| Accession | GenProp0263 |
| Name | DNA polymerase III, bacterial |
| Type | SYSTEM |
| Description | This property represents bacterial DNA polymerase III, a multisubunit replicative enzyme. In addition to core subunits, various bacteria may have accessory proteins that confer special properties such as greater speed and processivity. The single subunit in Gram-positive bacteria that carries polymerase and 3'-5' proofreading exonuclease activities corresponds to separate alpha (dnaE) and epsilon (dnaQ) subunits in E. coli. The polymerase works together with a clamp (beta, dnaN) and a clamp-loading complex of delta, delta-prime, and tau. In some species, a gamma subunit is related to tau by a translational frameshift from the same gene, dnaX. Some known accessory subunits include chi, psi, and theta. |
| JCVI Role | DNA replication, recombination, and repair |
| Parent Property | GenProp0116: DNA metabolism
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| Literature References | [ 1 ]Song MS, Pham PT, Olson M, Carter JR, Franden MA, Schaaper RM, McHenry CS The delta and delta ' subunits of the DNA polymerase III holoenzyme are essential for initiation complex formation and processive elongation. J Biol Chem. 2001 Sep 14;276(37):35165-75. Epub 2001 Jun 29. PMID 11432857
[ 2 ]Bruck I, O'Donnell M The DNA replication machine of a gram-positive organism. J Biol Chem. 2000 Sep 15;275(37):28971-83. PMID 10878011
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| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|
| DNA polymerase III, alpha subunit (DnaE) | dnaE | YES | TIGR00594 (HMM): DNA polymerase III, alpha subunit | |
| DNA polymerase III, beta subunit (dnaN) | dnaN | YES | TIGR00663 (HMM): DNA polymerase III, beta subunit | |
| DNA polymerase III, epsilon subunit (dnaQ) | dnaQ | YES | TIGR01406 (HMM): DNA polymerase III, epsilon subunit | |
| DNA polymerase III, gamma and tau subunits (dnaX) | dnaX | YES | TIGR02397 (HMM): DNA polymerase III, subunit gamma and tau | |
| DNA polymerase III, delta subunit | holA | YES | TIGR01128 (HMM): DNA polymerase III, delta subunit | |
| DNA polymerase III, delta prime subunit | holB | YES | TIGR00678 (HMM): DNA polymerase III, delta' subunit | |
| DNA polymerase III, chi subunit (holC) | holC | YES | PF04364 (HMM): DNA polymerase III, chi subunit | |
| DNA polymerase III, psi subunit (holD) | holD | YES | TIGR00664 (HMM): DNA polymerase III, psi subunit | |
| DNA polymerase III, theta subunit (holE) | holE | NO | PF06440 (HMM): DNA polymerase III, theta subunit | |
| DNA polymerase III, alpha subunit, PolC-type | polC | NO | TIGR01405 (HMM): DNA polymerase III, alpha subunit, Gram-positive type | |
