Genome Property Definition Page

Namearginine biosynthesis from ornithine, carbamoyl-p and aspartate
DescriptionThe arginine biosynthesis pathway is a three step process and a part of the urea cycle.[2] The first enzyme, ornithine carbamoyltransferases (OTCase) carries out the reaction anabolically in arginine biosynthesis, but in some cases, it carries out catabolic reactions. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily.[1] The third step of the pathway yields L-arginine by argininosuccinate lyase, and the amino acid can be cleaved by arginase, yielding urea and reconstituting ornithine. L-arginine also can be utilized in the creatine biosynthesis.
JCVI RoleGlutamate family
Parent PropertyGenProp0126: amino acid biosynthesis
Literature References
[ 1 ] Villeret V, Clantin B, Tricot C, Legrain C, Roovers M, Stalon V, Glansdorff N, Van Beeumen J.  The crystal structure of Pyrococcus furiosus ornithine carbamoyltransferase reveals a key role for oligomerization in enzyme stability at extremely high temperatures.  Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2801-6.  PMID 9501170
Web ReferencesKEGG: Arginine and proline metabolism
IUBMB: Urea Cycle and Arginine Biosynthesis
Gene Ontology TermGO:0042450: arginine biosynthetic process via ornithine (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
ornithine carbamoyltransferase1YESTIGR00658 (HMM): ornithine carbamoyltransferaseGO:0042450: arginine biosynthetic process via ornithine
argininosuccinate synthase2YESTIGR00032 (HMM): argininosuccinate synthaseGO:0042450: arginine biosynthetic process via ornithine
argininosuccinate lyase3YESTIGR00838 (HMM): argininosuccinate lyaseGO:0042450: arginine biosynthetic process via ornithine

Parent Properties
GenProp0126amino acid biosynthesis

Sibling Properties
GenProp0001chorismate biosynthesis via shikimate
GenProp0016selenocysteine system
GenProp0037tryptophan biosynthesis from ribose-5-phosphate
GenProp0039phenylalanine biosynthesis from chorismate
GenProp0045tyrosine biosynthesis from chorismate
GenProp0087arginine biosynthesis from glutatmate via N-acetylglutamate
GenProp0109histidine biosynthesis from ribose-5-phosphate
GenProp0111proline biosynthesis from glutamate
GenProp0118ornithine biosynthesis from glutamate, acetylated branch
GenProp0159threonine biosynthesis from aspartate semialdehyde
GenProp0160aspartate semialdehyde biosynthesis from aspartate
GenProp0161methionine biosynthesis from homoserine
GenProp0162isoleucine biosynthesis from threonine and pyruvate
GenProp0163valine biosynthesis from pyruvate
GenProp0164leucine biosynthesis from pyruvate and acetyl-CoA
GenProp0178glycine cleavage system
GenProp0199lysine biosynthesis
GenProp0304cysteine biosynthesis, tRNA-dependent
GenProp0305cysteine biosynthesis
GenProp0729methionine salvage from methylthioadenosine
GenProp0797selenocysteinyl-tRNA, PSTK/SepSecS pathway