Genome Property Definition Page

Accession

GenProp0216

Name

recBCD pathway

Type

SYSTEM

Description

This property describes the presence of genes for the RecBCD protein complex, which participates in at least two different processes. As exodeoxyribonuclease V, it degrades linear double-stranded DNA, as might occur by cleavage of exogenous DNA by restriction systems. It also acts to repair double-stranded breaks in DNA by homologous recombination; genera that lack this complex tend to show stronger conservation of gene order between species. The RecBCD heterotrimer interacts with instances of the DNA sequence GCTGGTGG in E. coli, called Chi, which are recombinational hotspots. RecBCD promotes loading the strand exchange protein RecA onto chi-containing DNA. Double-stranded breaks are processed by AddAB rather than by RecBCD in the Firmicutes and in alpha-Proteobacteria.

JCVI Role

DNA replication, recombination, and repair

Parent Property

GenProp0115: DNA repair

Literature References

[ 1 ]Nakamura Y, Nishio Y, Ikeo K, Gojobori T The genome stability in Corynebacterium species due to lack of the recombinational repair system. Gene 2003 Oct 23;317(1-2):149-55. PMID 14604803
[ 2 ]Taylor AF, Smith GR RecBCD enzyme is a DNA helicase with fast and slow motors of opposite polarity. Nature 2003 Jun 19;423(6942):889-93. PMID 12815437

Gene Ontology Term

GO:0000725: recombinational repair (biological_process)
GO:0000738: DNA catabolic process, exonucleolytic (biological_process)

Components

Step Name	Step Num	Required	Evidence (Method)	Evidence Go Terms
exodeoxyribonuclease V, beta subunit	recB	YES	TIGR00609 (HMM): exodeoxyribonuclease V, beta subunit	GO:0000725: recombinational repair GO:0000738: DNA catabolic process, exonucleolytic
exodeoxyribonuclease V, gamma subunit	recC	YES	TIGR01450 (HMM): exodeoxyribonuclease V, gamma subunit	GO:0000725: recombinational repair GO:0000738: DNA catabolic process, exonucleolytic
exodeoxyribonuclease V, alpha subunit	recD	YES	TIGR01447 (HMM): exodeoxyribonuclease V, alpha subunit	GO:0000725: recombinational repair GO:0000738: DNA catabolic process, exonucleolytic

Parent Properties

Accession	Name
GenProp0115	DNA repair

Sibling Properties

Accession	Name
GenProp0114	nucleotide excision repair
GenProp0198	ruvABC Holliday junction complex
GenProp0215	SOS response
GenProp0224	nucleotide excision repair, alternative pathway
GenProp0225	mismatch repair
GenProp0227	excision repair
GenProp0228	direct repair
GenProp0491	recFOR recombination pathway
GenProp0492	nonhomologous end-joining, bacterial type
GenProp0493	addAB pathway
GenProp0767	very short patch repair
GenProp1099	8-oxoguanine DNA repair