Genome Property Definition Page

Nameaspartate semialdehyde biosynthesis from aspartate
DescriptionThe aspartate semialdehyde biosynthesis is a two step pathway. [2] The product of this pathway can be used in the lysine biosynthesis or in the pathway leading to homoserine involved in the threonine, isoleucine and methionine biosynthesis. There are three different isozymes differed in their sensitivity to regulation by Lys, Met and Thr in Escherichia coli. [1]
JCVI RoleAspartate family
Parent PropertyGenProp0126: amino acid biosynthesis
Literature References
[ 1 ]Rafalski JA, Falco SC.  Structure of the yeast HOM3 gene which encodes aspartokinase.  J Biol Chem. 1988 Feb 15;263(5):2146-51.  PMID 2892836
Web ReferencesKEGG: Glycine, serine and threonine metabolism
MetaCyc Pathway: homoserine biosynthesis
Gene Ontology TermGO:0009090: homoserine biosynthetic process (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
aspartate kinaseasp_kinYESTIGR00656 (HMM): aspartate kinase, monofunctional class
TIGR00657 (HMM): aspartate kinase
TIGR02078 (HMM): putative Pyrococcus aspartate kinase subunit
GO:0009090: homoserine biosynthetic process
GO:0009090: homoserine biosynthetic process
GO:0009090: homoserine biosynthetic process
aspartate-semialdehyde dehydrogenaseasp_smDHYESTIGR00978 (HMM): aspartate-semialdehyde dehydrogenase
TIGR01296 (HMM): aspartate-semialdehyde dehydrogenase
TIGR01745 (HMM): aspartate-semialdehyde dehydrogenase
GO:0009090: homoserine biosynthetic process
GO:0009090: homoserine biosynthetic process
GO:0009090: homoserine biosynthetic process

Parent Properties
GenProp0126amino acid biosynthesis

Sibling Properties
GenProp0001chorismate biosynthesis via shikimate
GenProp0016selenocysteine system
GenProp0037tryptophan biosynthesis from ribose-5-phosphate
GenProp0039phenylalanine biosynthesis from chorismate
GenProp0045tyrosine biosynthesis from chorismate
GenProp0087arginine biosynthesis from glutatmate via N-acetylglutamate
GenProp0109histidine biosynthesis from ribose-5-phosphate
GenProp0111proline biosynthesis from glutamate
GenProp0117arginine biosynthesis from ornithine, carbamoyl-p and aspartate
GenProp0118ornithine biosynthesis from glutamate, acetylated branch
GenProp0159threonine biosynthesis from aspartate semialdehyde
GenProp0161methionine biosynthesis from homoserine
GenProp0162isoleucine biosynthesis from threonine and pyruvate
GenProp0163valine biosynthesis from pyruvate
GenProp0164leucine biosynthesis from pyruvate and acetyl-CoA
GenProp0178glycine cleavage system
GenProp0199lysine biosynthesis
GenProp0304cysteine biosynthesis, tRNA-dependent
GenProp0305cysteine biosynthesis
GenProp0729methionine salvage from methylthioadenosine
GenProp0797selenocysteinyl-tRNA, PSTK/SepSecS pathway