Genome Property Definition Page
| Accession | GenProp0304 | |
| Name | cysteine biosynthesis, tRNA-dependent | |
| Type | PATHWAY | |
| Description | Methanocaldococcus jannaschii is a model archaeal species that lacks a direct cys--tRNA ligase. In a system analogous to pyrrolysine and (in many species) asparagine tRNA aminoacylation, the tRNA is misacylated and then the attached amino acid is modified. This two-step pathway is conducted by proteins in the families of MJ1660 (sepS) and MJ1678 (pscS). This pathway assumes 0-phosphoserine, whose biosynthesis is proposed to require D-3-phosphoglycerate dehydrogenase (TIGR01327) and an unidentified aminotransferase. | |
| JCVI Role | tRNA aminoacylation | |
| Parent Property | GenProp0126: amino acid biosynthesis GenProp0197: protein biosynthesis GenProp0305: cysteine biosynthesis | |
| Literature References |
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| Gene Ontology Term | GO:0019344: cysteine biosynthetic process (biological_process) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| Sep-tRNA:Cys-tRNA synthase | pscS | YES | TIGR02539 (HMM): O-phospho-L-seryl-tRNA:Cys-tRNA synthase | GO:0019344: cysteine biosynthetic process |
| O-phosphoseryl-tRNA synthetase | sepS | YES | TIGR00470 (HMM): O-phosphoserine--tRNA ligase | GO:0019344: cysteine biosynthetic process |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0126 | amino acid biosynthesis |
| GenProp0197 | protein biosynthesis |
| GenProp0305 | cysteine biosynthesis |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0001 | chorismate biosynthesis via shikimate |
| GenProp0016 | selenocysteine system |
| GenProp0037 | tryptophan biosynthesis from ribose-5-phosphate |
| GenProp0039 | phenylalanine biosynthesis from chorismate |
| GenProp0045 | tyrosine biosynthesis from chorismate |
| GenProp0087 | arginine biosynthesis from glutatmate via N-acetylglutamate |
| GenProp0109 | histidine biosynthesis from ribose-5-phosphate |
| GenProp0111 | proline biosynthesis from glutamate |
| GenProp0117 | arginine biosynthesis from ornithine, carbamoyl-p and aspartate |
| GenProp0118 | ornithine biosynthesis from glutamate, acetylated branch |
| GenProp0159 | threonine biosynthesis from aspartate semialdehyde |
| GenProp0160 | aspartate semialdehyde biosynthesis from aspartate |
| GenProp0161 | methionine biosynthesis from homoserine |
| GenProp0162 | isoleucine biosynthesis from threonine and pyruvate |
| GenProp0163 | valine biosynthesis from pyruvate |
| GenProp0164 | leucine biosynthesis from pyruvate and acetyl-CoA |
| GenProp0178 | glycine cleavage system |
| GenProp0199 | lysine biosynthesis |
| GenProp0305 | cysteine biosynthesis |
| GenProp0729 | methionine salvage from methylthioadenosine |
| GenProp0797 | selenocysteinyl-tRNA, PSTK/SepSecS pathway |
| GenProp0312 | pyrrolysine |
| GenProp0132 | transcription termination - antitermination Nus factors |
| GenProp0148 | release factor 2 programmed frameshift |
| GenProp0174 | ribosome, bacterial, large subunit |
| GenProp0175 | ribosome, bacterial, small subunit |
| GenProp0188 | GatABC aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase complex |
| GenProp0189 | tRNA-Gln direct aminoacylation |
| GenProp0211 | tmRNA trans-translation system |
| GenProp0258 | tRNA aminoacylation |
| GenProp0259 | tRNA-Asn direct aminoacylation |
| GenProp0634 | Sigma-54 (RpoN) systems |
| GenProp0692 | selenouridine-containing tRNA |
| GenProp0704 | tRNA U34 carboxymethylaminomethyl modification |
| GenProp0740 | translation initiation, bacterial |
| GenProp0741 | translation elongation, bacterial |
| GenProp0746 | translation termination, bacterial |
| GenProp0812 | rho-dependent termination |
| GenProp0218 | cysteine biosynthesis from serine |