Genome Property Definition Page

Namelysine biosynthesis via alpha-aminoadipate (AAA pathway)
DescriptionLysine biosynthesis in fungi has been characterized and begins with the condensation of 2-oxoglutarate and acetyl-CoA to homocitrate and continues through the distinctive intermediate, alpha-aminoadipate. This pathway is distinct in every respect from the diaminopimelate pathway commonly found in bacteria and animals. Recently, an alpha-aminoadipate pathway closely related to the fungal version has been characterized in Thermus thermophilus [1] and appears to be widely distributed among the archaea.
Parent PropertyGenProp0199: lysine biosynthesis
Literature References
[ 1 ]Nishida H, Nishiyama M, Kobashi N, Kosuge T, Hoshino T, Yamane H  A prokaryotic gene cluster involved in synthesis of lysine through the amino adipate pathway: a key to the evolution of amino acid biosynthesis  Genome Res. 1999 Dec;9(12):1175-83  PMID 10613839

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
homocitrate dehydrogenaseLys?NO
aminotransferaseLysJYESTIGR00707 (HMM): transaminase, acetylornithine/succinylornithine family
acylaseLysKYESTIGR01902 (HMM): N-acetyl-ornithine/N-acetyl-lysine deacetylase
homocitrate synthaseLysSYESTIGR00977 (HMM): citramalate synthase
TIGR02090 (HMM): isopropylmalate/citramalate/homocitrate synthases
TIGR02146 (HMM): homocitrate synthase
homoaconitate hydratase, LysT subunitLysTYESTIGR02083 (HMM): 3-isopropylmalate dehydratase, large subunit
TIGR01343 (HMM): homoaconitate hydratase family protein
homoaconitate hydratase, LysU subunitLysUYESTIGR02087 (HMM): 3-isopropylmalate dehydratase, small subunit
alpha-aminoadipate acylase (proposed)LysXYESTIGR02144 (HMM): lysine biosynthesis enzyme LysX
epsilon-dehydrogenase (proposed)LysYYESTIGR01850 (HMM): N-acetyl-gamma-glutamyl-phosphate reductase
epsilon-carboxykinase (proposed)LysZYESTIGR00761 (HMM): acetylglutamate kinase

Parent Properties
GenProp0199lysine biosynthesis

Sibling Properties
GenProp0125lysine biosynthesis via diaminopimelate (DAP)
GenProp0788lysine biosynthesis via diaminopimelate (DAP) utilizing ammonia and NADPH