Accession | GenProp0492 |
Name | nonhomologous end-joining, bacterial type |
Type | SYSTEM |
Description | This property describes nonhomologous end-joining (NHEJ), a mechanism for DNA repair of double-stranded breaks that appears significantly less common in bacteria than, and uncorrelated with, recombinational repair. The bacterial Ku protein typically is encoded next to the multidomain, multifunctional DNA ligase, LidD. The domains of LigD, which may be permuted, carry separable 3'-phosphoesterase (PE), DNA ligase, and polymerase activities. |
JCVI Role | DNA replication, recombination, and repair |
Parent Property | GenProp0115: DNA repair
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Literature References | [ 1 ]Rocha EP, Cornet E, Michel B Comparative and evolutionary analysis of the bacterial homologous recombination systems. PLoS Genet. 2005 Aug;1(2):e15. PMID 16132081 [ 2 ]Zhu H, Wang LK, Shuman S Essential constituents of the 3'-phosphoesterase domain of bacterial DNA ligase D, a nonhomologous end-joining enzyme. J Biol Chem. 2005 Oct 7;280(40):33707-15. PMID 16046407 |
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Gene Ontology Term | GO:0006303: double-strand break repair via nonhomologous end joining (biological_process)
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Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
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Ku protein, bacterial type | Ku | YES | TIGR02772 (HMM): Ku protein | GO:0006303: double-strand break repair via nonhomologous end joining
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3-prime phosphoesterase domain | PE | NO | TIGR02777 (HMM): DNA ligase D, 3'-phosphoesterase domain | GO:0006303: double-strand break repair via nonhomologous end joining
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ligase domain | ligase | YES | TIGR02779 (HMM): DNA ligase D, ligase domain | GO:0006303: double-strand break repair via nonhomologous end joining
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polymerase domain | poly | YES | TIGR02778 (HMM): DNA ligase D, polymerase domain | GO:0006303: double-strand break repair via nonhomologous end joining
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