Accession | GenProp1081 |
Name | replication restart, PriA/PriB primosome pathway |
Type | SYSTEM |
Description | The bacterial primosome, as in E. coli, restarts replication at sites away from oriC (where DnaA acts), the normal origin of replication. PriB is a member of the larger family of single-stranded DNA-binding (ssb) protein. It is nearly always located between the genes for ribosomal protein S6 and S18, but appears to be only a subset of such ssb family members. The ssb member from the same location in most genomes is longer, and more closely related to a paralog of E. coli PriB than to PriB itself. |
JCVI Role | DNA replication, recombination, and repair |
Parent Property | GenProp0116: DNA metabolism
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Literature References | [ 1 ]Lopper M, Boonsombat R, Sandler SJ, Keck JL A hand-off mechanism for primosome assembly in replication restart. Mol Cell. 2007 Jun 22;26(6):781-93. PMID 17588514 [ 2 ]Szymanski MR, Jezewska MJ, Bujalowski W Binding of two PriA-PriB complexes to the primosome assembly site initiates primosome formation. J Mol Biol. 2011 Aug 5;411(1):123-42. PMID 21641914 |
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Gene Ontology Term | GO:0006269: DNA replication, synthesis of RNA primer (biological_process)
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