Genome Property Definition Page

Namehistidine biosynthesis from ribose-5-phosphate
DescriptionHistidine is synthesized in a ten step pathway from phosphoribosyl-pyrophosphate. It is found in bacteria, archaebacteria, fungi, and plants. The early stage of this pathway takes a ribose and transforms it into Imadiazoleglycerol phosphate. Once the imadiazole ring is formed, glutamate donates the a-amino group and the newly formed amine is oxidized to histidine.[1] In Salmonella typhimurium and Escherichia coli, this pathway is carried out by the eight genes in his operon. HisI, hisB, hisD are bifunctional enzymes, hisF and hisH form a monofunctional dimer, and the rest are monofunctional enzymes.[1]
JCVI RoleHistidine family
Parent PropertyGenProp0126: amino acid biosynthesis
Literature References
[ 1 ]Barbosa JA, Sivaraman J, Li Y, Larocque R, Matte A, Schrag JD, Cygler M.  Mechanism of action and NAD+-binding mode revealed by the crystal structure of L-histidinol dehydrogenase.  Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1859-64. Epub 2002 Feb 12.  PMID 11842181
[ 2 ]Alifano P, Fani R, Lio P, Lazcano A, Bazzicalupo M, Carlomagno MS, Bruni CB.  Histidine biosynthetic pathway and genes: structure, regulation, and evolution.  Microbiol Rev. 1996 Mar;60(1):44-69.  PMID 8852895
Web ReferencesKEGG: Histidine Metabolism
IUBMB: Histidine Biosynthesis (early stages)
IUBMB: Histidine Biosynthesis (late stages)
Gene Ontology TermGO:0000105: histidine biosynthetic process (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
ribose-phosphate pyrophosphokinaseYESTIGR01251 (HMM): ribose-phosphate diphosphokinaseGO:0000105: histidine biosynthetic process
phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomeraseHisAYESTIGR00007 (HMM): 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase
TIGR02129 (HMM): phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
TIGR01919 (HMM): bifunctional HisA/TrpF protein
GO:0000105: histidine biosynthetic process
GO:0000105: histidine biosynthetic process
GO:0000105: histidine biosynthetic process
imidazoleglycerol-phosphate dehydrataseHisBYESPF00475 (HMM): imidazoleglycerol-phosphate dehydrataseGO:0000105: histidine biosynthetic process
histidinol-phosphate aminotransferaseHisCYESTIGR01141 (HMM): histidinol-phosphate transaminaseGO:0000105: histidine biosynthetic process
histidinol dehydrogenaseHisDYESTIGR00069 (HMM): histidinol dehydrogenase
PF00815 (HMM): histidinol dehydrogenase
GO:0000105: histidine biosynthetic process
GO:0000105: histidine biosynthetic process
phosphoribosyl-ATP pyrophosphohydrolaseHisEYESPF01503 (HMM): phosphoribosyl-ATP diphosphatase
TIGR03188 (HMM): phosphoribosyl-ATP diphosphatase
GO:0000105: histidine biosynthetic process
GO:0000105: histidine biosynthetic process
imidazoleglycerol phosphate synthase, cyclase subunitHisFYESTIGR00735 (HMM): imidazoleglycerol phosphate synthase, cyclase subunitGO:0000105: histidine biosynthetic process
ATP phosphoribosyltransferaseHisGYESTIGR00070 (HMM): ATP phosphoribosyltransferase
PF01634 (HMM): ATP phosphoribosyltransferase
GO:0000105: histidine biosynthetic process
GO:0000105: histidine biosynthetic process
HisG, C-terminal domainHisG_CNOPF08029 (HMM): HisG, C-terminal domain
TIGR03455 (HMM): ATP phosphoribosyltransferase, C-terminal domain
GO:0000105: histidine biosynthetic process
GO:0000105: histidine biosynthetic process
imidazoleglycerol phosphate synthase, glutamine amidotransferase subunitHisHYESTIGR01855 (HMM): imidazole glycerol phosphate synthase, glutamine amidotransferase subunitGO:0000105: histidine biosynthetic process
phosphoribosyl-AMP cyclohydrolaseHisIYESPF01502 (HMM): phosphoribosyl-AMP cyclohydrolaseGO:0000105: histidine biosynthetic process
histidinol-phosphate phosphataseHisJNOTIGR01261 (HMM): histidinol-phosphatase
TIGR01856 (HMM): histidinol phosphate phosphatase, HisJ family
TIGR02067 (HMM): histidinol-phosphatase
GO:0000105: histidine biosynthetic process
his operon leader peptideHisLNOPF08047 (HMM): histidine operon leader peptide
ATP phosphoribosyltransferase regulatory subunitHisZNOTIGR00443 (HMM): ATP phosphoribosyltransferase, regulatory subunitGO:0000105: histidine biosynthetic process

Parent Properties
GenProp0126amino acid biosynthesis

Sibling Properties
GenProp0001chorismate biosynthesis via shikimate
GenProp0016selenocysteine system
GenProp0037tryptophan biosynthesis from ribose-5-phosphate
GenProp0039phenylalanine biosynthesis from chorismate
GenProp0045tyrosine biosynthesis from chorismate
GenProp0087arginine biosynthesis from glutatmate via N-acetylglutamate
GenProp0111proline biosynthesis from glutamate
GenProp0117arginine biosynthesis from ornithine, carbamoyl-p and aspartate
GenProp0118ornithine biosynthesis from glutamate, acetylated branch
GenProp0159threonine biosynthesis from aspartate semialdehyde
GenProp0160aspartate semialdehyde biosynthesis from aspartate
GenProp0161methionine biosynthesis from homoserine
GenProp0162isoleucine biosynthesis from threonine and pyruvate
GenProp0163valine biosynthesis from pyruvate
GenProp0164leucine biosynthesis from pyruvate and acetyl-CoA
GenProp0178glycine cleavage system
GenProp0199lysine biosynthesis
GenProp0304cysteine biosynthesis, tRNA-dependent
GenProp0305cysteine biosynthesis
GenProp0729methionine salvage from methylthioadenosine
GenProp0797selenocysteinyl-tRNA, PSTK/SepSecS pathway