Genome Property Definition Page

Accession

GenProp0193

Name

lysine biosynthesis via alpha-aminoadipate (AAA pathway)

Type

PATHWAY

Description

Lysine biosynthesis in fungi has been characterized and begins with the condensation of 2-oxoglutarate and acetyl-CoA to homocitrate and continues through the distinctive intermediate, alpha-aminoadipate. This pathway is distinct in every respect from the diaminopimelate pathway commonly found in bacteria and animals. Recently, an alpha-aminoadipate pathway closely related to the fungal version has been characterized in Thermus thermophilus [1] and appears to be widely distributed among the archaea.

Parent Property

GenProp0199: lysine biosynthesis

Literature References

[ 1 ]Nishida H, Nishiyama M, Kobashi N, Kosuge T, Hoshino T, Yamane H A prokaryotic gene cluster involved in synthesis of lysine through the amino adipate pathway: a key to the evolution of amino acid biosynthesis Genome Res. 1999 Dec;9(12):1175-83 PMID 10613839

Components

Step Name	Step Num	Required	Evidence (Method)
homocitrate dehydrogenase	Lys?	NO
aminotransferase	LysJ	YES	TIGR00707 (HMM): transaminase, acetylornithine/succinylornithine family
acylase	LysK	YES	TIGR01902 (HMM): N-acetyl-ornithine/N-acetyl-lysine deacetylase
homocitrate synthase	LysS	YES	TIGR00977 (HMM): citramalate synthase TIGR02090 (HMM): isopropylmalate/citramalate/homocitrate synthases TIGR02146 (HMM): homocitrate synthase
homoaconitate hydratase, LysT subunit	LysT	YES	TIGR02083 (HMM): 3-isopropylmalate dehydratase, large subunit TIGR01343 (HMM): homoaconitate hydratase family protein
homoaconitate hydratase, LysU subunit	LysU	YES	TIGR02087 (HMM): 3-isopropylmalate dehydratase, small subunit
alpha-aminoadipate acylase (proposed)	LysX	YES	TIGR02144 (HMM): lysine biosynthesis enzyme LysX
epsilon-dehydrogenase (proposed)	LysY	YES	TIGR01850 (HMM): N-acetyl-gamma-glutamyl-phosphate reductase
epsilon-carboxykinase (proposed)	LysZ	YES	TIGR00761 (HMM): acetylglutamate kinase

Parent Properties

Accession	Name
GenProp0199	lysine biosynthesis

Sibling Properties

Accession	Name
GenProp0125	lysine biosynthesis via diaminopimelate (DAP)
GenProp0788	lysine biosynthesis via diaminopimelate (DAP) utilizing ammonia and NADPH