Genome Property Definition Page

Accession

GenProp1099

Name

8-oxoguanine DNA repair

Type

SYSTEM

Description

MutM excises 8-oxoguanine (8-oxoG) that has formed in DNA that has not since replicated (meaning it should be paired with C). If replication allows 8-oxoG to mispair with A, MutY excises the A to allow replication repair to replace it with a C. Note that MutT performs a different process, hydrolyzing 8-oxo-dGTP to 8-oxo-dGMP to block its incorporation into DNA in the first place, and therefore does perform DNA repair per se.

JCVI Role

DNA replication, recombination, and repair

Parent Property

GenProp0115: DNA repair

Literature References

[ 1 ]Hazra TK, Hill JW, Izumi T, Mitra S Multiple DNA glycosylases for repair of 8-oxoguanine and their potential in vivo functions. Prog Nucleic Acid Res Mol Biol. 2001;68:193-205. PMID 11554297

Components

Step Name	Step Num	Required	Evidence (Method)	Evidence Go Terms
DNA-formamidopyrimidine glycosylase	MutM	YES	TIGR00577 (HMM): DNA-formamidopyrimidine glycosylase
A/G-specific adenine glycosylase	MutY	YES	TIGR01084 (HMM): A/G-specific adenine glycosylase

Parent Properties

Accession	Name
GenProp0115	DNA repair

Sibling Properties

Accession	Name
GenProp0114	nucleotide excision repair
GenProp0198	ruvABC Holliday junction complex
GenProp0215	SOS response
GenProp0216	recBCD pathway
GenProp0224	nucleotide excision repair, alternative pathway
GenProp0225	mismatch repair
GenProp0227	excision repair
GenProp0228	direct repair
GenProp0491	recFOR recombination pathway
GenProp0492	nonhomologous end-joining, bacterial type
GenProp0493	addAB pathway
GenProp0767	very short patch repair