Genome Property Definition Page

Nametyrosine biosynthesis from chorismate
DescriptionIn prokayotes, the aromatic amino acid tyrosine is synthesized via a three step pathway from chorismate [1]. Presence of the first two reaction steps, isomerization of chorismate to prephenate and dehydrogenation of prephenate to 4-hydroxyphenylpyruvate, reflects tyrosine biosynthesis by this property. The third reaction step, transamination of 4-hydroxyphenylpyruvate to form tyrosine, has not been ascribed to a specific transaminase. In mammals, tyrosine is formed from the tetrahydrobiopterin-dependent oxidation of phenylalanine and is not included in this property.
JCVI RoleAromatic amino acid family
Parent PropertyGenProp0126: amino acid biosynthesis
Web ReferencesKEGG: Tyrosine metabolism
IUBMB: Phenylalanine and Tyrosine Biosynthesis
Gene Ontology TermGO:0006571: tyrosine biosynthetic process (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go TermsBranch
chorismate mutase1YESTIGR01791 (HMM): chorismate mutase
TIGR01795 (HMM): chorismate mutase
TIGR01796 (HMM): chorismate mutase
TIGR01797 (HMM): chorismate mutase
TIGR01799 (HMM): chorismate mutase
TIGR01801 (HMM): chorismate mutase
TIGR01802 (HMM): chorismate mutase
TIGR01805 (HMM): chorismate mutase
TIGR01806 (HMM): putative chorismate mutase
TIGR01807 (HMM): chorismate mutase
TIGR01808 (HMM): chorismate mutase
prephenate dehydrogenase2YESPF02153 (HMM): prephenate dehydrogenasevia4HPP
prephenate dehydratase2aYESPF00800 (HMM): prephenate dehydrataseviaPhe
a transaminase3NO1
phenylalanine-4-hydroxylase4aYESTIGR01267 (HMM): phenylalanine-4-hydroxylaseviaPhe

Parent Properties
GenProp0126amino acid biosynthesis

Sibling Properties
GenProp0001chorismate biosynthesis via shikimate
GenProp0016selenocysteine system
GenProp0037tryptophan biosynthesis from ribose-5-phosphate
GenProp0039phenylalanine biosynthesis from chorismate
GenProp0087arginine biosynthesis from glutatmate via N-acetylglutamate
GenProp0109histidine biosynthesis from ribose-5-phosphate
GenProp0111proline biosynthesis from glutamate
GenProp0117arginine biosynthesis from ornithine, carbamoyl-p and aspartate
GenProp0118ornithine biosynthesis from glutamate, acetylated branch
GenProp0159threonine biosynthesis from aspartate semialdehyde
GenProp0160aspartate semialdehyde biosynthesis from aspartate
GenProp0161methionine biosynthesis from homoserine
GenProp0162isoleucine biosynthesis from threonine and pyruvate
GenProp0163valine biosynthesis from pyruvate
GenProp0164leucine biosynthesis from pyruvate and acetyl-CoA
GenProp0178glycine cleavage system
GenProp0199lysine biosynthesis
GenProp0304cysteine biosynthesis, tRNA-dependent
GenProp0305cysteine biosynthesis
GenProp0729methionine salvage from methylthioadenosine
GenProp0797selenocysteinyl-tRNA, PSTK/SepSecS pathway