Genome Property Definition Page

Namereplication restart, PriA/PriB primosome pathway
DescriptionThe bacterial primosome, as in E. coli, restarts replication at sites away from oriC (where DnaA acts), the normal origin of replication. PriB is a member of the larger family of single-stranded DNA-binding (ssb) protein. It is nearly always located between the genes for ribosomal protein S6 and S18, but appears to be only a subset of such ssb family members. The ssb member from the same location in most genomes is longer, and more closely related to a paralog of E. coli PriB than to PriB itself.
JCVI RoleDNA replication, recombination, and repair
Parent PropertyGenProp0116: DNA metabolism
Literature References
[ 1 ]Lopper M, Boonsombat R, Sandler SJ, Keck JL  A hand-off mechanism for primosome assembly in replication restart.  Mol Cell. 2007 Jun 22;26(6):781-93.  PMID 17588514
[ 2 ]Szymanski MR, Jezewska MJ, Bujalowski W  Binding of two PriA-PriB complexes to the primosome assembly site initiates primosome formation.  J Mol Biol. 2011 Aug 5;411(1):123-42.  PMID 21641914
Gene Ontology TermGO:0006269: DNA replication, synthesis of RNA primer (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
primosomal protein DnaTDnaTNO
primosome helicase PriAPriAYESTIGR00595 (HMM): primosomal protein N'GO:0006269: DNA replication, synthesis of RNA primer
primosome protein PriBPriBYESTIGR04418 (HMM): primosomal replication protein PriBGO:0006269: DNA replication, synthesis of RNA primer

Parent Properties
GenProp0116DNA metabolism

Sibling Properties
GenProp0115DNA repair
GenProp0198ruvABC Holliday junction complex
GenProp0263DNA polymerase III, bacterial
GenProp0455restriction enzyme system, type I
GenProp0487repABC-type alpha-proteobacterial replicon(s)
GenProp0650type II restriction system, Alw26I/Eco31I/Esp3I family
GenProp0701DNA sulfur modification system dnd
GenProp0806replication initiation, bacterial
GenProp0977DNA ligase/helicase system
GenProp1095exodeoxyribonuclease VII