Genome Property Definition Page
Accession | GenProp0493 |
Name | addAB pathway |
Type | SYSTEM |
Description | The recBCD pathway, important in double stranded break DNA repair by homologous recombination, is replaced by AddAB in several bacterial lineages. The AddAB gene pairs are quite distant, in terms of sequence similarity, between that of Gram-positive bacteria and that of alphaproteobacteria. Note that an alternative, less common method of repair of double stranded breaks is nonhomologous end-joining (NHEJ), and that pathway may coexist with AddAB in a genome. In some species, AddAB is called RexAB. |
JCVI Role | DNA replication, recombination, and repair |
Parent Property | GenProp0115: DNA repair |
Gene Ontology Term | GO:0000724: double-strand break repair via homologous recombination (biological_process) |
Components
Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
---|---|---|---|---|
AddA protein | AddA | YES | TIGR02784 (HMM): double-strand break repair helicase AddA TIGR02785 (HMM): helicase-exonuclease AddAB, AddA subunit | GO:0000724: double-strand break repair via homologous recombination GO:0000724: double-strand break repair via homologous recombination |
AddB protein | AddB | YES | TIGR02786 (HMM): double-strand break repair protein AddB TIGR02773 (HMM): helicase-exonuclease AddAB, AddB subunit TIGR02774 (HMM): ATP-dependent nuclease subunit B | GO:0000724: double-strand break repair via homologous recombination GO:0000724: double-strand break repair via homologous recombination GO:0000724: double-strand break repair via homologous recombination |
Parent Properties
Accession | Name |
---|---|
GenProp0115 | DNA repair |
Sibling Properties
Accession | Name |
---|---|
GenProp0114 | nucleotide excision repair |
GenProp0198 | ruvABC Holliday junction complex |
GenProp0215 | SOS response |
GenProp0216 | recBCD pathway |
GenProp0224 | nucleotide excision repair, alternative pathway |
GenProp0225 | mismatch repair |
GenProp0227 | excision repair |
GenProp0228 | direct repair |
GenProp0491 | recFOR recombination pathway |
GenProp0492 | nonhomologous end-joining, bacterial type |
GenProp0767 | very short patch repair |
GenProp1099 | 8-oxoguanine DNA repair |