Genome Property Definition Page
| Accession | GenProp0114 |
| Name | nucleotide excision repair |
| Type | SYSTEM |
| Description | One mechanism of DNA repair is nucleotide excision repair. Single-stranded cuts are made on both sides of a DNA lesion and the oligomer between the cuts is removed. Very few species lack this mechanism, although the insect endosymbiont Buchnera aphidicola is an example. In bacteria, the excinuclease UvrABC performs only this function, so the presence of any one of the three subunits suggests the mechanism is (or was) present. Also required is UvrD or a related helicase with similar effect, but this helicase acts in other processes as well. A large number of genes are active in eukaryotes. The characteristic size of the oligomer removed is also different in eukaryotes. The status of nucleotide excision repair in the archaea is not fully defined. |
| JCVI Role | DNA replication, recombination, and repair |
| Parent Property | GenProp0115: DNA repair |
| Gene Ontology Term | GO:0006289: nucleotide-excision repair (biological_process) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| excinuclease ABC subunit A | uvrA | YES | TIGR00630 (HMM): excinuclease ABC subunit A | GO:0006289: nucleotide-excision repair |
| excinuclease ABC subunit B | uvrB | YES | TIGR00631 (HMM): excinuclease ABC subunit B | GO:0006289: nucleotide-excision repair |
| excinuclease ABC subunit C | uvrC | YES | TIGR00194 (HMM): excinuclease ABC subunit C | GO:0006289: nucleotide-excision repair |
| DNA helicase II | uvrD | NO | TIGR01075 (HMM): DNA helicase II | GO:0006289: nucleotide-excision repair |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0115 | DNA repair |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0198 | ruvABC Holliday junction complex |
| GenProp0215 | SOS response |
| GenProp0216 | recBCD pathway |
| GenProp0224 | nucleotide excision repair, alternative pathway |
| GenProp0225 | mismatch repair |
| GenProp0227 | excision repair |
| GenProp0228 | direct repair |
| GenProp0491 | recFOR recombination pathway |
| GenProp0492 | nonhomologous end-joining, bacterial type |
| GenProp0493 | addAB pathway |
| GenProp0767 | very short patch repair |
| GenProp1099 | 8-oxoguanine DNA repair |