Genome Property Definition Page

NamerecFOR recombination pathway
DescriptionRecFOR is a system for homologous recombination, a nearly universal housekeeping process especially important for repair. RecFOR acts independently from the RecBCD system, or the AddAB system that replaces RecBCD in certain lineages, and the presence of RecFOR is actually positively correlated with the presence of RecBCD/AddAB, so these two presynaptic systems that act in loading RecA may be regarded as complementary. RecFOR especially repairs single-stranded gaps while RecBCD/AddAB repairs double-stranded DNA ends, although roles for RecFOR in double stranded break repair are shown in discussion of RecN and RecQ function and of recBCD mutants. RecFOR systems often are assisted in an early step by the exonuclease RecJ. Following strand exchange by RecA, Holliday junction resolution may be done by RuvABC or RecG. The action of the RecFOR pathway involves formation of RecOR complexes, and RecFR complexes, but no complex of all three. Of the three genes, either RecO or RecF may be missing while the other two components are present, but RecR must be present in genomes with any part of this system.
JCVI RoleDNA replication, recombination, and repair
Parent PropertyGenProp0115: DNA repair
Literature References
[ 1 ]Rocha EP, Cornet E, Michel B  Comparative and evolutionary analysis of the bacterial homologous recombination systems.  PLoS Genet. 2005 Aug;1(2):e15. Epub 2005 Aug 26.  PMID 16132081
[ 2 ]Ivancic-Bace I, Salaj-Smic E, Brcic-Kostic K  Effects of recJ, recQ, and recFOR mutations on recombination in nuclease-deficient recB recD double mutants of Escherichia coli.  J Bacteriol. 2005 Feb;187(4):1350-6.  PMID 15687199
Gene Ontology TermGO:0000724: double-strand break repair via homologous recombination (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
RecFRecFYESTIGR00611 (HMM): DNA replication and repair protein RecFGO:0000724: double-strand break repair via homologous recombination
exonuclease RecJRecJYESTIGR00644 (HMM): single-stranded-DNA-specific exonuclease RecJGO:0000724: double-strand break repair via homologous recombination
RecNRecNNOTIGR00634 (HMM): DNA repair protein RecNGO:0000724: double-strand break repair via homologous recombination
RecORecOYESTIGR00613 (HMM): DNA repair protein RecOGO:0000724: double-strand break repair via homologous recombination
helicase RecQRecQNOTIGR01389 (HMM): ATP-dependent DNA helicase RecQGO:0000724: double-strand break repair via homologous recombination
RecRRecRYESTIGR00615 (HMM): recombination protein RecRGO:0000724: double-strand break repair via homologous recombination

Parent Properties
GenProp0115DNA repair

Sibling Properties
GenProp0114nucleotide excision repair
GenProp0198ruvABC Holliday junction complex
GenProp0215SOS response
GenProp0216recBCD pathway
GenProp0224nucleotide excision repair, alternative pathway
GenProp0225mismatch repair
GenProp0227excision repair
GenProp0228direct repair
GenProp0492nonhomologous end-joining, bacterial type
GenProp0493addAB pathway
GenProp0767very short patch repair
GenProp10998-oxoguanine DNA repair