Genome Property Definition Page
| Accession | GenProp0225 |
| Name | mismatch repair |
| Type | SYSTEM |
| Description | The combination of MutS (the MutS1 branch but not the MutS2 branch of the MutS family) and MutL leads to a general mechanism for mismatch exision and repair (MMR). Other proteins, recruited by MutS1 and MutL, act to clip (MutH or other endonuclease), remove (UvrD), and resynthesize one strand in the region containing the mismatch. MMR constrasts in its generality with the targeting of specific mismatches by various base excision repair (BER) glycosylases and with variants of MMR that act on specific mismatches. In Escherichia coli and related species that contain the endonuclease MutH and the DNA adenine methylation protein Dam, lack of methylation marks the newly synthesized strand; the mismatch is resolved by excision, removal, and resynthesis of a piece of that strand. MMR is referred to as methyl-directed mismatch repair in this subset of species with MMR. |
| JCVI Role | DNA replication, recombination, and repair |
| Parent Property | GenProp0115: DNA repair |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| MutH (or other) mismatch endonuclease | endonuc | NO | TIGR02248 (HMM): DNA mismatch repair endonuclease MutH | |
| DNA mismatch repair protein MutL | mutL | YES | TIGR00585 (HMM): DNA mismatch repair protein MutL | |
| DNA mismatch repair protein MutS (mutS1) | mutS1 | YES | TIGR01070 (HMM): DNA mismatch repair protein MutS |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0115 | DNA repair |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0114 | nucleotide excision repair |
| GenProp0198 | ruvABC Holliday junction complex |
| GenProp0215 | SOS response |
| GenProp0216 | recBCD pathway |
| GenProp0224 | nucleotide excision repair, alternative pathway |
| GenProp0227 | excision repair |
| GenProp0228 | direct repair |
| GenProp0491 | recFOR recombination pathway |
| GenProp0492 | nonhomologous end-joining, bacterial type |
| GenProp0493 | addAB pathway |
| GenProp0767 | very short patch repair |
| GenProp1099 | 8-oxoguanine DNA repair |