Genome Property Definition Page
| Accession | GenProp0159 |
| Name | threonine biosynthesis from aspartate semialdehyde |
| Type | PATHWAY |
| Description | Threonine is made from aspartate semialdehyde, a branch point intermediate in the synthesis of lysine. The aspartate semialdehyde is derived from aspartate, which in turn is derived from the Krebs cycle intermediate oxaloacetate. Homoserine, an intermediate in this pathway is a branchpoint for the biosynthesis of methionine. Threonine itself is utilized as a starting point for the biosynthesis of isoleucine. |
| JCVI Role | Aspartate family |
| Parent Property | GenProp0126: amino acid biosynthesis |
| Web References | IUBMB: Threonine Biosynthesis KEGG: Glycine, serine and threonine metabolism |
| Gene Ontology Term | GO:0009088: threonine biosynthetic process (biological_process) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| homoserine dehydrogenase | HS_DH | YES | PF00742 (HMM): homoserine dehydrogenase | GO:0009088: threonine biosynthetic process |
| homoserine kinase | HS_kin | YES | TIGR00191 (HMM): homoserine kinase TIGR00938 (HMM): homoserine kinase TIGR02137 (HMM): phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein | GO:0009088: threonine biosynthetic process GO:0009088: threonine biosynthetic process GO:0009088: threonine biosynthetic process |
| hypothetical NOD for homoserine kinase | hyp_HSK | NO | TIGR02535 (HMM): proposed homoserine kinase | |
| threonine synthase | thr_syn | YES | TIGR00260 (HMM): threonine synthase | GO:0009088: threonine biosynthetic process |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0126 | amino acid biosynthesis |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0001 | chorismate biosynthesis via shikimate |
| GenProp0016 | selenocysteine system |
| GenProp0037 | tryptophan biosynthesis from ribose-5-phosphate |
| GenProp0039 | phenylalanine biosynthesis from chorismate |
| GenProp0045 | tyrosine biosynthesis from chorismate |
| GenProp0087 | arginine biosynthesis from glutatmate via N-acetylglutamate |
| GenProp0109 | histidine biosynthesis from ribose-5-phosphate |
| GenProp0111 | proline biosynthesis from glutamate |
| GenProp0117 | arginine biosynthesis from ornithine, carbamoyl-p and aspartate |
| GenProp0118 | ornithine biosynthesis from glutamate, acetylated branch |
| GenProp0160 | aspartate semialdehyde biosynthesis from aspartate |
| GenProp0161 | methionine biosynthesis from homoserine |
| GenProp0162 | isoleucine biosynthesis from threonine and pyruvate |
| GenProp0163 | valine biosynthesis from pyruvate |
| GenProp0164 | leucine biosynthesis from pyruvate and acetyl-CoA |
| GenProp0178 | glycine cleavage system |
| GenProp0199 | lysine biosynthesis |
| GenProp0304 | cysteine biosynthesis, tRNA-dependent |
| GenProp0305 | cysteine biosynthesis |
| GenProp0729 | methionine salvage from methylthioadenosine |
| GenProp0797 | selenocysteinyl-tRNA, PSTK/SepSecS pathway |