Genome Property Definition Page
| Accession | GenProp0188 |
| Name | GatABC aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase complex |
| Type | PATHWAY |
| Description | The GatABC heterotrimer acts as an alternative to direct aminoacylation of tRNA(Gln), tRNA(Asn), or both with its respective amino acid. Rather, the tRNA may be misacylated with Glu in the place of Gln, or Asp in the place of Asn. The phylogenetic ranges over which GatABC orthologs act on Glu-tRNA(Gln), Asp-tRNA(Asn), or both are not fully worked out. It is both in Chlamydia, the Thermus-Deinococcus lineage, and Acidithiobacillus ferrooxidans. In the Archaea, GatDE act on Glu-tRNA(Gln) while GatABC act on Asp-tRNA(Asn). In Lactobacillus and possibly all Firmicutes, GatABC acts on Glu-tRNA(Gln) only. Note that the amidotransferase reaction is a mechanism not only to charge a tRNA with Asn or Gln, but to complete the synthesis of that amino acid. |
| JCVI Role | tRNA aminoacylation |
| Parent Property | GenProp0197: protein biosynthesis GenProp0258: tRNA aminoacylation |
| Web References | MetaCyc Pathway: Glu-tRNA(Gln) amidotransferase |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| glutamyl-tRNA(Gln) amidotransferase, A subunit | gatA | YES | TIGR00132 (HMM): aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, A subunit | |
| glutamyl-tRNA(Gln) amidotransferase, B subunit | gatB | YES | TIGR00133 (HMM): aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit PF01162 (HMM): | |
| glutamyl-tRNA(Gln) amidotransferase, C subunit | gatC | YES | TIGR00135 (HMM): aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit PF02686 (HMM): glutamyl-tRNA(Gln) amidotransferase, C subunit |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0197 | protein biosynthesis |
| GenProp0258 | tRNA aminoacylation |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0016 | selenocysteine system |
| GenProp0312 | pyrrolysine |
| GenProp0132 | transcription termination - antitermination Nus factors |
| GenProp0148 | release factor 2 programmed frameshift |
| GenProp0174 | ribosome, bacterial, large subunit |
| GenProp0175 | ribosome, bacterial, small subunit |
| GenProp0189 | tRNA-Gln direct aminoacylation |
| GenProp0211 | tmRNA trans-translation system |
| GenProp0258 | tRNA aminoacylation |
| GenProp0259 | tRNA-Asn direct aminoacylation |
| GenProp0304 | cysteine biosynthesis, tRNA-dependent |
| GenProp0634 | Sigma-54 (RpoN) systems |
| GenProp0692 | selenouridine-containing tRNA |
| GenProp0704 | tRNA U34 carboxymethylaminomethyl modification |
| GenProp0740 | translation initiation, bacterial |
| GenProp0741 | translation elongation, bacterial |
| GenProp0746 | translation termination, bacterial |
| GenProp0812 | rho-dependent termination |