Genome Property Definition Page
| Accession | GenProp0211 |
| Name | tmRNA trans-translation system |
| Type | SYSTEM |
| Description | Defective mRNA can lead to a stalled ribosome with no stop codon to release the mRNA and nascent polypeptide. A structural RNA called tmRNA (or SsrA), charged like a tRNA with an Ala, can restart stranslation. The tmRNA, while resembling a tRNA, contains a stretch that acts as mRNA with a short coding region and stop codon. The coding region encodes a 10-amino acid tag that marks the nascent protein, once released, for rapid degradation. Small protein B (SmpB) is required for tmRNA function and has no other known function. |
| JCVI Role | Other |
| Parent Property | GenProp0197: protein biosynthesis GenProp0301: protein degradation GenProp0462: response to stress |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| tmRNA-binding protein SmpB | SmpB | YES | TIGR00086 (HMM): SsrA-binding protein | |
| SspB adaptor to clpXP | sspB | NO | PF04386 (HMM): stringent starvation protein B | |
| tmRNA structural RNA | tmRNA | YES | tmRNA (RNA) |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0197 | protein biosynthesis |
| GenProp0301 | protein degradation |
| GenProp0462 | response to stress |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0016 | selenocysteine system |
| GenProp0312 | pyrrolysine |
| GenProp0132 | transcription termination - antitermination Nus factors |
| GenProp0148 | release factor 2 programmed frameshift |
| GenProp0174 | ribosome, bacterial, large subunit |
| GenProp0175 | ribosome, bacterial, small subunit |
| GenProp0188 | GatABC aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase complex |
| GenProp0189 | tRNA-Gln direct aminoacylation |
| GenProp0258 | tRNA aminoacylation |
| GenProp0259 | tRNA-Asn direct aminoacylation |
| GenProp0304 | cysteine biosynthesis, tRNA-dependent |
| GenProp0634 | Sigma-54 (RpoN) systems |
| GenProp0692 | selenouridine-containing tRNA |
| GenProp0704 | tRNA U34 carboxymethylaminomethyl modification |
| GenProp0740 | translation initiation, bacterial |
| GenProp0741 | translation elongation, bacterial |
| GenProp0746 | translation termination, bacterial |
| GenProp0812 | rho-dependent termination |
| GenProp0251 | clpXP degradation machine |
| GenProp0684 | FtsH/HflKC protease complex |
| GenProp0833 | proteasome-targeting modification by pupylation |
| GenProp0834 | proteasome, bacterial |
| GenProp0835 | ATP-dependent protease HslVU |
| GenProp0482 | 6S RNA (eubacterial RNA polymerase regulator) |
| GenProp0648 | phage shock protein regulon |