Genome Property Definition Page
Accession | GenProp0833 | |
Name | proteasome-targeting modification by pupylation | |
Type | SYSTEM | |
Description | Pupylation is the process by which the small protein Pup is conjugated to proteins through its C-terminus to a lysine epsilon-amino group of the target. This modification, analogous to ubiquitination in eukaryotes, targets proteins for degradation by archaeal-type proteasomes in Mycobacterium tuberculosis and related Actinobacteria. | |
JCVI Role | Degradation of proteins, peptides, and glycopeptides | |
Parent Property | GenProp0301: protein degradation | |
Literature References |
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Gene Ontology Term | GO:0019941: modification-dependent protein catabolic process (biological_process) |
Components
Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
---|---|---|---|---|
20S proteasome | PROSOME | YES | GenProp0834 (GENPROP): proteasome, bacterial | GO:0019941: modification-dependent protein catabolic process |
ubiquitin-like protein Pup | pup | YES | TIGR03687 (HMM): ubiquitin-like protein Pup | GO:0019941: modification-dependent protein catabolic process |
AAA family ATPase, pupylation-associated | pup_AAA | YES | TIGR03689 (HMM): proteasome ATPase | GO:0019941: modification-dependent protein catabolic process |
Pup ligase | pup_lig | YES | TIGR03686 (HMM): Pup--protein ligase TIGR03688 (HMM): proteasome accessory factor PafA2 | GO:0019941: modification-dependent protein catabolic process GO:0019941: modification-dependent protein catabolic process |
Parent Properties
Accession | Name |
---|---|
GenProp0301 | protein degradation |
Sibling Properties
Accession | Name |
---|---|
GenProp0211 | tmRNA trans-translation system |
GenProp0251 | clpXP degradation machine |
GenProp0684 | FtsH/HflKC protease complex |
GenProp0834 | proteasome, bacterial |
GenProp0835 | ATP-dependent protease HslVU |