme
GO:0000162: tryptophan biosynthetic process
trp operon repressorrepresNOTIGR01321 (HMM): trp operon repressorGO:0006355: regulation of transcription, DNA-dependent
GO:0000162: tryptophan biosynthetic process

Parent Properties
GenProp0126amino acid biosynthesis

Sibling Properties
GenProp0001chorismate biosynthesis via shikimate
GenProp0016selenocysteine system
GenProp0039phenylalanine biosynthesis from chorismate
GenProp0045tyrosine biosynthesis from chorismate
GenProp0087arginine biosynthesis from glutatmate via N-acetylglutamate
GenProp0109histidine biosynthesis from ribose-5-phosphate
GenProp0111proline biosynthesis from glutamate
GenProp0117arginine biosynthesis from ornithine, carbamoyl-p and aspartate
GenProp0118ornithine biosynthesis from glutamate, acetylated branch
GenProp0159threonine biosynthesis from aspartate semialdehyde
GenProp0160aspartate semialdehyde biosynthesis from aspartate
GenProp0161methionine biosynthesis from homoserine
GenProp0162isoleucine biosynthesis from threonine and pyruvate
GenProp0163valine biosynthesis from pyruvate
GenProp0164leucine biosynthesis from pyruvate and acetyl-CoA
GenProp0178glycine cleavage system
GenProp0199lysine biosynthesis
GenProp0304cysteine biosynthesis, tRNA-dependent
GenProp0305cysteine biosynthesis
GenProp0729methionine salvage from methylthioadenosine
GenProp0797selenocysteinyl-tRNA, PSTK/SepSecS pathway