Genome Property Definition Page
| Accession | GenProp0111 |
| Name | proline biosynthesis from glutamate |
| Type | PATHWAY |
| Description | The amino acid proline is synthesized in three steps from glutamate via L-glutamate-5-semialdehyde which non-enzymatically cyclizes to delta-1-pyrroline-5-carboxylate. Glutamate semialdehyde can also arise from transamination of ornithine. Proline may also be synthesized directly from ornithine by the action of ornithine cyclodeaminase. |
| JCVI Role | Glutamate family |
| Parent Property | GenProp0126: amino acid biosynthesis |
| Web References | KEGG: Arginine and proline metabolism IUBMB: Proline Biosynthesis |
| Gene Ontology Term | GO:0006561: proline biosynthetic process (biological_process) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| glutamate 5-kinase | 1 | YES | TIGR01027 (HMM): glutamate 5-kinase | GO:0006561: proline biosynthetic process |
| glutamate-5-semialdehyde dehydrogenase | 2 | YES | TIGR00407 (HMM): glutamate-5-semialdehyde dehydrogenase | GO:0006561: proline biosynthetic process |
| pyrroline-5-carboxylate reductase | 3 | YES | TIGR00112 (HMM): pyrroline-5-carboxylate reductase | GO:0006561: proline biosynthetic process |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0126 | amino acid biosynthesis |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0001 | chorismate biosynthesis via shikimate |
| GenProp0016 | selenocysteine system |
| GenProp0037 | tryptophan biosynthesis from ribose-5-phosphate |
| GenProp0039 | phenylalanine biosynthesis from chorismate |
| GenProp0045 | tyrosine biosynthesis from chorismate |
| GenProp0087 | arginine biosynthesis from glutatmate via N-acetylglutamate |
| GenProp0109 | histidine biosynthesis from ribose-5-phosphate |
| GenProp0117 | arginine biosynthesis from ornithine, carbamoyl-p and aspartate |
| GenProp0118 | ornithine biosynthesis from glutamate, acetylated branch |
| GenProp0159 | threonine biosynthesis from aspartate semialdehyde |
| GenProp0160 | aspartate semialdehyde biosynthesis from aspartate |
| GenProp0161 | methionine biosynthesis from homoserine |
| GenProp0162 | isoleucine biosynthesis from threonine and pyruvate |
| GenProp0163 | valine biosynthesis from pyruvate |
| GenProp0164 | leucine biosynthesis from pyruvate and acetyl-CoA |
| GenProp0178 | glycine cleavage system |
| GenProp0199 | lysine biosynthesis |
| GenProp0304 | cysteine biosynthesis, tRNA-dependent |
| GenProp0305 | cysteine biosynthesis |
| GenProp0729 | methionine salvage from methylthioadenosine |
| GenProp0797 | selenocysteinyl-tRNA, PSTK/SepSecS pathway |