| Accession | GenProp0491 |
| Name | recFOR recombination pathway |
| Type | SYSTEM |
| Description | RecFOR is a system for homologous recombination, a nearly universal housekeeping process especially important for repair. RecFOR acts independently from the RecBCD system, or the AddAB system that replaces RecBCD in certain lineages, and the presence of RecFOR is actually positively correlated with the presence of RecBCD/AddAB, so these two presynaptic systems that act in loading RecA may be regarded as complementary. RecFOR especially repairs single-stranded gaps while RecBCD/AddAB repairs double-stranded DNA ends, although roles for RecFOR in double stranded break repair are shown in discussion of RecN and RecQ function and of recBCD mutants. RecFOR systems often are assisted in an early step by the exonuclease RecJ. Following strand exchange by RecA, Holliday junction resolution may be done by RuvABC or RecG. The action of the RecFOR pathway involves formation of RecOR complexes, and RecFR complexes, but no complex of all three. Of the three genes, either RecO or RecF may be missing while the other two components are present, but RecR must be present in genomes with any part of this system. |
| JCVI Role | DNA replication, recombination, and repair |
| Parent Property | GenProp0115: DNA repair
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| Literature References | [ 1 ]Rocha EP, Cornet E, Michel B Comparative and evolutionary analysis of the bacterial homologous recombination systems. PLoS Genet. 2005 Aug;1(2):e15. Epub 2005 Aug 26. PMID 16132081
[ 2 ]Ivancic-Bace I, Salaj-Smic E, Brcic-Kostic K Effects of recJ, recQ, and recFOR mutations on recombination in nuclease-deficient recB recD double mutants of Escherichia coli. J Bacteriol. 2005 Feb;187(4):1350-6. PMID 15687199
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| Gene Ontology Term | GO:0000724: double-strand break repair via homologous recombination (biological_process)
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| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|
| RecF | RecF | YES | TIGR00611 (HMM): DNA replication and repair protein RecF | GO:0000724: double-strand break repair via homologous recombination
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| exonuclease RecJ | RecJ | YES | TIGR00644 (HMM): single-stranded-DNA-specific exonuclease RecJ | GO:0000724: double-strand break repair via homologous recombination
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| RecN | RecN | NO | TIGR00634 (HMM): DNA repair protein RecN | GO:0000724: double-strand break repair via homologous recombination
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| RecO | RecO | YES | TIGR00613 (HMM): DNA repair protein RecO | GO:0000724: double-strand break repair via homologous recombination
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| helicase RecQ | RecQ | NO | TIGR01389 (HMM): ATP-dependent DNA helicase RecQ | GO:0000724: double-strand break repair via homologous recombination
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| RecR | RecR | YES | TIGR00615 (HMM): recombination protein RecR | GO:0000724: double-strand break repair via homologous recombination
|
