Genome Property Definition Page

Namenucleotide excision repair
DescriptionOne mechanism of DNA repair is nucleotide excision repair. Single-stranded cuts are made on both sides of a DNA lesion and the oligomer between the cuts is removed. Very few species lack this mechanism, although the insect endosymbiont Buchnera aphidicola is an example. In bacteria, the excinuclease UvrABC performs only this function, so the presence of any one of the three subunits suggests the mechanism is (or was) present. Also required is UvrD or a related helicase with similar effect, but this helicase acts in other processes as well. A large number of genes are active in eukaryotes. The characteristic size of the oligomer removed is also different in eukaryotes. The status of nucleotide excision repair in the archaea is not fully defined.
JCVI RoleDNA replication, recombination, and repair
Parent PropertyGenProp0115: DNA repair
Gene Ontology TermGO:0006289: nucleotide-excision repair (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
excinuclease ABC subunit AuvrAYESTIGR00630 (HMM): excinuclease ABC subunit AGO:0006289: nucleotide-excision repair
excinuclease ABC subunit BuvrBYESTIGR00631 (HMM): excinuclease ABC subunit BGO:0006289: nucleotide-excision repair
excinuclease ABC subunit CuvrCYESTIGR00194 (HMM): excinuclease ABC subunit CGO:0006289: nucleotide-excision repair
DNA helicase IIuvrDNOTIGR01075 (HMM): DNA helicase IIGO:0006289: nucleotide-excision repair

Parent Properties
GenProp0115DNA repair

Sibling Properties
GenProp0198ruvABC Holliday junction complex
GenProp0215SOS response
GenProp0216recBCD pathway
GenProp0224nucleotide excision repair, alternative pathway
GenProp0225mismatch repair
GenProp0227excision repair
GenProp0228direct repair
GenProp0491recFOR recombination pathway
GenProp0492nonhomologous end-joining, bacterial type
GenProp0493addAB pathway
GenProp0767very short patch repair
GenProp10998-oxoguanine DNA repair