Genome Property Definition Page

Nameexodeoxyribonuclease VII
DescriptionExonuclease VII, consisting of a large subunit XseA and small subunit XseB, hydrolyzes single-stranded DNA. It acts in DNA mismatch repair and homologous recombination.
JCVI RoleDNA replication, recombination, and repair
Parent PropertyGenProp0116: DNA metabolism
Literature References
[ 1 ]Poleszak K, Kaminska KH, Dunin-Horkawicz S, Lupas A, Skowronek KJ, Bujnicki JM  Delineation of structural domains and identification of functionally important residues in DNA repair enzyme exonuclease VII.  Nucleic Acids Res. 2012 Sep;40(16):8163-74. doi: 10.1093/nar/gks547.  PMID 22718974
[ 2 ]Larrea AA, Pedroso IM, Malhotra A, Myers RS  Identification of two conserved aspartic acid residues required for DNA digestion by a novel thermophilic Exonuclease VII in Thermotoga maritima.  Nucleic Acids Res. 2008 Oct;36(18):5992-6003. doi: 10.1093/nar/gkn588.  PMID 18812402

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
exodeoxyribonuclease VII large subunitXseAYESTIGR00237 (HMM): exodeoxyribonuclease VII, large subunit
exodeoxyribonuclease VII small subunitXseBYESPF02609 (HMM): exodeoxyribonuclease VII, small subunit
TIGR01280 (HMM): exodeoxyribonuclease VII, small subunit

Parent Properties
GenProp0116DNA metabolism

Sibling Properties
GenProp0115DNA repair
GenProp0198ruvABC Holliday junction complex
GenProp0263DNA polymerase III, bacterial
GenProp0455restriction enzyme system, type I
GenProp0487repABC-type alpha-proteobacterial replicon(s)
GenProp0650type II restriction system, Alw26I/Eco31I/Esp3I family
GenProp0701DNA sulfur modification system dnd
GenProp0806replication initiation, bacterial
GenProp0977DNA ligase/helicase system
GenProp1081replication restart, PriA/PriB primosome pathway