Genome Property Definition Page

Namevery short patch repair
DescriptionVery short patch (VSP) repair is a repair system that recognizes mismatches caused by deamination of 5-methylcytosine (5meC). Cytosine is modified to 5meC by the product of the dcm gene. Vsr is an endonuclease that creates a nick to allow the repair. In Escherichia coli, the second C of the DNA motif CCWGG (where W is A or T) is methylated; deamination yields T:G mispairs reccognized by the vsr gene product. The vsr gene typically is found very close to the dcm gene, and is essentially restricted to a subset of those genomes that carry dcm.
Parent PropertyGenProp0115: DNA repair
Literature References
[ 1 ] Lieb M, Bhagwat AS   Very short patch repair: reducing the cost of cytosine methylation.   Mol Microbiol. 1996 May;20(3):467-73.  PMID 8736526

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
DNA-cytosine methyltransferasedcmYESTIGR00675 (HMM-CLUST): DNA (cytosine-5-)-methyltransferase
very short patch repairvsrYESTIGR00632 (HMM): DNA mismatch endonuclease Vsr

Parent Properties
GenProp0115DNA repair

Sibling Properties
GenProp0114nucleotide excision repair
GenProp0198ruvABC Holliday junction complex
GenProp0215SOS response
GenProp0216recBCD pathway
GenProp0224nucleotide excision repair, alternative pathway
GenProp0225mismatch repair
GenProp0227excision repair
GenProp0228direct repair
GenProp0491recFOR recombination pathway
GenProp0492nonhomologous end-joining, bacterial type
GenProp0493addAB pathway
GenProp10998-oxoguanine DNA repair