Genome Property Definition Page

NameruvABC Holliday junction complex
DescriptionRuvA, RuvB and RuvC proteins together act on Holliday junctions for homologous recombination and DNA repair. RuvAB is the branch migration complex and RuvC the resolvase. The system is strictly bacterial; proteins with little or no detectable sequence similarity process Holliday junctions in Archaea, eukaryotes, and some phage. A variety of Holliday junction-cleaving (Hjc) enzymes have been found in the Archaea (PMID:12382111). Holliday junction resolvases, including RuvC, Hjc and Hje, CCE1 (yeast) and A22R (poxviruses) are reviewed by Sharples (PMID:11251805). RuvC is replaced by RecU in firmicutes and mollicutes.
JCVI RoleDNA replication, recombination, and repair
Parent PropertyGenProp0076: DNA handling
GenProp0115: DNA repair
GenProp0116: DNA metabolism
Literature References
[ 1 ]Dickman MJ, Ingleston SM, Sedelnikova SE, Rafferty JB, Lloyd RG, Grasby JA, Hornby DP.  The RuvABC resolvasome.  Eur J Biochem. 2002 Nov;269(22):5492-501.  PMID 12423347
[ 2 ]Neef K, Birkenbihl RP, Kemper B.  Holliday junction-resolving enzymes from eight hyperthermophilic archaea differ in reactions with cruciform DNA.  Extremophiles. 2002 Oct;6(5):359-67. Epub 2002 Apr 18.  PMID 12382111
[ 3 ]Sharples GJ.  The X philes: structure-specific endonucleases that resolve Holliday junctions.  Mol Microbiol. 2001 Feb;39(4):823-34. Review.  PMID 11251805
Gene Ontology TermGO:0000725: recombinational repair (biological_process)
GO:0006310: DNA recombination (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
RuvA subunit, Holliday junction DNA helicaseruvAYESTIGR00084 (HMM): Holliday junction DNA helicase RuvAGO:0000725: recombinational repair
GO:0006310: DNA recombination
RuvB subunit, Holliday junction DNA helicaseruvBYESTIGR00635 (HMM): Holliday junction DNA helicase RuvBGO:0000725: recombinational repair
GO:0006310: DNA recombination
RuvC (or RecU) resolvaseruvCYESTIGR00228 (HMM): crossover junction endodeoxyribonuclease RuvC
TIGR00648 (HMM): recombination protein U
GO:0000725: recombinational repair
GO:0006310: DNA recombination
GO:0000725: recombinational repair
GO:0006310: DNA recombination

Parent Properties
GenProp0076DNA handling
GenProp0115DNA repair
GenProp0116DNA metabolism

Sibling Properties
GenProp0018natural transformation
GenProp0056type IV pilus
GenProp0115DNA repair
GenProp0311competence-related genes
GenProp0489F-type conjugation system
GenProp0490Ti-type conjugation system
GenProp0699DNA gyrase
GenProp0851integration host factor
GenProp0855integrating conjugative element, PFGI-1 class
GenProp0858conjugative transposon, Bacteroides type
GenProp0114nucleotide excision repair
GenProp0215SOS response
GenProp0216recBCD pathway
GenProp0224nucleotide excision repair, alternative pathway
GenProp0225mismatch repair
GenProp0227excision repair
GenProp0228direct repair
GenProp0491recFOR recombination pathway
GenProp0492nonhomologous end-joining, bacterial type
GenProp0493addAB pathway
GenProp0767very short patch repair
GenProp10998-oxoguanine DNA repair
GenProp0263DNA polymerase III, bacterial
GenProp0455restriction enzyme system, type I
GenProp0487repABC-type alpha-proteobacterial replicon(s)
GenProp0650type II restriction system, Alw26I/Eco31I/Esp3I family
GenProp0701DNA sulfur modification system dnd
GenProp0806replication initiation, bacterial
GenProp0977DNA ligase/helicase system
GenProp1081replication restart, PriA/PriB primosome pathway
GenProp1095exodeoxyribonuclease VII