| Accession | GenProp0117 |
| Name | arginine biosynthesis from ornithine, carbamoyl-p and aspartate |
| Type | PATHWAY |
| Description | The arginine biosynthesis pathway is a three step process and a part of the urea cycle.[2] The first enzyme, ornithine carbamoyltransferases (OTCase) carries out the reaction anabolically in arginine biosynthesis, but in some cases, it carries out catabolic reactions. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily.[1] The third step of the pathway yields L-arginine by argininosuccinate lyase, and the amino acid can be cleaved by arginase, yielding urea and reconstituting ornithine. L-arginine also can be utilized in the creatine biosynthesis. |
| JCVI Role | Glutamate family |
| Parent Property | GenProp0126: amino acid biosynthesis
|
| Literature References | [ 1 ] Villeret V, Clantin B, Tricot C, Legrain C, Roovers M, Stalon V, Glansdorff N, Van Beeumen J. The crystal structure of Pyrococcus furiosus ornithine carbamoyltransferase reveals a key role for oligomerization in enzyme stability at extremely high temperatures. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2801-6. PMID 9501170
|
|
| Web References | KEGG: Arginine and proline metabolism
IUBMB: Urea Cycle and Arginine Biosynthesis
|
| Gene Ontology Term | GO:0042450: arginine biosynthetic process via ornithine (biological_process)
|
